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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Data Science in Cancer Genomics and Precision Medicine: 2nd Edition

edited by

Apostolos Zaravinos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5006 | Submission Open

Keywords: cancer genomics; big data; tumor immunology; translational oncology; precision medicine; next-generation sequencing; omics; cancer genomic datasets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in 3D Tumor Models for Cancer Research

edited by

Simona Campora

Francesco Lopresti

and

Alessandra Lo Cicero

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4977 | Submission Open

Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4969 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases

edited by Berta Vázquez and Gerardo Ferrer

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4918 | Submission Open

Keywords: chromatin; DNA damage; DNA repair; gene transcription; DNA replication; chromosome segregation; genome integrity; chromosome organization

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights: Transitioning Fertility Research from the Laboratory to Clinical Practice

edited by Ekaterini Domali

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4878 | Submission Open

Keywords: IVF/ICSI; male infertility; female infertility; fertility outcomes; endocrine disruptors; oxidative and reductive stress; molecular biology; biomarkers; proteomics; metabolomics; and transcriptomics; cell lines; early pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Insights into Phytohormone Signaling in Plants

edited by Meng Zhang

submission deadline 20 Dec 2025 | 6 articles | Viewed by 4868 | Submission Open

Keywords: phytohormone; signal transduction; evolutionary and functional diversity; implications for plant science and agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Organic Chemistry: Molecule Synthesis and Reactions (2nd Edition)

edited by

José Justicia

and

Rachid Chahboun

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4834 | Submission Open

Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Secondary Metabolites in Plants

edited by

Sławomir Dresler

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4783 | Submission Open

Keywords: specialized metabolites; biosynthesis pathways; pharmacological applications; medicinal plants; plant stress resistance; abiotic and biotic elicitors; chemometric analysis; plant biotechnology; therapeutic potential; plant signaling and communication

(This special issue belongs to the Section Molecular Plant Sciences)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4771 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Latest Advances in Diabetes Research and Practice

edited by Ezekiel Uba Nwose

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4750 | Submission Open

Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Advances in Cancer Genomics

edited by

Yoshihito Kano

submission deadline 20 Dec 2025 | 5 articles | Viewed by 4732 | Submission Open

Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery

(This special issue belongs to the Section Molecular Biology)

Psoriasis: Molecular Research and Novel Therapy

edited by Tsen-Fang Tsai

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4706 | Submission Open

Keywords: psoriasis; pathogenesis; treatment; biologics; novel therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Understanding Molecular Mechanisms Involved in Chronic Kidney Injury and Repair

edited by

Milica Bozic

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4698 | Submission Open

Keywords: kidney disease; ischemic kidney injury; renal fibrosis; obesity; inflammation; oxidative stress; autophagy; senescence; cell death; small ncRNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Signal Transduction Mechanism in Plant Disease and Immunity: 2nd Edition

edited by

Hideo Nakashita

and

Takumi Nishiuchi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4677 | Submission Open

Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics

(This special issue belongs to the Section Molecular Plant Sciences)

Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition

edited by

Jasmin Knopf

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4663 | Submission Open

Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs

(This special issue belongs to the Section Molecular Immunology)

Pharmacological Treatment of Neuroinflammation

edited by Beatrice Polini

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4535 | Submission Open

Keywords: microglia; neuroinflammation; neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; therapeutic; natural molecules

(This special issue belongs to the Section Molecular Neurobiology)

Rapeseed: Genetic Breeding, Key Trait Mining and Genome

edited by Hongbo Chao

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4469 | Submission Open

Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Ovarian Cancer: Pathogenesis, Biomarkers and Treatment

edited by Alessandro Antonio Buda

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4398 | Submission Open

Keywords: ovarian cancer; radiotherapy; diagnosis; prevention; treatment; fertility sparing

(This special issue belongs to the Section Molecular Oncology)

Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions

edited by

Liborija Lugovic-Mihic

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4387 | Submission Open

Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antiviral Strategies Targeting Capsid Proteins: Intervention from Assembly to Function

edited by

Yuqing Wu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4257 | Submission Open

Keywords: viral capsid protein; assembly modulator/intervention; virus variants; antiviral therapeutics; assembly– disassembly

(This special issue belongs to the Section Macromolecules)

The Role of Mg Homeostasis in Disease: 2nd Edition

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4247 | Submission Open

Keywords: magnesium; chronic diseases; diabetes; bone disease; mineral metabolism; renal disease; inflammation; cardiovascular disease

(This special issue belongs to the Section Biochemistry)

Power Up Plant Genetic Research with Genomic Data: 3rd Edition

edited by

Hon-Ming Lam

Sachiko Isobe

and

Man-Wah Li

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4163 | Submission Open

Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pathophysiology and Treatment of Alzheimer's Disease

edited by

Jeffrey Fessel

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4120 | Submission Open

Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Vegetable Breeding and Molecular Research

edited by

Ai-Sheng Xiong

and

Mengyao Li

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4033 | Submission Open

Keywords: vegetable breeding; gene editing; omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Veterinary Science

edited by

JeongWoo Kang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3969 | Submission Open

Keywords: forensic pathology and necropsy; forensic toxicology; DNA analysis in veterinary forensics; the role of veterinarians in legal investigations; case studies in veterinary forensics

(This special issue belongs to the Section Molecular Toxicology)

Molecular Research on Depression—2nd Edition

edited by

Magdalena Sowa-Kućma

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3726 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

New Insights of Autophagy and Apoptosis in Cells

edited by

Mirko Pesce

and

Antonia Patruno

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3718 | Submission Open

Keywords: autophagy; apoptosis; signal transduction; cell survival

(This special issue belongs to the Section Molecular Biology)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3694 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Innovative Research on Nutrition and Epigenetics in Cancer

edited by

Marisabel Mecca

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3670 | Submission Open

Keywords: diet; nutrition; epigenetics; cancer; cancer therapy; lifestyle

(This special issue belongs to the Section Molecular Oncology)

Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition

edited by

Andreas Beineke

submission deadline 20 Dec 2025 | 4 articles | Viewed by 3575 | Submission Open

Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition

edited by Xiaogang Li

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3567 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior

edited by

Runxiang Zhang

submission deadline 20 Dec 2025 | 4 articles | Viewed by 3544 | Submission Open

Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections

edited by

Maria D'Accolti

and

Elisabetta Caselli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3492 | Submission Open

Keywords: microbial infections; AMR; molecular biology; One Health; microbiome

(This special issue belongs to the Section Molecular Microbiology)

Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact

edited by

Antonio Rescifina

and

Chiara Zagni

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3492 | Submission Open

Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products

(This special issue belongs to the Section Molecular Informatics)

Drug Delivery Systems in Veterinary Medicine: Innovations and Applications

edited by

Hualin Fu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3416 | Submission Open

Keywords: design of novel veterinary drug delivery systems; methods of preparing a veterinary drug delivery system; mechanisms of action of veterinary drug delivery systems; impact of veterinary drug delivery systems on in vivo processes of veterinary drugs; clinical evaluation of veterinary drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites

edited by

Anna Petruczynik

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3344 | Submission Open

Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques

(This special issue belongs to the Section Molecular Pharmacology)

Oxidative Stress and Inflammation in the Tissue Repair—Pathways and Biotechnologies

edited by Reggiani Vilela Gonçalves and Rômulo Dias Novaes

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3334 | Submission Open

Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; remodeling; molecular pathways; apoptotic alterations; diabetes; tissue repair

(This special issue belongs to the Section Biochemistry)

New Insight into Radiation Biology and Radiation Exposure

edited by Lynnette Cary

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3319 | Submission Open

Keywords: ionizing radiation; radiation biomarkers; radionuclide; medical countermeasure

(This special issue belongs to the Section Molecular Biology)

Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Yosep Chong

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3309 | Submission Open

Keywords: pathology; cytopathology; malignant effusions; biomarker; breast cancer; ovarian cancer; endometrial cancer; cervical cancer; metastasis; immunohistochemistry; immunocytochemistry; immunotherapy; genomics; proteomics; personalized medicine; prognosis and therapy; digital pathology; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Oncology)

New Insights into the Molecular Mechanisms of the UPR and Cell Stress

edited by

Quang Duy Trinh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3296 | Submission Open

Keywords: unfolded protein response; ER stress; oxidative stress; mitochondrial dysfunction; cell stress; stress response; UPR signaling pathway; immunity; inflammation; infection

(This special issue belongs to the Section Molecular Biology)

Extraction, Isolation and Identification of Natural Chemicals

edited by Jiaozhen Zhang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3294 | Submission Open

Keywords: extraction; isolation; identification; natural chemicals; biological activities

(This special issue belongs to the Section Biochemistry)

Future Perspectives and Challenges in Molecular Research of Glioma

edited by Shanchun Guo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3272 | Submission Open

Keywords: gliomas; genetic and epigenetic changes; molecular mechanisms; immunotherapy; innovative therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Benchmarking of Modeling and Informatic Methods in Molecular Sciences

edited by Abby Parrill

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3221 | Submission Open

Keywords: modeling; informatics; simulation; benchmarking; performance comparison; modeling method evaluation; informatic method evaluation

(This special issue belongs to the Section Molecular Informatics)

Cardioprotection and Mitochondrial Signaling: Insights from Molecular Mechanisms to Therapeutic Strategies

edited by Cecilia Zazueta

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3220 | Submission Open

Keywords: cardioprotection; mitochondrial signaling; mitochondrial dysfunction; heart failure; ischemia/reperfusion; mitochondria; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diseases in Humans and Animals: From Emergence to Translational Medicine

edited by

Pawel Kordowitzki

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3111 | Submission Open

Keywords: animal diseases; human diseases; viruses; bacteria; translational medicine; environment; zoonosis; One Health; disease models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrating Molecular Insights on Plant Microbes and Insect Pests

edited by

Xifeng Wang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2981 | Submission Open

Keywords: pathogenic microbes; resistance mechanisms; signaling pathways; omics technologies; plant and insect interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Osteoarthritis: From Pathophysiology to Novel Therapy

edited by

Paloma Guillem-Llobat

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2907 | Submission Open

Keywords: osteoarthritis; therapeutic targets; molecular mechanisms; biomarkers; bone degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Radiopharmaceuticals and Radiotherapy

edited by Feifei An

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2838 | Submission Open

Keywords: positron emission tomography; single photon emission computed tomography; boron neutron capture therapy; alfa-particle; radiopharmaceutical; radiotherapy; radiosensitizer; Cu-67; Lu-177; I-131; Ac-225; Pb-212; At-211

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics

edited by Clinton B. Mathias and Michiko K. Oyoshi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2824 | Submission Open

Keywords: food allergy; allergic mechanisms; asthma; allergic disease; mast cells; ILC2s; Th2 cells; eosinophils; IL-4; IL-33; IL-13

(This special issue belongs to the Section Molecular Immunology)

DNA Virus Infection: HPV-Related Cancers, Pathology, Biomarkers and Immunotherapy

edited by

Dimitris Tsakogiannis

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2805 | Submission Open

Keywords: HPV; molecular diagnostics; HPV ctDNA; cancer; mutations; viral oncogenicity; immunotherapy; biomarkers; oncology; cancer treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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