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The Role of Lipids in Health and Diseases: 2nd Volume

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 494

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue “The Role of Lipids in Health and Diseases”.

Lipids are vital components of cell membranes and serve as crucial energy sources. Beyond these foundational roles, they are integral to numerous physiological and pathophysiological processes. Lipids act as signaling molecules in inflammation and immune responses, and they are involved in key cellular functions such as division, growth, migration, and apoptosis. Our understanding of how different lipid types influence health and disease is rapidly expanding. This Special Issue of IJMS will showcase the latest research on lipid functions in both health and disease, with a focus on the molecular mechanisms underlying their effects. We welcome articles that explore the physiological and pathophysiological roles of lipids in conditions such as cardiovascular disease, neurological disease, metabolic disease, cancer, aging, inflammation, immunity, etc. We invite submissions of both original research and review articles.

Dr. Yutang Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • lipids
  • triglycerides
  • phospholipids
  • cholesterol
  • sphingolipids
  • steroids
  • fatty acids
  • lipid metabolism

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Published Papers (1 paper)

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Review

24 pages, 3396 KB  
Review
Non-Fasting Glucose Measures and Their Clinical Significance in Diabetes Diagnosis and Cardiovascular and Cancer Risk Prediction: A Narrative Review
by Yutang Wang, David Song, Tongzhi Wu and Eman M. Othman
Int. J. Mol. Sci. 2026, 27(11), 4734; https://doi.org/10.3390/ijms27114734 - 25 May 2026
Viewed by 89
Abstract
Several lipid-management guidelines now favor non-fasting lipid measurements for cardiovascular risk assessment. In parallel, this review evaluated the potential clinical utility of non-fasting glucose measures, which may better reflect real-world glycemic responses, capture postprandial dysregulation not detected by fasting glucose, and offer greater [...] Read more.
Several lipid-management guidelines now favor non-fasting lipid measurements for cardiovascular risk assessment. In parallel, this review evaluated the potential clinical utility of non-fasting glucose measures, which may better reflect real-world glycemic responses, capture postprandial dysregulation not detected by fasting glucose, and offer greater practicality in routine clinical settings. Postprandial plasma glucose measured 4–7.9 h after a meal (PPG4–7.9h) shows relative stability within this window and appears to be a promising marker for diagnosing diabetes and predicting mortality from cardiovascular disease (CVD) and cancer. Similarly, 2 h plasma glucose during an oral glucose tolerance test performed 4–7.9 h after a meal (2 h PGOGTT4–7.9h) demonstrates diagnostic and prognostic value, particularly for diabetes and cardiovascular mortality. Notably, the diagnostic and predictive performance of these non-fasting measures is not inferior to that of traditional fasting glucose assessments. Mechanistically, postprandial hyperglycemia may contribute to CVD through increased oxidative stress and inflammation, endothelial dysfunction, and promotion of atherogenesis and thrombogenesis. It may also increase cancer risk via oxidative stress, inflammation, and insulin-mediated cellular proliferation. In addition, it may enhance lipogenesis to form membrane lipids supporting tumor growth. Further research is required to establish the clinical applicability, optimal thresholds, and generalizability of these non-fasting glucose measures. Full article
(This article belongs to the Special Issue The Role of Lipids in Health and Diseases: 2nd Volume)
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