G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 49
Special Issue Editor
Interests: G protein-coupled receptor; bone regeneration; mesenchymal stem cells; diabetes; pancreatic beta cell regeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
G protein-coupled receptors (GPCRs) are the largest and most diverse family of membrane receptors in eukaryotic cells. These seven-transmembrane domain proteins are activated by a wide range of ligands—e.g., hormones, neurotransmitters, ions, and sensory stimuli—triggering downstream signaling cascades through heterotrimeric G proteins. GPCRs regulate numerous physiological processes such as vision, taste, smell, immune responses, and neurotransmission.
The plethora of processes regulated by GPCRs makes them critical targets for therapeutic intervention. Approximately one-third of all clinically approved drugs act through the modulation of GPCR-mediated signaling. Yet, many aspects of GPCR signaling are still not fully understood, particularly regarding receptor specificity, biased signaling, and the spatiotemporal dynamics of receptor activation and desensitization.
Advances in structural biology, computational modeling, and high-throughput screening have significantly expanded our understanding of GPCR pharmacology, opening new avenues for drug discovery and precision medicine.
This research topic aims to further elucidate the molecular mechanisms governing GPCR activity and their implications in health and disease, emphasizing the role of these receptors in different systems and tissues. A thorough understanding of GPCR-mediated pathways may play a critical role in the development of effective therapeutic approaches.
Dr. Joanna Filipowska
Guest Editor
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Keywords
- GPCR
- cell signaling
- small-molecule drugs
- biased signaling
- endosomal signaling
- post-translational modification
- GPCR internalization
- phosphorylation barcode
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