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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on HIV Virus and Infection
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 16035 | Submission Open
Keywords: HIV; viral proteins; immunogenetics; pathogenesis
(This special issue belongs to the Section Molecular Immunology)
Current Research on Bioactives from Natural Products submission deadline 20 Dec 2025 | 5 articles | Viewed by 15859 | Submission Open
Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits
(This special issue belongs to the Section Molecular Biology)
Recombinant Proteins, Protein Folding and Drug Discovery submission deadline 20 Dec 2025 | 7 articles | Viewed by 15850 | Submission Open
Keywords: heterologous hosts for gene expression; recombinant therapeutic proteins; antigens; and antibodies; large scale production of recombinant proteins; recombinant protein bioreactor; downstream processing of recombinant proteins; codon optimization for protein expression; refolding of misfolded recombinant proteins; solubilization of aggregated and inclusion bodies of recombinant proteins; protein target validation for drug discovery and development; protein target expression for drug discovery and development; metabolic engineering of recombinant protein production; regulatory noncoding RNAs to boost the expression of protein; the use of foldases & conformases in recombinant protein expression; delivery of therapeutic proteins; therapeutic protein Vs mRNA therapeutics
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Therapies in Skeletal Muscle Diseases
edited by Valeria Guglielmi
submission deadline 20 Dec 2025 | 4 articles | Viewed by 15706 | Submission Open
Keywords: skeletal muscle; skeletal muscle diseases; pathogenesis; molecular mechanism; muscle degeneration; muscle regeneration; myokines; cell therapy; gene therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 15591 | Submission Open
Keywords: mass spectrometry; quantitative analysis; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Immunity and Inflammation in Cardiovascular Diseases
edited by
submission deadline 20 Dec 2025 | 6 articles | Viewed by 15259 | Submission Open
Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation
(This special issue belongs to the Section Molecular Immunology)
(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems
edited by , Milton Saier and Gabriel Moreno-Hagelsieb
submission deadline 20 Dec 2025 | 3 articles | Viewed by 14754 | Submission Open
Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors
edited by
submission deadline 20 Dec 2025 | 11 articles | Viewed by 14624 | Submission Open
Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design
(This special issue belongs to the Section Molecular Oncology)
Plant Genome Editing
edited by Lei Gao
submission deadline 20 Dec 2025 | 5 articles | Viewed by 14038 | Submission Open
Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database
(This special issue belongs to the Section Molecular Plant Sciences)
Biomarkers and Early Detection Strategies of Ovarian Tumors
edited by Lukasz Szafron
submission deadline 20 Dec 2025 | 7 articles | Viewed by 13970 | Submission Open
Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment
(This special issue belongs to the Section Molecular Oncology)
Breast Cancer: From Pathophysiology to Novel Therapies
edited by Jennifer Sims-Mourtada
submission deadline 20 Dec 2025 | 7 articles | Viewed by 13763 | Submission Open
Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies
(This special issue belongs to the Section Molecular Oncology)
In Honor of Elie Metchnikoff, a Nobel Prize Winner, Who Discovered Macrophages as Phagocyte Cells Involved in the Process of Innate Immunity
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 12982 | Submission Open
Keywords: macrophages; monocytes; phagocytes; fibroblast; cytokines; chronic disease; autoimmune disease; inflammatory disease; immune response; disease treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Primary and Secondary Bladder Disorders in Neurourology and Inflammatory Diseases submission deadline 20 Dec 2025 | 6 articles | Viewed by 12564 | Submission Open
Keywords: bladder ischemia; bladder pain syndrome; interstitial cystitis; irradiation cystitis; ketamine cystitis; microbiota; overactive bladder; underactive bladder; botulinum toxin for bladder disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Natural Products in Drug Discovery submission deadline 20 Dec 2025 | 8 articles | Viewed by 12123 | Submission Open
Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry
(This special issue belongs to the Section Molecular Pharmacology)
RNA Vaccines and Therapeutics: Challenges and Opportunities
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 11278 | Submission Open
Keywords: RNA-based therapy; RNA vaccine; mRNA; circRNA; saRNA; non-coding RNA/sRNA; microRNA/siRNA/antisense RNA; RNA aptamer; ribozyme; RNA editing/genome editing
(This special issue belongs to the Section Molecular Pharmacology)
Phytochemicals of Natural Products: Source, Analysis, and Bioactivities
edited by , Chi-I Chang and Chi-Chien Lin
submission deadline 20 Dec 2025 | 5 articles | Viewed by 11221 | Submission Open
Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Topoisomerase Inhibitors: Future Perspectives and Challenges
edited by and Mark Mitton-Fry
submission deadline 20 Dec 2025 | 3 articles | Viewed by 11110 | Submission Open
Keywords: antibiotic; topoisomerase; inhibitor; anticancer; resistance; safety
(This special issue belongs to the Section Molecular Pharmacology)
Targeting Glioblastoma Metabolism submission deadline 20 Dec 2025 | 4 articles | Viewed by 11049 | Submission Open
Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation
(This special issue belongs to the Section Molecular Oncology)
Genetic Engineering of Plants for Stress Tolerance, Second Edition
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 10930 | Submission Open
Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits
(This special issue belongs to the Section Molecular Plant Sciences)
Biomarker Discovery and Validation for Precision Oncology
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 10914 | Submission Open
Keywords: biomarker discovery; biomarker validation; precision oncology; cancer screening; cancer diagnostics; liquid biopsy; multi-omics integration; targeted therapies; immunotherapy biomarkers; translational cancer research
(This special issue belongs to the Section Molecular Oncology)
Atherosclerosis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches (3rd Edition)
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 10712 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 10597 | Submission Open
Keywords: epigenetics; cancer stem cells; noncoding RNA (miRNA); personalized diagnostic (medicine); personalized medicine; DNA repair; skin cancer biomarker; skin cancer prevention; genomics; transcriptomics; immunomodulation; ctDNA; circulating tumor cells; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 10544 | Submission Open
Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking
(This special issue belongs to the Section Macromolecules)
Molecular Research in Infective Mycobacteria
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 10258 | Submission Open
Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry
(This special issue belongs to the Section Molecular Microbiology)
Nutrition as a Tool for Modulating Cellular Metabolism submission deadline 20 Dec 2025 | 2 articles | Viewed by 10227 | Submission Open
Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology
(This special issue belongs to the Section Biochemistry)
The Role of Enzymes in Metabolic Processes
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 10148 | Submission Open
Keywords: enzyme; metabolism; glycolysis; mitochondria; kinase; cell growth; carcinogenesis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 9805 | Submission Open
Keywords: sulfur compounds; sulfur metabolism; hydrogen sulfide; H2S-donors; human health; human disease; nutraceuticals
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiology of Hair Loss
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 9520 | Submission Open
Keywords: Hair Loss; Pathophysiology; Molecular Mechanisms; Genetic Mutations; Signaling Pathways; Nutrient Interactions; Personalized Therapies; Targeted Drug Delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9475 | Submission Open
Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight
(This special issue belongs to the Section Biochemistry)
Lymphatic Disorders: From Molecular Mechanisms to Therapies
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9417 | Submission Open
Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Recognition and Biosensing
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 9349 | Submission Open
Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity
(This special issue belongs to the Section Biochemistry)
Genetic Research in Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 9293 | Submission Open
Keywords: neurodegenerative diseases; genetic risk factor; next-genetation sequencing; genome-wide association studies; disease models
(This special issue belongs to the Section Molecular Neurobiology)
Diabetes: Advances in Molecular Research submission deadline 20 Dec 2025 | 3 articles | Viewed by 9265 | Submission Open
Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition submission deadline 20 Dec 2025 | 5 articles | Viewed by 9239 | Submission Open
Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex
(This special issue belongs to the Section Biochemistry)
Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment submission deadline 20 Dec 2025 | 3 articles | Viewed by 8996 | Submission Open
Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights into Redox Homeostasis and Oxidative Stress
edited by , Zoi Vasiliki Skaperda and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8754 | Submission Open
Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases
(This special issue belongs to the Section Molecular Pharmacology)
Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 8712 | Submission Open
Keywords: neurodegenerative; ALS; motor neuron; genetics; molecular pathways; biomarkers; models; treatments
(This special issue belongs to the Section Molecular Neurobiology)
Innovative Therapeutic Approaches in Neuropsychiatric Disorders
edited by Marta Pardo
submission deadline 20 Dec 2025 | 2 articles | Viewed by 8676 | Submission Open
Keywords: neuropsychiatric disorders; pharmacogenomics; pathophysiology; molecular treatment mechanisms; molecular targets for novel drug development; neurotransmitters; synaptic plasticity; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovations in Polymeric Materials: Exploring Advancements and Applications
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 8512 | Submission Open
Keywords: eco-friendly polymers; nanocomposites; biodegradable polymers; smart materials; polymer recycling; drug delivery systems; biocompatible polymers; food industry; wastewater treatment
(This special issue belongs to the Section Materials Science)
Latest Reviews in Molecular Plant Science 2025
edited by and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8485 | Submission Open
Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
New Perspective on Inflammatory Diseases: Role of Natural Compounds submission deadline 20 Dec 2025 | 4 articles | Viewed by 8184 | Submission Open
Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Synaptic Transmission and Plasticity
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8134 | Submission Open
Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases
(This special issue belongs to the Section Molecular Neurobiology)
Cancer Drug Treatment and Cancer Cell Drug Resistance submission deadline 20 Dec 2025 | 3 articles | Viewed by 7762 | Submission Open
Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition) submission deadline 20 Dec 2025 | 4 articles | Viewed by 7525 | Submission Open
Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research of Dystonia and Parkinson’s Disease
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 7417 | Submission Open
Keywords: dystonia; Parkinson’ s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition submission deadline 20 Dec 2025 | 4 articles | Viewed by 7167 | Submission Open
Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations
(This special issue belongs to the Section Molecular Oncology)
Type 2 Diabetes: Molecular Pathophysiology and Treatment
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 7090 | Submission Open
Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Targeting Macrophages in Immunotherapy
edited by Vinod Nadella
submission deadline 20 Dec 2025 | 1 articles | Viewed by 7004 | Submission Open
Keywords: tumor-associated macrophages; tumor microenvironment; tumor immunology; carcinogenesis; macrophage repolarization; checkpoint inhibitor; immunotherapy; nanomaterials; metabolic reprogramming; epigenetics
(This special issue belongs to the Section Molecular Immunology)
The Role of Neurons in Human Health and Disease—3rd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6961 | Submission Open
Keywords: brain; nervous system; neurons; immune system; human health and disease
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Multiple Sclerosis
edited by Yoshio Bando
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6526 | Submission Open
Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
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