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Towards Complex Molecular Cancer Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1654

Special Issue Editor


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Guest Editor
Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 814 99 Bratislava, Slovak Republic
Interests: neurobiology; cancer; inflammation; psychoneuroimmunomodulation; supportive cancer care
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Special Issue Information

Dear Colleagues,

Complex cancer management requires a multidisciplinary approach that incorporates various medical specialties, advanced technologies, and supportive care services. This holistic approach aims to address the physical, emotional, and social needs of cancer patients throughout their treatment journey.

Key aspects of complex cancer management include the following:

  • Precision Medicine: Utilizing advanced technologies, such as genomics and proteomics, to tailor treatment plans based on individual patient characteristics.
  • Immunotherapy: Harnessing the body's immune system to fight cancer cells, offering new hope for patients with previously difficult-to-treat cancers.
  • Targeted Therapies: Developing drugs that specifically target cancer cells while minimizing damage to healthy tissues.

By combining these elements, healthcare providers can offer patients more effective and personalized care, ultimately improving outcomes and enhancing their overall well-being.

Dr. Luba Hunáková
Guest Editor

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Keywords

  • precision medicine
  • immune system harnessing
  • targeted therapies
 

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Published Papers (1 paper)

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Research

22 pages, 2262 KiB  
Article
Association of Sympathovagal Imbalance with Increased Inflammation and Impaired Adaptive Immunity in Bladder Cancer Patients
by Iveta Mikolaskova, Milan Zvarik, Kinga Szaboova, Elena Tibenska, Vladimira Durmanova, Magda Suchankova, Boris Kollarik, Patrik Hesko, Patrik Palacka, Maria Bucova and Luba Hunakova
Int. J. Mol. Sci. 2024, 25(23), 12765; https://doi.org/10.3390/ijms252312765 - 27 Nov 2024
Cited by 1 | Viewed by 1320
Abstract
Stress responses can impact bladder cancer (BC) outcomes via immune–inflammatory pathway modulation. This study explores heart rate variability (HRV) associations with serum immune–inflammatory biomarkers, blood count inflammatory markers, and psychosocial self-report measures in patients versus healthy controls. The TREM-1 and TREM-2 expressions on [...] Read more.
Stress responses can impact bladder cancer (BC) outcomes via immune–inflammatory pathway modulation. This study explores heart rate variability (HRV) associations with serum immune–inflammatory biomarkers, blood count inflammatory markers, and psychosocial self-report measures in patients versus healthy controls. The TREM-1 and TREM-2 expressions on peripheral blood monocytes were analysed via flow cytometry; serum inflammatory biomarkers by ELISA; HRV (5-min ECG) pre-tumour resection; blood counts by haematology analyser; and psychosocial factors by validated questionnaires. Patients exhibited altered immune–inflammatory profiles with increased TREM-1/TREM-2, sTREM-1, sTREM-1/sTREM-2 ratio, BDNF, MCP-1, and NLR, and reduced IFN-γ, IL-10, LMR, and PMR. HRV analysis indicated sympathetic dominance (SNS, Stress indices, ACmod) and reduced parasympathetic modulation (PNS index, SDNN, RMSSD, 2UV%, DCmod, SD1). Sympathetic HRV indices correlated positively with sTREM-1, sTREM-1/sTREM-2 ratio, fractalkine, and inflammatory markers (SII, NLR, PLR) and negatively with parasympathetic HRV indices—correlations absent in controls. Only in patients, reduced physical function and social support, and higher anxiety, depression, and fatigue, associated positively with sympathetic HRV indices and inflammatory markers. This study links immune–inflammatory markers, HRV parameters, and psychosocial factors in BC, suggesting that immune and autonomic variations may relate to unfavourable outcomes. Incorporating these assessments could help tailor more personalised treatment strategies for BC patients. Full article
(This article belongs to the Special Issue Towards Complex Molecular Cancer Therapies)
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