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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Structural and Functional Insights into Membrane Transporters: A Tribute to Dr. Ernest Wright
edited by Jeff Abramson
submission deadline 20 Apr 2026 | 3 articles | Viewed by 3437 | Submission Open
Keywords: membrane transporters; membrane protein; glucose transport; cell membrane; interface reaction
(This special issue belongs to the Section Molecular Biology)
New Insights into Osteoclasts
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 3401 | Submission Open
Keywords: osteoclast; bone remodeling; osteoporosis; inflammatory arthritis; bone tumor
(This special issue belongs to the Section Molecular Biology)
Latest Advances in Cytokine Storm
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 3384 | Submission Open
Keywords: cytokine storm; cytokine release syndrome; inflammatory; protective immunity; multi-drug resistant bacterial strains
(This special issue belongs to the Section Molecular Immunology)
Role of Extracellular Vesicles in Immunology: Second Edition
edited by and Valeria Longo
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3349 | Submission Open
Keywords: extracellular vesicles; exosomes; microvesicles; apoptotic bodies; cytokines; immunological response; immune system
(This special issue belongs to the Section Molecular Immunology)
Cyclodextrins: Properties and Applications, 3rd Edition submission deadline 20 Apr 2026 | 5 articles | Viewed by 3321 | Submission Open
Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties
(This special issue belongs to the Section Macromolecules)
The Roles of Mesenchymal Stem/Stromal Cells in Tumor Therapies
edited by Francesco Agostini
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3290 | Submission Open
Keywords: mesenchymal stem cells; tumor; cancer patients; ex vivo cell modification; cell and gene therapy; targeted drug delivery; homing; migration; current regulatory guidelines; MSC therapeutic potential
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Liver Disease and Hepatocellular Carcinoma—2nd Edition
edited by and Sara Carpi
submission deadline 20 Apr 2026 | 2 articles | Viewed by 3258 | Submission Open
Keywords: hepatocellular carcinoma; NAFLD/NASH; viral hepatitis; autoimmune liver disease; immunotherapy; biomarker
(This special issue belongs to the Section Molecular Oncology)
Molecular Breeding of Plants: From CRISPR/Cas9 to Transcriptomics and MABc
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3251 | Submission Open
Keywords: CRISPR/Cas9; transcriptomics; marker-assisted breeding; genome editing; plant genetics; gene expression; plant genomics; quantitative trait loci (QTL); crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition) submission deadline 20 Apr 2026 | 3 articles | Viewed by 3214 | Submission Open
Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Developmental and Reproductive Toxicology
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3207 | Submission Open
Keywords: spermatogenesis; mouse models; reproduction biology; assisted reproductive technology; cell signaling; cellular biology; developmental biology
(This special issue belongs to the Section Molecular Biology)
Research on Mitochondrial Genetics and Epigenetics
edited by Arianna Montanari
submission deadline 20 Apr 2026 | 2 articles | Viewed by 3139 | Submission Open
Keywords: mitochondrial DNA dynamics; retrograde regulation; epigenetic modulators; mitochondrial diseases; cellular homeostasis
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Endothelial Cell Injury and Repair submission deadline 20 Apr 2026 | 2 articles | Viewed by 3126 | Submission Open
Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnosis and Treatments of Diabetes Mellitus: 2nd Edition submission deadline 20 Apr 2026 | 4 articles | Viewed by 3056 | Submission Open
Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Signatures in Autism Spectrum Disorders
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3039 | Submission Open
Keywords: epigenetics; ncRNA; mRNA; cytokines; mitochondria; inflammation; autism
(This special issue belongs to the Section Molecular Neurobiology)
Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives
edited by Muhammad Y. Sheikh
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3007 | Submission Open
Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Biomathematics, Computational Biology, and Bioengineering submission deadline 20 Apr 2026 | 5 articles | Viewed by 2995 | Submission Open
Keywords: biomathematics; machine learning; artificial intelligence; data science; systems biology; reaction– diffusion systems; nonlinear dynamics; bioreactors; biochemical reaction engineering
(This special issue belongs to the Section Molecular Informatics)
Molecular Research on Neuroinflammation and Brain Aging
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2993 | Submission Open
Keywords: neurotoxicology; aging; Alzheimer's disease; neurodegenerative diseases; inflammatory
(This special issue belongs to the Section Molecular Toxicology)
Molecular Characterization and Applications of Nanomaterials in Nanomedicine and Cancer Therapy
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2988 | Submission Open
Keywords: nanomaterials (preparation methods; characterization techniques; properties); theoretical studies of nanomaterials and computational simulations; biocompatibility and biofunctionalization; applications in nanomedicine; applications in cancer therapy; drug delivery; nanoparticle imaging; magnetic resonance imaging (MRI); contrast agents; nanotheranostics
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Research in Skin Health and Disease
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2943 | Submission Open
Keywords: wound healing; molecular research in skin lesions; dermatologic surgery; cosmetic surgery; exosomes: new molecular targets of diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds of Natural Origin: 2nd Edition
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 2919 | Submission Open
Keywords: plants; extraction methods; bioactive compounds; natural products; application
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Fungal Pathogen-Host Interactions
edited by Patricia Albuquerque
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2909 | Submission Open
Keywords: medical mycology; host– microbe interactions; macrophages; dendritic cells; neutrophils
(This special issue belongs to the Section Molecular Microbiology)
New Insights and Discoveries in the Pathogenesis, Diagnosis and Therapy of Neuromuscular Diseases
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2909 | Submission Open
Keywords: neuromuscular diseases; autophagy; mitochondrial dysfunction; molecular genetics; blood-based biomarkers; antisense oligonucleotides; monoclonal antibodies
(This special issue belongs to the Section Molecular Neurobiology)
Microbiota’s Role in Respiratory Disorders and Diseases
edited by and Mauro Carone
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2897 | Submission Open
Keywords: microbiota; microbiome; metabolome; transcriptome; microbiota gut/lung axis; microbiota gut/oral axis; respiratory disorders; respiratory diseases; respiratory rehabilitation
(This special issue belongs to the Section Molecular Microbiology)
Sarcomas: From Molecular Insights to Personalized Therapies
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2889 | Submission Open
Keywords: soft tissue sarcoma; biomarkers; molecular mechanisms; experimental models; clinical factors associated with sarcoma development
(This special issue belongs to the Section Molecular Oncology)
Bone and Cartilage Injury and Repair: Molecular Aspects
edited by Silvia María Díaz-Prado
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2809 | Submission Open
Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers
(This special issue belongs to the Section Molecular Biology)
Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches
edited by Francisco Giner
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2803 | Submission Open
Keywords: coeliac disease; microscopic colitis; Crohn’ s disease; ulcerative colitis; microbiota; biological therapies; refractory disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthetic Chemistry in Drug Discovery
edited by Kathiravan Suppan
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2761 | Submission Open
Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Treatment of Chronic Kidney Disease
edited by Xinming Chen
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2667 | Submission Open
Keywords: diabetes; cardiovascular diseases; nephrology; diabetic nephropathy
(This special issue belongs to the Section Molecular Biology)
Radiobiology—New Advances submission deadline 20 Apr 2026 | 1 articles | Viewed by 2666 | Submission Open
Keywords: radiobiology; radiotherapy; radiosensitizing agents; radioresistance; DNA damage; FLASH radiotherapy; particle therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Triple-Negative Breast Cancer: 2nd Edition
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2664 | Submission Open
Keywords: triple negative breast cancer; lymph node metastasis; PMP22; prediction model using deep learning
(This special issue belongs to the Section Molecular Oncology)
Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential submission deadline 20 Apr 2026 | 1 articles | Viewed by 2644 | Submission Open
Keywords: natural compounds; cancer research; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Mitochondria and Energy Metabolism Reprogramming in Diseases
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2617 | Submission Open
Keywords: mitochondrial dysfunctions; energy metabolism; pathophysiological mechanisms; therapeutic targets; physiology of organelle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of the Endocannabinoid System in Reward- and Addiction-Related Neuroplasticity submission deadline 20 Apr 2026 | 1 articles | Viewed by 2565 | Submission Open
Keywords: endocannabinoid system; neuroplasticity; reward; addiction; biomarker; therapeutic approach
(This special issue belongs to the Section Molecular Neurobiology)
COVID-19: Molecular Research and Novel Therapy submission deadline 20 Apr 2026 | 2 articles | Viewed by 2543 | Submission Open
Keywords: SARS-CoV-2; virus-host interaction; immune response; antiviral agents; vaccines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Explore Marine Biodiversity: Discover Insights from Genomics and Transcriptomics
edited by and Ambrosino Luca
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2477 | Submission Open
Keywords: comparative genomics; functional genomics; transcriptomics; gene expression; adaptation; population genomics; marine biodiversity; evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advanced Molecular Research in Cardiology and Treatment Approaches
edited by Ludger Hauck
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2436 | Submission Open
Keywords: TAp63; EzH2; histone methyltransferase; cardiomyocyte proliferation; myocardial infarction; heart regeneration; heart repair; epigenetic regulation; cardiac regeneration; Skp2-p27KIP1 pathway
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Luminescent Materials and Their Luminescence Mechanism submission deadline 20 Apr 2026 | 2 articles | Viewed by 2398 | Submission Open
Keywords: luminescence; molecular/ionic level; mechanism
(This special issue belongs to the Section Materials Science)
Molecular and Genomic Aspects of Viral Pathogens submission deadline 20 Apr 2026 | 2 articles | Viewed by 2380 | Submission Open
Keywords: viral pathogens; genetic and molecular mechanisms; viral infection; viral replication; host interaction
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights into Microbial Dynamics in Agroforestry for Resilience and Climate Adaptation submission deadline 20 Apr 2026 | 1 articles | Viewed by 2318 | Submission Open
Keywords: agroforestry; soil microbes; plant-microbe interactions; microbial influence; microbiomes; insect-microbe interactions; horizontal gene transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Zebrafish Model for Neurological Research
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2312 | Submission Open
Keywords: zebrafish  ; Danio rerio  ; brain  ; nervous system
(This special issue belongs to the Section Molecular Neurobiology)
New Insights and Research on Nutrition and Obesity
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2267 | Submission Open
Keywords: nutrition; obesity; malnutrition; overnutrition; molecular and cellular mechanisms; nutrient– gene interactions; metabolic disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Molecular Diagnostic Approaches for Neurodevelopmental Disorders: Applications and Future Perspectives
edited by and Michele Pinelli
submission deadline 20 Apr 2026 | 3 articles | Viewed by 2209 | Submission Open
Keywords: neurodevelopmental disorders; array CGH; NGS
(This special issue belongs to the Section Molecular Neurobiology)
Current Trends in Redox Physiology Research
edited by Fotios Tekos
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2209 | Submission Open
Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers
(This special issue belongs to the Section Biochemistry)
Genetic Prediction of Risk of Common Diseases
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2126 | Submission Open
Keywords: complex genetic diseases; cancer; heart disease; diabetes; dementia; polygenic risk score; genetic risk signatures
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into Ubiquitination and Deubiquitination in Plants
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2105 | Submission Open
Keywords: ubiquitin; E1; E2; E3; deubiquitination; proteolysis; plants
(This special issue belongs to the Section Biochemistry)
Complex Interactions of Plants with Other Organisms: Particular Attention to Carnivorous and Parasitic Plants submission deadline 20 Apr 2026 | 1 articles | Viewed by 2073 | Submission Open
Keywords: carnivorous plants; parasitic plants; mycotrophic plants; hosts; phytochemistry; molecular biology; genome evolution; organ structure; cellular; genomic
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Microbial Genomics: Insights from Whole Genomes and Metagenomes submission deadline 20 Apr 2026 | 2 articles | Viewed by 1988 | Submission Open
Keywords: microbial evolution; whole-genome sequencing; metagenomics; horizontal gene transfer; antimicrobial resistance; computational genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cellular and Molecular Mechanisms in Inflammatory Bowel Disease
edited by Michael Bording-Jorgensen
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1986 | Submission Open
Keywords: IBD; cytokines; microbiome; Crohn’ s disease; ulcerative colitis; dysbiosis; mucosal immunity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Molecular Science, Material Analysis, and Surface Treatments: Paving the Way for Future Technological Innovations
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1969 | Submission Open
Keywords: materials; surface treatments; corrosion; nanomaterials; coatings; molecular interactions; deposition
(This special issue belongs to the Section Materials Science)
Advancement of Understanding Alzheimer’s Disease Susceptibility and Novel Drug Targets
edited by Kunie Ando and Jean-Pierre Brion
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1962 | Submission Open
Keywords: Alzheimer’ s disease; neurodegenerative diseases; tau; amyloid; inflammation; disease modifying treatments; biomarkers; genetic variants; risk factors; mechanisms; protein– protein interactions; post-translational modifications
(This special issue belongs to the Section Molecular Neurobiology)
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