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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exosomes and Extracellular Vesicles in Health and Diseases: 4th Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Omics Insights into Stress Responses and Adaptation in Fish

edited by

Zongbin Cui

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: fish stress adaptation; environmental stressors; omics integration; molecular mechanisms; functional genomics; epigenetic regulation; systems biology; stress resilience

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research in Animal Reproduction

edited by

He Huang

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: animal reproduction; molecular regulation; spermatogenesis; embryonic development; epigenetics; reproductive hormones; oogenesis; environmental factors

(This special issue belongs to the Section Molecular Biology)

Molecular Advances on Pathogen Interaction and Host Immune

edited by

Karolina Kot

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: host– pathogen interactions; innate and adaptive immunity; pattern recognition receptors (PRRs); immune signaling pathways; cytokines and interferons; immune evasion mechanisms; molecular pathogenesis; infectious diseases

(This special issue belongs to the Section Molecular Immunology)

Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions

edited by Adelina-Gabriela Niculescu and

Ariana Hudita

submission deadline 30 Jun 2026 | Submission Open

Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications

(This special issue belongs to the Section Molecular Nanoscience)

New Perspectives and Challenges in the Mechanisms, Diagnosis and Management of Skin Diseases

edited by

Emanuela Bastonini

, Daniela Kovacs and

Giorgia Cardinali

submission deadline 30 Jun 2026 | Submission Open

Keywords: skin diseases; precision medicine; molecular pathogenesis; regenerative medicine; lipidomics; targeted biologics; inflammatory skin diseases; skin cancers; skin aging; gut– skin axis; skin regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Cotton Breeding and Genetics

edited by

Yanpeng Zhao

submission deadline 30 Jun 2026 | Submission Open

Keywords: cotton genomics; molecular breeding; gene regulation; abiotic stress tolerance; fiber quality improvement; disease resistance; genetic engineering; marker-assisted selection; transcriptomics; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Adipose Tissue Dysfunction

edited by

Stefano Quarta

submission deadline 30 Jun 2026 | Submission Open

Keywords: adipose tissue dysfunction; adipogenesis; immunometabolism and adipokines; mitochondrial dysfunction; extracellular vesicles; fibrosis and ECM remodeling; lipid metabolism; browning and beigeing; metabolic biomarkers and therapeutic targets; adipose-derived stem cells

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Molecular Ecology and Genomic Perspectives

edited by

Peng Zhao

submission deadline 1 Jul 2026 | Viewed by 269 | Submission Open

Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Physiopathological Role of Hypoxia

edited by

Michele Aventaggiato

submission deadline 10 Jul 2026 | Viewed by 61 | Submission Open

Keywords: hypoxia; cell metabolism; inflammation; tumor microenvironment; cancer progression; EMT; chronic inflammation; obesity; inflammatory microenvironment; storage disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breast Cancer: From Molecular Mechanism to Therapeutic Strategy

edited by

Anna Makuch-Kocka

submission deadline 10 Jul 2026 | Viewed by 51 | Submission Open

Keywords: breast cancer; molecular mechanisms; therapeutic strategies; tumor microenvironment; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Structure and Characterization of Optical Materials

edited by

Andrzej Kruk

submission deadline 10 Jul 2026 | Viewed by 39 | Submission Open

Keywords: luminescence; structure modification; spectroscopy; measurement techniques; Kerr effect; Faraday effects; doping; molecular structure

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanism of Circadian Rhythm

edited by Rosângela Vieira de Andrade

submission deadline 20 Jul 2026 | 3 articles | Viewed by 29372 | Submission Open

Keywords: circadian cycle; exercise; aging; clock genes; health

(This special issue belongs to the Section Molecular Biology)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Jul 2026 | 7 articles | Viewed by 25248 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Interplay Between the Human Microbiome and Diseases

edited by

Tihamer Molnar

and

Zoltán Péterfi

submission deadline 20 Jul 2026 | 9 articles | Viewed by 17438 | Submission Open

Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Jul 2026 | 5 articles | Viewed by 11011 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Progression of Genome-Related Diseases: 2nd Edition

edited by

Salvatore Saccone

submission deadline 20 Jul 2026 | 3 articles | Viewed by 10051 | Submission Open

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 20 Jul 2026 | 5 articles | Viewed by 8550 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass

edited by

Ana Lima

and

Elisabete Maria de Castro Lima

submission deadline 20 Jul 2026 | 3 articles | Viewed by 8145 | Submission Open

Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization

(This special issue belongs to the Section Biochemistry)

Hypoxia: Molecular Mechanism and Health Effects

edited by

Pinar Uysal-Onganer

submission deadline 20 Jul 2026 | 4 articles | Viewed by 5909 | Submission Open

Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Glioblastoma Pathogenesis and Therapeutics

edited by

Claudia Desiderio

Giovanni Sabatino

and

Edoardo Mazzucchi

submission deadline 20 Jul 2026 | 3 articles | Viewed by 5825 | Submission Open

Keywords: glioblastoma; proteomics; immunopeptidomics; genomics; extracellular vesicles; biomarkers; molecular mechanisms; i-knife mass spectrometry; intra-operative imaging; cancer stem cells; cancer progression; neurosurgery; radiomics; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 20 Jul 2026 | 5 articles | Viewed by 5199 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Jul 2026 | 3 articles | Viewed by 4964 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Power Up Plant Genetic Research with Genomic Data: 3rd Edition

edited by

Hon-Ming Lam

Sachiko Isobe

and

Man-Wah Li

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4307 | Submission Open

Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 20 Jul 2026 | 1 articles | Viewed by 3146 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Addiction

edited by

Aleksandra Suchanecka

and

Jolanta Chmielowiec

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2857 | Submission Open

Keywords: addiction; dependence; neurobiology; reward; neuroplasticity; biostatistics

(This special issue belongs to the Section Molecular Neurobiology)

Research Progress in Cellular Senescence in Health and Disease

edited by

Gabriella Teti

and Mirella Falconi

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2627 | Submission Open

Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Biology on Mycobacteria: 2nd Edition

edited by

Rita Macedo

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2559 | Submission Open

Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction

(This special issue belongs to the Section Molecular Microbiology)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2297 | Submission Open

Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

Recent Advances in Gastrointestinal Cancer, 3rd Edition

edited by

Aneta Koronowicz

submission deadline 20 Jul 2026 | 1 articles | Viewed by 2225 | Submission Open

Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Sjögren's Syndrome, 4th Edition

edited by

Biji Theyilamannil Kurien

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2084 | Submission Open

Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in Neurodegenerative Diseases

edited by

Silvia Lima Costa

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1874 | Submission Open

Keywords: bioactive compounds; neurodegenerative diseases; neuroinflammation; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Supplements and Drug-Based Strategies in Neonatal and Paediatric Health

edited by

Giulia Malaguarnera

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1600 | Submission Open

Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota– host interactions; infectious diseases in children; neurodevelopmental disorders; drug– nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer

edited by Rebecca Chin

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1433 | Submission Open

Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Governing Lipid Metabolism in Health and Disease

edited by

Christina E. Kostara

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1325 | Submission Open

Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs

edited by

Yoshihiro Uesawa

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1314 | Submission Open

Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database

(This special issue belongs to the Section Molecular Pharmacology)

Recent Nanotechnology in Drug Delivery

edited by

Omar Mertins

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1271 | Submission Open

Keywords: smart nanoparticles; hybrid nanomaterial; functionalization; drug targeting; liposome; cubosome; polypeptide; polymers; biomolecules; cancer; vaccine; antimicrobial; antiparasite; antioxidant; immunomodulatory; genetic therapy; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition

edited by

Marko Tarle

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1208 | Submission Open

Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology

(This special issue belongs to the Section Molecular Oncology)

Nanoparticle-Based Biosensors and Their Applications

edited by

Edyta Proniewicz

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1151 | Submission Open

Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology

(This special issue belongs to the Section Molecular Nanoscience)

Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making

edited by

Maria Beatrice Morelli

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1139 | Submission Open

Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics

edited by

Vladimir N. Uversky

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1020 | Submission Open

Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography

(This special issue belongs to the Section Molecular Biophysics)

G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition

edited by

Joanna Filipowska

submission deadline 20 Jul 2026 | 1 articles | Viewed by 580 | Submission Open

Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode

(This special issue belongs to the Section Molecular Pharmacology)

Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment

edited by

Deborah J. Good

submission deadline 20 Jul 2026 | Viewed by 521 | Submission Open

Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathophysiology of Chronic Lung Diseases: Mechanisms and Therapeutics

edited by Gary C. Mouradian

submission deadline 20 Jul 2026 | 1 articles | Viewed by 454 | Submission Open

Keywords: chronic lung disease; vagal sensory neurons; inflammation; airway remodeling; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nucleic Acid Aptamers in Molecular Medicine

edited by

Silvia Catuogno

submission deadline 20 Jul 2026 | Viewed by 411 | Submission Open

Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery

(This special issue belongs to the Section Molecular Biology)

Neuronal Differentiation: From Pathology to Therapeutic Strategies

edited by

Marzia Lecchi

submission deadline 20 Jul 2026 | Viewed by 363 | Submission Open

Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Medical Microbiology and Infectious Diseases: The Role of Artificial Intelligence and Machine Learning

edited by

Alberto Rizzo

submission deadline 20 Jul 2026 | Viewed by 212 | Submission Open

Keywords: molecular diagnostics; pathogen genomics; antimicrobial resistance; host– pathogen interaction; infectious diseases surveillance; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Informatics)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 20 Jul 2026 | Viewed by 211 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Non-Coding RNAs as Key Regulators in Human Disease Processes

edited by

Beatrice Polini

submission deadline 20 Jul 2026 | Viewed by 182 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Small Molecules in Tissue Repair and Regeneration

edited by

Ildiko Bock-Marquette

submission deadline 20 Jul 2026 | Viewed by 179 | Submission Open

Keywords: small molecules; organ and tissue regeneration; development; aging