Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 December 2025 | Viewed by 11
Special Issue Editor
Interests: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology
Special Issue Information
Dear Colleagues,
Skin cancers—from actinic‑keratosis-derived squamous cell carcinoma to aggressive metastatic melanoma—are the most common human malignancies and an escalating global burden. Although breakthroughs in genomics, imaging, and immuno‑oncology have reshaped our understanding of cutaneous tumorigenesis, many patients still face delayed diagnoses, therapeutic resistance, and treatment‑limiting toxicities. Deeper insight into disease mechanisms and genuinely innovative interventions are urgently required.
This Special Issue, “Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies” invites original research papers, short communications, and in‑depth reviews that illuminate the biology of skin cancer and translate discovery into improved care. Topics of interest include (i) genomic, epigenomic, and metabolic drivers of malignant transformation; (ii) tumour–stromal–immune crosstalk, microenvironmental dynamics, and the cutaneous microbiome; (iii) emerging biomarkers, liquid biopsies, and advanced imaging for early detection, prognosis, and real‑time therapeutic monitoring; (iv) AI‑assisted predictive modelling and drug discovery pipelines; (v) next‑generation treatments—signal pathway inhibitors, immune checkpoint modulators, adoptive cell therapy, oncolytic viruses, CRISPR‑based platforms, vaccines, photodynamic/photothermal approaches, and nanomedicine‑enabled combinations; (vi) mechanisms of resistance and toxicity mitigation; and (vii) population studies, real‑world evidence, and survivorship quality‑of‑life assessments.
We particularly encourage submissions that bridge fundamental science and clinical practice, present first‑in‑class therapeutic concepts, or showcase interdisciplinary collaborations. By assembling diverse perspectives, this Special Issue seeks to provide a comprehensive snapshot of current progress and to accelerate precision prevention and durable control of skin cancer.
We look forward to receiving your valuable contributions and advancing the fight against skin cancer together.
Dr. Piotr Sobolewski
Guest Editor
Manuscript Submission Information
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Keywords
- skin cancer
- melanoma
- keratinocyte carcinoma
- pathophysiology
- biomarkers
- immunotherapy
- targeted therapy
- nanomedicine
- resistance
- precision oncology
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