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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Informatics and AI in Cancer Research

edited by

Nabil Adam

and

Robert Wieder

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2224 | Submission Open

Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data

(This special issue belongs to the Section Molecular Informatics)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases

edited by

Eiko Nakamaru-Ogiso

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2171 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Machine Learning in Disease Diagnosis and Treatment: 2nd Edition

edited by

Makrina Karaglani

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2106 | Submission Open

Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Autoimmune Diseases: The Molecular Basis and New Therapies

edited by

Adawi Mohammad

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2014 | Submission Open

Keywords: autoimmunity; molecular mechanisms; biologics; immunotherapy; precision medicine

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapies of Pancreatic Cancer: 3rd Edition

edited by

Donatella Delle Cave

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2004 | Submission Open

Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Crosstalk in Stress-Induced Psychopathology

edited by Ilaria Demori and

Natalia V. Gulyaeva

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1962 | Submission Open

Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota–gut–brain axis; Blood–brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Angiogenesis: From Molecular Insights to Therapeutic Strategies

edited by

Emanuela Pessolano

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1919 | Submission Open

Keywords: angiogenesis; molecular signaling; endothelial cells; tumor microenvironment; pro-angiogenic factors; anti-angiogenic therapy; vascular remodeling; hypoxia; VEGF pathway; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cancer Epigenetics for Precision Medicine

edited by

Alessandro Lavoro

and

Saverio Candido

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1898 | Submission Open

Keywords: cancer epigenetics; DNA methylation; precision medicine; cancer biomarker; therapeutic target; epidrugs

(This special issue belongs to the Section Molecular Oncology)

Breast Cancer and Hormone Receptors: Molecular Insights

edited by

Alkistis Papatheodoridi

and

Antonella Muscella

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1887 | Submission Open

Keywords: hormone receptor-positive breast cancer; estrogen receptor (ER); progesterone receptor (PR); endocrine therapy resistance; breast cancer genomics; molecular biomarkers; transcriptomic profiling; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy (Second Edition)

edited by

Karolina Orywal

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1880 | Submission Open

Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers

(This special issue belongs to the Section Molecular Oncology)

The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches

edited by

Agnes Chan

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1878 | Submission Open

Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Molecular Aspects of Cancer Stem Cell Biology and Their Therapeutic Implications

edited by

Tanja Matijevic Glavan

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1863 | Submission Open

Keywords: cancer stem cells; chemotherapy; radiotherapy; transcription factors; stemness properties; chemoresistance; radioresistance

(This special issue belongs to the Section Molecular Oncology)

Drug Treatment for Bacterial Infections: 2nd Edition

edited by Janusz Madaj

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1836 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Stem Cells for Biomedical Applications

edited by

Sorina Dinescu

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1803 | Submission Open

Keywords: stem cells biology; stem cells differentiation; stem cell-based regenerative therapies; stem cells exosomes; personalized medicine; stem cell-based 3D models

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer

edited by

Yutang Wang

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1783 | Submission Open

Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management

edited by

Abdul Kader Jailani Amirudeen

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1780 | Submission Open

Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC

(This special issue belongs to the Section Molecular Plant Sciences)

Current Advances and Perspectives in Microbial Genetics and Genomics—2nd Edition

edited by

Marcello Tagliavia

and Lucila Saavedra

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1748 | Submission Open

Keywords: microbial genetics; genomics and metagenomics; yeasts; gene regulation; microbe–host interactions; adaptation and resistance mechanisms; microbial metabolism

(This special issue belongs to the Section Molecular Microbiology)

Advanced Research on Antimicrobial Nanomaterials

edited by

Nenad Filipovic

and

Magdalena Stevanović

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1729 | Submission Open

Keywords: antimicrobial nanomaterials; metal/metal-oxide nanoparticles; stimuli-responsive platforms; photothermal/photodynamic mechanisms; biofilm inhibition

(This special issue belongs to the Section Materials Science)

Molecular Insights into Ophthalmic Diseases

edited by

Alicja Forma

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1720 | Submission Open

Keywords: environmental hazards; ophthalmic diseases; molecular mechanisms; risk factors; disease prevention; oxidative stress; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Biochemical Advances in Kidney Diseases and Genetics

edited by

Silvio R. De Luka

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1712 | Submission Open

Keywords: pathophysiology; molecular mechanisms; biomarkers; in silico data analysis; image analysis; animal models

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research Advances in Plant Interactions with Bacteria and Fungi: From Molecular to Ecological Perspectives

edited by

Jessie Fernandez

submission deadline 25 Dec 2026 | 3 articles | Viewed by 1690 | Submission Open

Keywords: plant-microbe interactions; plant-bacteria interactions; plant-fungi interactions; biocontrol; beneficial microbes; endophytes; microbiome; plant growth-promoting microbes; synthetic microbial communities

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Omics Insights into Stress Responses and Adaptation in Fish

edited by

Zongbin Cui

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1651 | Submission Open

Keywords: fish stress adaptation; environmental stressors; omics integration; molecular mechanisms; functional genomics; epigenetic regulation; systems biology; stress resilience

(This special issue belongs to the Section Molecular Biology)

Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action

edited by

Tianfang Wang

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1642 | Submission Open

Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure–function relationships

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Myocardial Disease

edited by

Maicon Landim-Vieira

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1641 | Submission Open

Keywords: cardiac muscle; calcium; sarcomere; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; mitochondria; calmodulin

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Omics Approaches in Toxicology and Precision Pharmacology

edited by

Mirjana M. Djukić

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1593 | Submission Open

Keywords: toxicology; precision pharmacology; omics technologies; proteomics; mode of action (MoA); mechanism of activity; biomarkers; prediction and modeling

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Reproduction and Reproductive Diseases

edited by

Sung Tae Kim

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1504 | Submission Open

Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering

edited by

Elisa Boanini

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1388 | Submission Open

Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility

(This special issue belongs to the Section Materials Science)

Anti-Cancer Effects of Natural Products: 2nd Edition

edited by

Moon Nyeo Park

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1359 | Submission Open

Keywords: cancer; natural products; herbal medicine; anticancer therapies; metastasis; recurrence; resistance mechanism; novel biomarker

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Electrochemical Detection Research: A Molecular Insight

edited by

Gastón Pierini

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1359 | Submission Open

Keywords: electrochemical sensors; phenolic compounds; theoretical study; experimental study; nanostructured electrodes

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1348 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1319 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Vitamin B6 in Metabolism and Genome Stability

edited by

Fiammetta Verni

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1319 | Submission Open

Keywords: vitamin B6; PLP; DNA damage; metabolism

(This special issue belongs to the Section Molecular Biology)

Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1302 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Metabolism of Alzheimer’s Disease

edited by

Rebecca Piccarducci

and Maria Letizia Trincavelli

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1294 | Submission Open

Keywords: Alzheimer’s disease; brain metabolism; insulin resistance; lipid metabolism; APOE ε4; metabolic targets; insulin-sensitizing drugs; lifestyle and metabolic interventions

(This special issue belongs to the Section Molecular Neurobiology)

Plant Extracts and Their Biological Activities: In Vitro and In Vivo

edited by

Ângelo Luís

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1274 | Submission Open

Keywords: plant extracts; bioactive compounds; molecular mechanisms; in vitro and in vivo studies; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Comparative Reproductive Physiology

edited by

Heriberto Rodriguez-Martinez

and

Manuel Álvarez-Rodríguez

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1248 | Submission Open

Keywords: andrology; sperm; oocyte; gamete interactions; reproductive morphology; reproductive endocrinology; omics; epigenetics; pregnancy; all animal species

(This special issue belongs to the Section Molecular Biology)

Identification of Predictive Molecular Markers for Cancer Progression, Response to Therapy, and Disease Outcome

edited by

Shadma Fatima

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1228 | Submission Open

Keywords: predictive biomarkers; cancer progression; therapy response; molecular signatures; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Characterization and Biological Function of Marine Biopolymers

edited by

Zahira Belattmania

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1220 | Submission Open

Keywords: marine-based biopolymers; sustainable extractions; polymer characterization; biological functions; marine resources

(This special issue belongs to the Section Materials Science)

Exploring the Functional Activity of Natural Products

edited by

Antonio Speciale

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1214 | Submission Open

Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions

edited by

Adelina-Gabriela Niculescu

and

Ariana Hudita

submission deadline 25 Dec 2026 | Viewed by 1178 | Submission Open

Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease

edited by

Érika Bevilaqua Rangel

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1135 | Submission Open

Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Food Components in Human Health

edited by

Kamila Rachwał

and Klaudia Gustaw

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1100 | Submission Open

Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Regulatory Mechanisms of the Tumor Microenvironment in Human Diseases

edited by

Cornelia Amalinei

and

Adriana Grigoraș

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1072 | Submission Open

Keywords: tumor microenvironment; cytokines; exosomes; non-tumor cells; tumor-associated immune cells; cancer prognosis; cancer diagnosis; oncotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration

edited by Hyun Jin Shin

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1061 | Submission Open

Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Recent Research on Natural Compounds: From Biosynthesis to Application

edited by

Nitin Mantri

submission deadline 25 Dec 2026 | Viewed by 1042 | Submission Open

Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery

(This special issue belongs to the Section Biochemistry)

Emerging Strategies in Tuberculosis Drug Discovery

edited by

Parvesh Singh

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1036 | Submission Open

Keywords: anti-tuberculosis agents; MDR-TB; XDR-TB; drug repurposing; hybrid drugs; high-throughput screening; structure-based drug design; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Advanced in In Silico Methods for Rational Drug Design and Predictive Toxicology

edited by

Gnanendra Shanmugam

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: rational drug design; predictive toxicology; molecular modeling; AI in drug discovery; QSAR; molecular docking; ADMET

(This special issue belongs to the Section Molecular Informatics)

Epilepsy: Molecular Neuropharmacology, Calcium Signalling, Neuroinflammation, and Drug Discovery

edited by Maria F. Cano-Abad

submission deadline 25 Dec 2026 | 1 articles | Viewed by 986 | Submission Open

Keywords: epilepsy receptor pharmacology; neurotransmitter receptor modulation; calcium signaling and homeostasis; therapeutic targets in epilepsy; GABAergic and glutamatergic systems

(This special issue belongs to the Section Molecular Neurobiology)

Unravelling Molecular Pathways in Ocular Disease and Degeneration

edited by

Zala Lužnik Marzidovšek

submission deadline 25 Dec 2026 | 1 articles | Viewed by 937 | Submission Open

Keywords: molecular mechanisms; ocular disease; biomarkers; therapeutic targets; regenerative; gene therapies; corneal degeneration; retinal degeneration; optic nerve pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioinformatics of Genome Regulation and Structure–2026

edited by