Ion Transporters and Channels
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 18
Special Issue Editor
2. Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
3. Research Organization of Science and Technology, Ritsumeikan University, Kusatsu 525-8577, Japan
Interests: diabetes mellitus; cancer; ion environments; interstitial fluid pH; ion transporters; ion channels
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ion transporters and channels play a critical role in the regulation of basic functions in living organisms. It is well-documented that their disruption is associated with a number of diseases, including cardiovascular disorders, metabolic disorders, and disorders of the central and autonomic nervous systems. During the process of cellular energy production, the body produces protons, which are then excreted by proton transporters expressed on the cell membrane. These protons are ultimately excreted from the body via the lungs and the kidneys. The first step in the process is the release of acids from the intracellular space into the interstitial fluid. These acids are then transported to the blood vessels for excretion via the lungs and kidneys. Whilst the importance of interstitial fluid is often overlooked, it is an important site of hormone–receptor interactions. In particular, the pH of interstitial fluid has been shown to have a significant impact on the binding affinity of the insulin receptor. Furthermore, ion transporters and ion channels are also involved in neuronal activity. It is also well known that blood pressure, which is essential for the transport of substances in the body, is regulated via sodium ion transporters and ion channels that regulate fluid volume. This Special Issue aims to share work exploring the molecular mechanisms of ion transporter and ion channel regulation in basic and clinical application research, including at the theoretical level. I warmly welcome your contributions and expertise on this rapidly advancing field.
Prof. Dr. Yoshinori Marunaka
Guest Editor
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Keywords
- ion transporter
- ion channel
- proton
- interstitial fluid pH
- Na+ channels
- K+ channels
- Cl− channels
- ENaC
- CALHM
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