Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 August 2026
Special Issue Editor
Interests: Alzheimer's disease; cerebral amyloid angiopathy; blood–brain barrier; neuroinflammation; amyloid-β
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) and related dementias (ADRD) pose an urgent global challenge, caused by complex molecular, vascular, and immunological changes that ultimately result in neuronal damage and cognitive decline. AD is a progressive neurodegenerative disorder and the most common form of dementia, characterized by the buildup of extracellular amyloid-β plaques and intracellular hyperphosphorylated tau tangles. It is also linked to vascular dysfunction and chronic neuroinflammation. Despite decades of extensive research, there are no effective treatments that modify the disease itself. All current treatments are only symptomatic or have limited effects, and they can cause serious side effects. This underscores the urgent need to turn growing mechanistic insights into new therapies.
This Special Issue emphasizes the integration of fundamental pathogenetic mechanisms with innovative therapeutics in AD and ADRD. It focuses on emerging research into the molecular and cellular foundations of these conditions, including aberrant signaling pathways, genetic and epigenetic factors, and protein post-translational modifications. These insights facilitate the development of potential interventions. Particular attention is paid to the diverse neurobiological mechanisms that instigate and advance ADRD, such as, but not limited to, blood–brain barrier (BBB) dysfunction, neuroinflammation, autophagy, mitochondrial impairment, disrupted metabolism, and various molecular and cellular alterations. Collectively, these mechanisms underpin the identification of therapeutic targets. Innovative therapeutic strategies aim to counteract these processes by modulating cell–cell communication, key molecular pathways, enzymatic regulators, and the dynamic properties of membrane lipids and proteins, thereby providing new opportunities to decelerate or alter disease progression.
By gathering diverse original research articles and comprehensive reviews, this Special Issue aims to foster interdisciplinary exchange and accelerate the development of effective therapies for AD and related dementias.
This Special Issue is supervised by Dr. Amal Kaddoumi and assisted by Dr. Amer Al Khalifa and Dr. Nour Al-Ghraiybah. We warmly welcome the submission of short communications, original research articles, and review articles.
Prof. Dr. Amal Kaddoumi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- Alzheimer's disease
- cerebral amyloid angiopathy
- blood–brain barrier
- cerebrovascular dysfunction
- neuroinflammation
- therapeutic development
- translational research
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