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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Diagnostics and Therapeutic Targets in Bladder Cancer (Second Edition)
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 5139 | Submission Open
Keywords: non-muscle invasive bladder cancer; muscle-invasive bladder cancer; metastatic bladder cancer; diagnostic biomarkers; therapeutic targets; early detection; progression biomarkers; liquid biopsy; genomic profiling; proteomics; metabolomics; imaging biomarkers; multi-omics; targeted therapy; immunotherapy; antibody–drug conjugates; DNA damage response; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Latest Development of Molecular Research in Animal Nutrition submission deadline 20 Sep 2026 | 3 articles | Viewed by 5007 | Submission Open
Keywords: animal nutrition; molecular biology; microbiome; feed efficiency; sustainable aquaculture; proteomics; metabolomics; molecular mechanisms; metabolic regulation; disease resistance
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia
edited by Fabrizio Barbetti
submission deadline 20 Sep 2026 | 3 articles | Viewed by 4957 | Submission Open
Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Current Advances in Immuno-Oncology
edited by Gratiela Grădișteanu Pircălabioru
submission deadline 20 Sep 2026 | 3 articles | Viewed by 4865 | Submission Open
Keywords: immuno-oncology; tumor microenvironment; immune checkpoint inhibitors; CAR-T cells; adoptive cell therapy; cancer vaccines; oncolytic viruses; tumor immune evasion; immunometabolism; biomarkers; tumor immunology; microbiome and cancer
(This special issue belongs to the Section Molecular Oncology)
Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment, 2nd Edition
edited by and Dominika Marta Stygar
submission deadline 20 Sep 2026 | 3 articles | Viewed by 4863 | Submission Open
Keywords: viral infections; virus mutations; molecular diagnostic methods; antiviral drugs/preparations; viral diseases; physiological mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Mechanism Research on Listeria monocytogenes and Its Control submission deadline 20 Sep 2026 | 1 articles | Viewed by 4818 | Submission Open
Keywords: Listeria monocytogenes; virulence; biofilm; pathogenicity; control; prevention; food safety
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanism of Immune Response
edited by Marisa Mariel Fernández
submission deadline 20 Sep 2026 | 5 articles | Viewed by 4773 | Submission Open
Keywords: training of the innate immune response; antigen recognition; cell migration; autoimmune processes; cell differentiation; tolerance; molecular responses of epithelial cells to foreign stimuli; alterations in immune checkpoints; modulation of immune responses; mechanisms of hypersensitivity
(This special issue belongs to the Section Molecular Immunology)
Medicinal Mechanisms of Biologically Active Compounds in Cancer submission deadline 20 Sep 2026 | 2 articles | Viewed by 4688 | Submission Open
Keywords: biologically active compounds; cancer treatment; apoptosis; tumor growth; natural products; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition submission deadline 20 Sep 2026 | 3 articles | Viewed by 4435 | Submission Open
Keywords: cardiovascular disease; myocardial infarction; stroke; transient ischemic attack; hypertension; diabetes mellitus; atherosclerosis; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 4423 | Submission Open
Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy
(This special issue belongs to the Section Molecular Immunology)
The Role of Trace Elements in Nutrition and Health, 2nd Edition
edited by Jie Feng
submission deadline 20 Sep 2026 | 4 articles | Viewed by 4312 | Submission Open
Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience
edited by Matteo Di Segni and Rossella Ventura
submission deadline 20 Sep 2026 | 2 articles | Viewed by 4264 | Submission Open
Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Immune Response to Virus Infection and Vaccines
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 4213 | Submission Open
Keywords: immunogenicity; emerging pathogen vaccination; molecular and cellular determinants of vaccine responses in immunocompromised individuals; predictive markers of immune response; laboratory methods to dissect immune responses to infections and vaccinations
(This special issue belongs to the Section Molecular Immunology)
Plant Metabolism and Natural Product Biosynthesis
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 4135 | Submission Open
Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Ion Transporters and Channels
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 4032 | Submission Open
Keywords: ion transporter; ion channel; proton; interstitial fluid pH; Na+ channels; K+ channels; Cl− channels; ENaC; CALHM
(This special issue belongs to the Section Biochemistry)
Damage to Plants and Microorganisms Caused by Heavy Metal Toxicity
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 4002 | Submission Open
Keywords: metal; oxidative stress; stress response; molecular function; gene regulation; metabolic regulation; signaling pathway
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Phenolics and Polyphenols 2025
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3996 | Submission Open
Keywords: phenolic metabolism; biological activities; stability to food processing; elicitation; methods of analysis; dietary supplements; nutraceutical ingredients; non-thermal processing; extraction and purification
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Quantum Chemical Approaches for Investigating Reaction Mechanisms in Organic Chemistry
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 3924 | Submission Open
Keywords: organic chemistry; biochemistry; density functional theory; coupled cluster theory; free radicals; reaction mechanisms; transition states
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Pathophysiology and Molecular Mechanisms of Cardiovascular, Cardiometabolic, and Cardiorenal Diseases
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3912 | Submission Open
Keywords: heart failure; cardiorenal syndrome; oxidative stress; inflammation; endothelial dysfunction; fibrosis and remodeling; mitochondrial function and energy metabolism; insulin resistance; epigenetics and microRNAs; biomarkers and precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Towards Complex Molecular Cancer Therapies
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3833 | Submission Open
Keywords: precision medicine; immune system harnessing; targeted therapies; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh
(This special issue belongs to the Section Molecular Oncology)
Drugs—from Chemical Structure to Biological Activity
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3787 | Submission Open
Keywords: hit molecule; lead optimization; drug design; virtual screening; molecule descriptors; structure–activity relationship; pharmacokinetic/ADME profile; in vitro biological activity
(This special issue belongs to the Section Molecular Pharmacology)
Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3622 | Submission Open
Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing
(This special issue belongs to the Section Molecular Oncology)
Molecular Synapse: Diversity, Function and Signaling
edited by Leonora Balaj
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3552 | Submission Open
Keywords: synaptic signaling; synaptic plasticity; brain disorders; synapse diversity; molecular composition of synapse
(This special issue belongs to the Section Molecular Neurobiology)
Applications of Bioinformatics in Human Disease
edited by Maria Rosaria De Filippo
submission deadline 20 Sep 2026 | 3 articles | Viewed by 3546 | Submission Open
Keywords: bioinformatics; omics data; machine learning; biomarker prediction
(This special issue belongs to the Section Molecular Informatics)
The Regulation of Microorganisms on Human Endocrine and Metabolic Systems
edited by Thi Phuong Nam Bui and Valentina Tremaroli
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3388 | Submission Open
Keywords: human gut microbiome; endocrine signaling; metabolism; obesity; type 2 diabetes; cardiometabolic diseases
(This special issue belongs to the Section Molecular Microbiology)
The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments
edited by Angelo Delmonte and Alberto Verlicchi
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3383 | Submission Open
Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies 
(This special issue belongs to the Section Molecular Oncology)
Recent Progress in Biological and Molecular Mechanisms and Targeted Therapies of Leukemia
edited by Anna Sicuranza
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3359 | Submission Open
Keywords: leukemia-targeted therapies; AML; CML; venetoclax combination therapy; tyrosine kinase inhibitors (TKIs); hypomethylating agents; ALL; CLL; CAR-T cell therapy; monoclonal antibodies; immune checkpoint inhibitors; resistance mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plasma-Based Technologies for Food Safety and Health Enhancement
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3341 | Submission Open
Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation
(This special issue belongs to the Section Biochemistry)
Relationship Between Plant Microbiome and Immunity
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3291 | Submission Open
Keywords: microbiome; plant immune system; rhizosphere of plant roots; microbe-associated molecular patterns (MAMPs)
(This special issue belongs to the Section Molecular Plant Sciences)
Contribution of Astrocytes and Microglia for the Development of Neurological Disorders submission deadline 20 Sep 2026 | 2 articles | Viewed by 3256 | Submission Open
Keywords: aging; astrocytes; glial cells; microglia; neurodegenerative diseases; neuron-glia interaction; neuroimmune response; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Oral and Dental Infectious Diseases: Molecular Pathology, Diagnosis and Therapy (2nd Edition) submission deadline 20 Sep 2026 | 2 articles | Viewed by 3178 | Submission Open
Keywords: oral; dental; periodontitis; tooth decay; periodontal diseases; gingivitis; oral microorganism; oral infections; dental infections; dental caries; microbial pathogenicity; porphyromonas gingivalis; antimicrobials; oral biofilm
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources submission deadline 20 Sep 2026 | 3 articles | Viewed by 3123 | Submission Open
Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Differential Role of B Cells in Autoimmune Diseases: From Autoantibodies to Antigen Presentation
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3090 | Submission Open
Keywords: autoantibodies; B cells; antigen presentation; B cell functions; autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Molecular Research and Utilization of Environmental Microbial Resources
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 3072 | Submission Open
Keywords: environmental microbiology; molecular microbial resources; microbial metabolites; microbial diversity; microbial ecology; bioremediation; agricultural microbiology; omics technologies; biofilm formation; microbiome applications
(This special issue belongs to the Section Molecular Microbiology)
Neuromodulatory Effects of Serotonin, 2nd Edition
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3046 | Submission Open
Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM
(This special issue belongs to the Section Molecular Neurobiology)
Kidney Diseases: Molecular Research and Novel Therapies
edited by Niels Olsen Saraiva Camara
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3020 | Submission Open
Keywords: kidney disease; immunology and inflammation; zebrafish models; therapeutic targets; modern-era drivers of renal pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Targets in Alzheimer’s Disease: From Mechanisms to Therapeutic Strategies submission deadline 20 Sep 2026 | 2 articles | Viewed by 3005 | Submission Open
Keywords: amyloid beta; neurodegeneration; neuroinflammation; microglia; mitochondrial dysfucntion; oxidative stress; molecular pathway; biomarkers of AD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Functional Foods: Molecular Insights into Nutrition and Health submission deadline 20 Sep 2026 | 3 articles | Viewed by 2919 | Submission Open
Keywords: functional foods; bioactive compounds; disease prevention; nutritional health; food innovation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights in Antimicrobial Resistance submission deadline 20 Sep 2026 | 1 articles | Viewed by 2908 | Submission Open
Keywords: drug resistance; microorganisms; molecular mechanisms; mobile genetic elements; CRISPR/Cas9; nucleic acid hybriditation; probes; LAMP
(This special issue belongs to the Section Molecular Microbiology)
Biological Barriers: Consciousness and Mental Illness
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2872 | Submission Open
Keywords: cell membranes; transport protein regulation; blood–brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood–saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases
(This special issue belongs to the Section Molecular Biology)
Unraveling the Molecular Landscape of Systemic Lupus Erythematosus
edited by Yoshinori Matsumoto
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2864 | Submission Open
Keywords: systemic lupus erythematosus; autoimmunity; molecular mechanisms; immune regulation; type I interferon; biomarkers; multi-omics; signal transduction; precision medicine; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Nanosensors for Molecular Sensing Applications
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2832 | Submission Open
Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor
(This special issue belongs to the Section Molecular Nanoscience)
Antioxidants: Design, Synthesis, and Mechanism of Actions
edited by Choon Young Lee
submission deadline 20 Sep 2026 | 4 articles | Viewed by 2800 | Submission Open
Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator
(This special issue belongs to the Section Macromolecules)
Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management—2nd Edition submission deadline 20 Sep 2026 | 3 articles | Viewed by 2799 | Submission Open
Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms of Tumor Progression and New Therapeutic Strategies for Urological Cancers, 3rd Edition submission deadline 20 Sep 2026 | 3 articles | Viewed by 2786 | Submission Open
Keywords: prostate cancer; bladder cancer; renal cell carcinoma; upper urinary tract tumors; testicular cancer; predictive and prognostic biomarkers; tumor progression; novel treatment strategies; chemotherapy; immunotherapy; target therapies; drug resistance mechanisms; tumor microenvironment; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Zoonotic Diseases: Current Advances and Perspectives submission deadline 20 Sep 2026 | 2 articles | Viewed by 2742 | Submission Open
Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Prospects in Neurons
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 2660 | Submission Open
Keywords: DNA damage/repair; genetic/epigenetic; 3D genomic; global transcriptome analysis; transgenic animals; neuron polarization/genesis/network; neuro-developmental/psychiatric diseases; brain structures; intelligence/intellectual disability
(This special issue belongs to the Section Molecular Neurobiology)
Spectral Control of Stress Response in Plants
edited by and Zsolt Gulyás
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2600 | Submission Open
Keywords: spectral control; stress response; light spectrum; photoreceptor; reactive oxygen; plant hormone; antioxidant; plant growth and development
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Vitiligo: From Mechanisms to Treatment Innovations
edited by Hyun Jeong Ju
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2543 | Submission Open
Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pain Pathways Rewired: Moving past Peripheral Ion Channel Strategies
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2506 | Submission Open
Keywords: central mechanism of action; central terminal; chronic pain; multichannel block; NaV channel; non-neuronal cell; novel analgesics; pain transduction; subthreshold membrane potential oscillation; TRP channel
(This special issue belongs to the Section Molecular Biology)
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