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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention

edited by

Munish Puri

submission deadline 20 May 2026 | 2 articles | Viewed by 3545 | Submission Open

Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomedical Polymer Materials: Design, Synthesis or Applications

edited by Lourdes Franco

submission deadline 20 May 2026 | 1 articles | Viewed by 3539 | Submission Open

Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles

(This special issue belongs to the Section Materials Science)

Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions

edited by Gabriel Campolina-Silva and Héctor Contreras

submission deadline 20 May 2026 | 1 articles | Viewed by 3534 | Submission Open

Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 May 2026 | 2 articles | Viewed by 3460 | Submission Open

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA Editing/Modification in Health and Disease

edited by Valeriana Cesarini and

Piergiorgio La Rosa

submission deadline 20 May 2026 | 2 articles | Viewed by 3459 | Submission Open

Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition

edited by Taral R. Lunavat

submission deadline 20 May 2026 | 3 articles | Viewed by 3444 | Submission Open

Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights

edited by Ramos-López Omar

submission deadline 20 May 2026 | 2 articles | Viewed by 3428 | Submission Open

Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 May 2026 | 1 articles | Viewed by 3399 | Submission Open

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

Medical Applications of Polymer Materials

edited by Zhen Zhang

submission deadline 20 May 2026 | 2 articles | Viewed by 3359 | Submission Open

Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics

(This special issue belongs to the Section Macromolecules)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 20 May 2026 | 2 articles | Viewed by 3338 | Submission Open

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cyclodextrins for Drug/iRNA Co-Delivery

edited by

Ivana Jarak

and

Ana Figueiras

submission deadline 20 May 2026 | 1 articles | Viewed by 3336 | Submission Open

Keywords: advanced therapies; antibody-based therapies; active and passive tumor targeting; cancer; conventional chemotherapy; immune system; immunotherapy; immunotoxicity; nanomedicine; nanoparticles; nanotoxicity; tumor immune microenvironment (TIME); tumor microenvironment (TME); cyclodextrins

(This special issue belongs to the Section Macromolecules)

Molecular Insights into Flower Gene Regulation

edited by Wen‑Chieh Tsai

submission deadline 20 May 2026 | 2 articles | Viewed by 3215 | Submission Open

Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination

(This special issue belongs to the Section Molecular Plant Sciences)

Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond

edited by

Stephen Bustin

submission deadline 20 May 2026 | 2 articles | Viewed by 3189 | Submission Open

Keywords: MIQE; qPCR; reverse transcription

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis

edited by Katharina Proestling and

Iveta Yotova

submission deadline 20 May 2026 | 2 articles | Viewed by 3114 | Submission Open

Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Host-Virus Interaction

edited by

Xiaohui Ju

and

Xupeng Hong

submission deadline 20 May 2026 | 2 articles | Viewed by 3011 | Submission Open

Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies

(This special issue belongs to the Section Molecular Immunology)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 20 May 2026 | 1 articles | Viewed by 2867 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Lymphedema: From Mechanism to Treatment

edited by

Florent Morfoisse

submission deadline 20 May 2026 | 1 articles | Viewed by 2808 | Submission Open

Keywords: lymphedema; lymphatic dysfunction; molecular mechanisms; cell signaling; diagnostic imaging; biomarkers; therapeutic interventions; inflammation; adipose tissue accumulation; fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application

edited by

Jelena Vekic

and

Aleksandra Zeljkovic

submission deadline 20 May 2026 | 2 articles | Viewed by 2772 | Submission Open

Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity

edited by

Rui Vitorino

submission deadline 20 May 2026 | 2 articles | Viewed by 2720 | Submission Open

Keywords: cardiovascular; ischemia; heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Computational Research in Pharmacological Structure–Efficacy

edited by

José Rogério A. Silva

and Jerônimo Lameira

submission deadline 20 May 2026 | 2 articles | Viewed by 2704 | Submission Open

Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 May 2026 | 2 articles | Viewed by 2660 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Food Compounds in the Prevention and Treatment of Non-Communicable Diseases

edited by

Aneta Kopeć

submission deadline 20 May 2026 | 1 articles | Viewed by 2607 | Submission Open

Keywords: bioactive compounds; dietary fiber; polyphenols; sulfur compounds; antioxidant; reduce oxidative stress; inflammation; non-communicable diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Pathophysiology and Treatment of Eye Diseases

edited by

Georgios Panos

submission deadline 20 May 2026 | 2 articles | Viewed by 2573 | Submission Open

Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design

edited by Aleksey E. Kuznetsov

submission deadline 20 May 2026 | 2 articles | Viewed by 2530 | Submission Open

Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in the Synthesis and Medical Application of Biomaterials

edited by

Csaba Balázsi

submission deadline 20 May 2026 | 1 articles | Viewed by 2517 | Submission Open

Keywords: nanostructured biomaterials; bioceramics; bioactive; biodegradable; resorbable materials; biomimetic materials; biocompatibility

(This special issue belongs to the Section Materials Science)

Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics

edited by

Georgios Pantouris

submission deadline 20 May 2026 | 2 articles | Viewed by 2438 | Submission Open

Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity

(This special issue belongs to the Section Molecular Oncology)

Cell Organelle Stress Responses and Implications in Human Diseases

edited by

Jaeseok Han

submission deadline 20 May 2026 | 2 articles | Viewed by 2409 | Submission Open

Keywords: organelle stresses; mitochondria; ER; lysosome; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antisense Oligonucleotides: Versatile Tools with Broad Applications

edited by

Suxiang Chen

submission deadline 20 May 2026 | 2 articles | Viewed by 2392 | Submission Open

Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide

(This special issue belongs to the Section Molecular Biology)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 20 May 2026 | 2 articles | Viewed by 2388 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 May 2026 | 2 articles | Viewed by 2375 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies

edited by

Siu Hong Dexter Wong

and Bohan Yin

submission deadline 20 May 2026 | 1 articles | Viewed by 2367 | Submission Open

Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release

(This special issue belongs to the Section Macromolecules)

Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry

edited by

Yang Gao

submission deadline 20 May 2026 | 1 articles | Viewed by 2307 | Submission Open

Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry

(This special issue belongs to the Section Materials Science)

Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications

edited by Karim Daliri

submission deadline 20 May 2026 | 1 articles | Viewed by 2289 | Submission Open

Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9

(This special issue belongs to the Section Molecular Biology)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 20 May 2026 | 1 articles | Viewed by 2126 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biomaterials for Cartilage Regeneration

edited by

Valentina Vassallo

submission deadline 20 May 2026 | 1 articles | Viewed by 2099 | Submission Open

Keywords: osteoarthritis; glycosaminoglycans; biomaterials; cartilage regeneration; mesenchymal cells; chondrocytes

(This special issue belongs to the Section Biochemistry)

The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies

edited by

Jacek Baj

submission deadline 20 May 2026 | 1 articles | Viewed by 2046 | Submission Open

Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer

(This special issue belongs to the Section Molecular Oncology)

Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition

edited by

Mattia Mori

and

Ilaria Vicenti

submission deadline 20 May 2026 | 2 articles | Viewed by 2031 | Submission Open

Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs

(This special issue belongs to the Section Molecular Pharmacology)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 20 May 2026 | 2 articles | Viewed by 2006 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Research on Bioactive Natural Products: 2nd Edition

edited by

Alexandros Tsoupras

submission deadline 20 May 2026 | 1 articles | Viewed by 1951 | Submission Open

Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure– activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances and Mechanisms in Breast Cancer—2nd Edition

edited by

Ioannis Boutas

submission deadline 20 May 2026 | 2 articles | Viewed by 1941 | Submission Open

Keywords: breast cancer; genes and molecular pathways; targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Electrochemical Materials in Molecular Biology

edited by

Robert Ziółkowski

submission deadline 20 May 2026 | 1 articles | Viewed by 1931 | Submission Open

Keywords: electrochemistry; (bio)analytical chemistry; molecular biology; point-of-care; nanomaterials; (bio)molecules

(This special issue belongs to the Section Materials Science)

Osteoblast Differentiation in Human Health and Disease

edited by

Younho Han

submission deadline 20 May 2026 | 2 articles | Viewed by 1925 | Submission Open

Keywords: osteoblast differentiation; bone remodeling; mesenchymal stem cells; skeletal diseases; osteogenesis; bone mineralization; osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Advance in Infectious and Inflammatory Diseases

edited by

Justyna Agier

and

Paulina Żelechowska

submission deadline 20 May 2026 | 1 articles | Viewed by 1914 | Submission Open

Keywords: inflammatory diseases; infectious diseases; host– pathogen interactions; antimicrobial resistance; immune modulation; cytokine signaling

(This special issue belongs to the Section Molecular Microbiology)

Molecular Pathophysiology and Treatment of Coronary Artery Disease

edited by

Kazufumi Nakamura

submission deadline 20 May 2026 | 2 articles | Viewed by 1846 | Submission Open

Keywords: coronary artery disease; ischemic cardiomyopathy; immune-related adverse events; CAD associated with autoimmune diseases; coronary artery disease-related cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Pathophysiology of Myocardial Disease, 2nd Edition

edited by

Ryan D. Sullivan

Inna P. Gladysheva

and Hongyu Qiu

submission deadline 20 May 2026 | 1 articles | Viewed by 1831 | Submission Open

Keywords: myocardial disease; cardiomyopathy; fibrosis and remodeling; inflammation; hypertension; heart failure; cardiometabolic; cardio-renal; heart-liver axis; comorbidity; molecular mechanisms; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Agents: Synthesis and Design

edited by

Silvana Alfei

submission deadline 20 May 2026 | 1 articles | Viewed by 1828 | Submission Open

Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Genomics Advances in Behaviours

edited by

Péter Pikó

submission deadline 20 May 2026 | 1 articles | Viewed by 1759 | Submission Open

Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Treatment in Gastrointestinal Cancers

edited by

Dani Ran Castillo

submission deadline 20 May 2026 | 1 articles | Viewed by 1734 | Submission Open

Keywords: gastrointestinal cancers; tumor microenvironment; immune regulation; biomarkers; therapeutic resistance; liquid biopsy; targeted therapy; immune checkpoint inhibitors; epigenetic regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Novel Therapeutic Strategies for Cancers

edited by

Emanuela Grassilli

and

Maria Grazia Cerrito

submission deadline 20 May 2026 | 1 articles | Viewed by 1725 | Submission Open

Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition

edited by Sanja Dabelić

submission deadline 20 May 2026 | 2 articles | Viewed by 1687 | Submission Open

Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics

(This special issue belongs to the Section Macromolecules)

Displaying special issue 2701-2750 on page 55 of 67.

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