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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5093 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

Psoriasis: Molecular Research and Novel Therapy

edited by Tsen-Fang Tsai

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5016 | Submission Open

Keywords: psoriasis; pathogenesis; treatment; biologics; novel therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Organic Chemistry: Molecule Synthesis and Reactions (2nd Edition)

edited by

José Justicia

and

Rachid Chahboun

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4992 | Submission Open

Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Secondary Metabolites in Plants

edited by

Sławomir Dresler

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4959 | Submission Open

Keywords: specialized metabolites; biosynthesis pathways; pharmacological applications; medicinal plants; plant stress resistance; abiotic and biotic elicitors; chemometric analysis; plant biotechnology; therapeutic potential; plant signaling and communication

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Understanding Molecular Mechanisms Involved in Chronic Kidney Injury and Repair

edited by

Milica Bozic

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4827 | Submission Open

Keywords: kidney disease; ischemic kidney injury; renal fibrosis; obesity; inflammation; oxidative stress; autophagy; senescence; cell death; small ncRNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition

edited by

Jasmin Knopf

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4810 | Submission Open

Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs

(This special issue belongs to the Section Molecular Immunology)

Signal Transduction Mechanism in Plant Disease and Immunity: 2nd Edition

edited by

Hideo Nakashita

and

Takumi Nishiuchi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4732 | Submission Open

Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics

(This special issue belongs to the Section Molecular Plant Sciences)

Pharmacological Treatment of Neuroinflammation

edited by Beatrice Polini

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4676 | Submission Open

Keywords: microglia; neuroinflammation; neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; therapeutic; natural molecules

(This special issue belongs to the Section Molecular Neurobiology)

Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions

edited by

Liborija Lugovic-Mihic

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4665 | Submission Open

Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Mg Homeostasis in Disease: 2nd Edition

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4654 | Submission Open

Keywords: magnesium; chronic diseases; diabetes; bone disease; mineral metabolism; renal disease; inflammation; cardiovascular disease

(This special issue belongs to the Section Biochemistry)

Rapeseed: Genetic Breeding, Key Trait Mining and Genome

edited by Hongbo Chao

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4645 | Submission Open

Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Antiviral Strategies Targeting Capsid Proteins: Intervention from Assembly to Function

edited by

Yuqing Wu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4454 | Submission Open

Keywords: viral capsid protein; assembly modulator/intervention; virus variants; antiviral therapeutics; assembly– disassembly

(This special issue belongs to the Section Macromolecules)

Advances in Vegetable Breeding and Molecular Research

edited by

Ai-Sheng Xiong

and

Mengyao Li

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4247 | Submission Open

Keywords: vegetable breeding; gene editing; omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Pathophysiology and Treatment of Alzheimer's Disease

edited by

Jeffrey Fessel

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4180 | Submission Open

Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Depression—2nd Edition

edited by

Magdalena Sowa-Kućma

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4158 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition

edited by

Andreas Beineke

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4142 | Submission Open

Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Veterinary Science

edited by

JeongWoo Kang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4088 | Submission Open

Keywords: forensic pathology and necropsy; forensic toxicology; DNA analysis in veterinary forensics; the role of veterinarians in legal investigations; case studies in veterinary forensics

(This special issue belongs to the Section Molecular Toxicology)

New Insights of Autophagy and Apoptosis in Cells

edited by

Mirko Pesce

and

Antonia Patruno

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3989 | Submission Open

Keywords: autophagy; apoptosis; signal transduction; cell survival

(This special issue belongs to the Section Molecular Biology)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3797 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition

edited by Xiaogang Li

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3783 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Innovative Research on Nutrition and Epigenetics in Cancer

edited by

Marisabel Mecca

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3779 | Submission Open

Keywords: diet; nutrition; epigenetics; cancer; cancer therapy; lifestyle

(This special issue belongs to the Section Molecular Oncology)

Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact

edited by

Antonio Rescifina

and

Chiara Zagni

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3694 | Submission Open

Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products

(This special issue belongs to the Section Molecular Informatics)

Drug Delivery Systems in Veterinary Medicine: Innovations and Applications

edited by

Hualin Fu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3672 | Submission Open

Keywords: design of novel veterinary drug delivery systems; methods of preparing a veterinary drug delivery system; mechanisms of action of veterinary drug delivery systems; impact of veterinary drug delivery systems on in vivo processes of veterinary drugs; clinical evaluation of veterinary drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

New Insights into the Molecular Mechanisms of the UPR and Cell Stress

edited by

Quang Duy Trinh

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3658 | Submission Open

Keywords: unfolded protein response; ER stress; oxidative stress; mitochondrial dysfunction; cell stress; stress response; UPR signaling pathway; immunity; inflammation; infection

(This special issue belongs to the Section Molecular Biology)

The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections

edited by

Maria D'Accolti

and

Elisabetta Caselli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3602 | Submission Open

Keywords: microbial infections; AMR; molecular biology; One Health; microbiome

(This special issue belongs to the Section Molecular Microbiology)

Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites

edited by

Anna Petruczynik

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3543 | Submission Open

Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques

(This special issue belongs to the Section Molecular Pharmacology)

Future Perspectives and Challenges in Molecular Research of Glioma

edited by Shanchun Guo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3470 | Submission Open

Keywords: gliomas; genetic and epigenetic changes; molecular mechanisms; immunotherapy; innovative therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Benchmarking of Modeling and Informatic Methods in Molecular Sciences

edited by Abby Parrill

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3434 | Submission Open

Keywords: modeling; informatics; simulation; benchmarking; performance comparison; modeling method evaluation; informatic method evaluation

(This special issue belongs to the Section Molecular Informatics)

New Insight into Radiation Biology and Radiation Exposure

edited by Lynnette Cary

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3423 | Submission Open

Keywords: ionizing radiation; radiation biomarkers; radionuclide; medical countermeasure

(This special issue belongs to the Section Molecular Biology)

Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Yosep Chong

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3408 | Submission Open

Keywords: pathology; cytopathology; malignant effusions; biomarker; breast cancer; ovarian cancer; endometrial cancer; cervical cancer; metastasis; immunohistochemistry; immunocytochemistry; immunotherapy; genomics; proteomics; personalized medicine; prognosis and therapy; digital pathology; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Oncology)

Extraction, Isolation and Identification of Natural Chemicals

edited by Jiaozhen Zhang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3401 | Submission Open

Keywords: extraction; isolation; identification; natural chemicals; biological activities

(This special issue belongs to the Section Biochemistry)

Oxidative Stress and Inflammation in the Tissue Repair—Pathways and Biotechnologies

edited by Reggiani Vilela Gonçalves and Rômulo Dias Novaes

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3384 | Submission Open

Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; remodeling; molecular pathways; apoptotic alterations; diabetes; tissue repair

(This special issue belongs to the Section Biochemistry)

Cardioprotection and Mitochondrial Signaling: Insights from Molecular Mechanisms to Therapeutic Strategies

edited by Cecilia Zazueta

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3322 | Submission Open

Keywords: cardioprotection; mitochondrial signaling; mitochondrial dysfunction; heart failure; ischemia/reperfusion; mitochondria; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diseases in Humans and Animals: From Emergence to Translational Medicine

edited by

Pawel Kordowitzki

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3172 | Submission Open

Keywords: animal diseases; human diseases; viruses; bacteria; translational medicine; environment; zoonosis; One Health; disease models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrating Molecular Insights on Plant Microbes and Insect Pests

edited by

Xifeng Wang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3058 | Submission Open

Keywords: pathogenic microbes; resistance mechanisms; signaling pathways; omics technologies; plant and insect interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Imaging Molecules in Biomedical Research

edited by

Manuela Malatesta

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2922 | Submission Open

Keywords: biomedicine; histochemistry; immunohistochemistry; in situ hybridization; magnetic resonance imaging; optical imaging; photoacoustic imaging; ultrasound imaging; Raman microscopy

(This special issue belongs to the Section Biochemistry)

New Advances in Radiopharmaceuticals and Radiotherapy

edited by Feifei An

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2913 | Submission Open

Keywords: positron emission tomography; single photon emission computed tomography; boron neutron capture therapy; alfa-particle; radiopharmaceutical; radiotherapy; radiosensitizer; Cu-67; Lu-177; I-131; Ac-225; Pb-212; At-211

(This special issue belongs to the Section Molecular Pharmacology)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Dec 2025 | 4 articles | Viewed by 2898 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Cell Cycle-Related Proteins: Biochemical Regulative/Deregulative Mechanisms

edited by

Emanuela Stampone

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2850 | Submission Open

Keywords: cell cycle; cell division; cyclins; cyclin-dependent kinases (CDKs); biochemical regulative mechanisms

(This special issue belongs to the Section Biochemistry)

Naturally Occurring Bioactive Compounds, Neuroinflammation and Cognitive Dysfunction: Molecular and Biochemical Mechanisms

edited by

Tosin Olasehinde

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2844 | Submission Open

Keywords: neuroinflammation; cognitive dysfunction; medicinal plants; bioactive compounds; neurodegenerative diseases; molecular mechanisms; anti-inflammatory

(This special issue belongs to the Section Molecular Toxicology)

DNA Virus Infection: HPV-Related Cancers, Pathology, Biomarkers and Immunotherapy

edited by

Dimitris Tsakogiannis

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2841 | Submission Open

Keywords: HPV; molecular diagnostics; HPV ctDNA; cancer; mutations; viral oncogenicity; immunotherapy; biomarkers; oncology; cancer treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Thyroid Hormone in Health and Disease

edited by Sandra Incerpi and Jens Z. Pedersen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2750 | Submission Open

Keywords: nongenomic effects; integrin α vβ 3; crosstalk; signal transduction; metabolites; 3; 5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress; stilbene derivatives

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Genetics and Breeding for Sugar Crops

edited by Muqing Zhang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2729 | Submission Open

Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene

(This special issue belongs to the Section Molecular Plant Sciences)

Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases

edited by

Takuro Miyazaki

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2616 | Submission Open

Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase

(This special issue belongs to the Section Molecular Biology)

Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

edited by

Jianqiang Xu

and

Yanshuo Han

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2586 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2559 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Challenges in Molecularly Imprinted Materials

edited by

Monika Sobiech

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2537 | Submission Open

Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization

(This special issue belongs to the Section Materials Science)

Molecular Research on Rhizobia

edited by

Socorro Mesa

, María J. Delgado and

Germán Tortosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2431 | Submission Open

Keywords: biodiversity; environmental factors; plant– rhizobia interaction; nitrogen fixation; regulation; signaling; symbiosis

(This special issue belongs to the Section Molecular Microbiology)

Autophagic Related Proteins in Cancer

edited by Pietri Puustinen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2334 | Submission Open

Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress and Mitochondria in Human Diseases

edited by

Alejandra Espinosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2257 | Submission Open

Keywords: mitochondrial dynamics; ROS; antioxidants; mitophagy; oxidative damage; lipid peroxidation; neurodegenerative diseases; cancer; obesity

(This special issue belongs to the Section Biochemistry)

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