Advances in Alzheimer’s Disease: From Metabolic Dysregulation to Molecular Pathophysiology and Therapeutics

Dear Colleagues,

Alzheimer’s disease (AD) is increasingly understood as a disorder at the crossroads of metabolism, inflammation, and neurodegeneration. This Special Issue welcomes cutting-edge contributions that illuminate how metabolic dysregulation, including neuroenergetic failure, brain insulin resistance, adipokine signaling, mitochondrial/redox imbalance, and peripheral–central crosstalk, drives the molecular pathophysiology of AD and reveals actionable therapeutic opportunities.

We invite original research, short communications, systematic reviews/meta-analyses, and perspectives spanning molecular mechanisms and multi-omics (genomics, epigenomics, proteomics, metabolomics, lipidomics); biomarkers and imaging (fluid, neuroimaging, digital); neuroimmune interfaces (microglia/astroglia, cytokine networks), vascular–metabolic pathways, and gut–brain or endocrine axes; sex differences and life-course factors; and translational pipelines linking targets to interventions. Therapeutic domains include small molecules, biologics, gene and cell strategies, nutraceuticals, lifestyle/dietary modulators, and data-driven approaches (AI/ML for target discovery, patient stratification, and treatment response).

We particularly encourage studies that (i) connect peripheral metabolic states to central mechanisms; (ii) integrate multi-scale data to uncover causal pathways; (iii) propose or validate biomarkers aligned with clinical endpoints; and (iv) demonstrate mechanistic engagement of targets. Methodology papers that enhance reproducibility, transparency, and open science (e.g., standardized pipelines, sharable code/datasets, and reporting checklists) are also welcome.

Our goal is to assemble a forward-looking collection that maps the continuum from metabolic dysregulation to molecular insight to therapeutic translation, accelerating progress toward meaningful prevention and treatment in AD. Join us in charting the next wave of discovery and innovation.

Dr. Pedro Cisternas
Guest Editor

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