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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring the Functional Activity of Natural Products

edited by

Antonio Speciale

submission deadline 31 May 2026 | Viewed by 44 | Submission Open

Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Treatment for Bacterial Infections: 2nd Edition

edited by Janusz Madaj

submission deadline 31 May 2026 | Viewed by 44 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Mechanisms of Myocardial Disease

edited by

Maicon Landim-Vieira

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: cardiac muscle; calcium; sarcomere; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; mitochondria; calmodulin

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Antimicrobial Resistance Mechanism

edited by

Davide Carcione

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: horizontal gene transfer; efflux pumps; biofilm formation; plasmid-mediated resistance; antibiotic stewardship

(This special issue belongs to the Section Molecular Microbiology)

Cardiometabolic Disease: Molecular Biomarkers and Treatment Strategies

edited by Mehrnaz Abbasi

submission deadline 31 May 2026 | Viewed by 42 | Submission Open

Keywords: cardiometabolic diseases; molecular biomarkers; omics technologies; personalized medicine; early detection; machine learning; disease progression; metabolic pathways; transcriptomics; genomic profiling; bioinformatics; therapeutic targets; metabolic dysregulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Foodomics: Challenges and Opportunities for a Sustainable Future

edited by

Mónica Carrera

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: foodomics; sustainable food systems; omics; food quality; safety and innovation; green and circular technologies; personalized nutrition

(This special issue belongs to the Section Biochemistry)

Post-Translational Modifications Regulating Transcription Factors Activity in Biology and Pathology

edited by

Laura Tosatto

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: transcription factors; transcription regulation; post-translational modification; phase separation; cell signalling; disorder-to-order and order-to-disorder transition; protein– protein interaction; protein– DNA interaction

(This special issue belongs to the Section Biochemistry)

Understanding Reproductive Health and Infertility: Molecular and Genetic Insights: 2nd Edition

edited by

Jan Tesarik

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: sperm quality; oocyte quality; uterine receptivity

(This special issue belongs to the Section Molecular Biology)

Metabolic Dysfunction in Brain Disorders: Molecular Pathways and Therapeutic Approach

edited by

Janusz Błaszczyk

submission deadline 31 May 2026 | Viewed by 39 | Submission Open

Keywords: molecular basis; brain metabolism; brain aging; neurodegenerative disorders; Alzheimer disease; Parkinson disease; mood disorders

(This special issue belongs to the Section Molecular Neurobiology)

DNA, Chromatin and Genome Structure

edited by Myakishev-Rempel Max and

Alexandre Vetcher

submission deadline 31 May 2026 | Viewed by 37 | Submission Open

Keywords: DNA structure and dynamics; non-B DNA structures (G-quadruplexes; Z-DNA); DNA topology; R-loops; RNA-DNA triplexes; extrachromosomal DNA (eccDNA); chromatin conformation (Hi-C; Micro-C; 3C); chromatin compaction; TADs and chromatin loops; three-dimensional genome organization; transcription regulation; gene regulation; DNA replication; DNA repair; transposable elements; chromosomal rearrangements; epigenetics; molecular modeling of DNA; molecular modeling of DNA hydration; molecular modeling of chromatin; telomeres; centromeres; introns; noncoding DNA

(This special issue belongs to the Section Molecular Biology)

Genetics and Molecular Mechanisms of Cancer Immunotherapy Response

edited by

Javier Oliver

submission deadline 31 May 2026 | Viewed by 37 | Submission Open

Keywords: cancer immunotherapy; genetic biomarkers; immunogenomics; immune checkpoint inhibitors; resistance mechanisms; precision oncology; germline variants; molecular response prediction; immune-related adverse events

(This special issue belongs to the Section Molecular Oncology)

Individualised Therapies for Rare Disorders

edited by Paul Gissen

submission deadline 31 May 2026 | Viewed by 36 | Submission Open

Keywords: individualised therapies; personalised medicine; rare diseases; omics; gene therapy; molecular pathways; mechanistic discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Signaling and Stress Adaptation in Plants: 2nd Edition

edited by

Kangdi Hu

submission deadline 31 May 2026 | Viewed by 36 | Submission Open

Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

From Pathogenic Mechanisms to Therapy in Gynecological Diseases

edited by

David B. Alexander

submission deadline 31 May 2026 | Viewed by 35 | Submission Open

Keywords: malignant gynecological diseases; screening for gynecological cancers; benign gynecological conditions; screening for benign gynecological diseases; endometriosis; polycystic ovaries syndrome; ovarian cysts; uterine fibroids; leiomyomas; adenomyosis; pelvic inflammatory disease; vaginitis; vaginal dysbiosis; treatment targets for gynecological diseases

(This special issue belongs to the Section Molecular Oncology)

Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies (2nd Edition)

edited by

Tarek Ali Ahmed Ibrahim Alshaal

submission deadline 31 May 2026 | Viewed by 34 | Submission Open

Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions

(This special issue belongs to the Section Molecular Plant Sciences)

Sphingolipids: Health and Disease

edited by

Paola Giussani

submission deadline 31 May 2026 | Viewed by 32 | Submission Open

Keywords: sphingolipids; ceramide; sphingosine-1-phosphate; complex sphingolipids; gangliosides

(This special issue belongs to the Section Biochemistry)

Advances in Pathogenesis, Biomarkers, and Therapeutic Development in Huntington’s Disease

edited by Jesús Pérez-Pérez

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: Huntington’ s disease; somatic instability; genetic modifiers; HD RNA biology; mutant huntingtin; molecular pathogenesis; biomarkers; neurobiology of chorea; cognition and psychiatric disturbances; HTT-lowering therapies; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Integrative Mechanisms and Translational Outcomes of Excitatory–Inhibitory Neurotransmission Switching in Neuropathic Pain

edited by

Poppy Schoenberg

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: neuropathic pain; excitatory– inhibitory balance (E/I balance); neurotransmission switching; microglia; spinal dorsal horn; circuit remodeling; translational biomarkers; computational modeling; glutamatergic signaling; neuromodulation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Genetics of Arthritis

edited by

Bouchra Edderkaoui

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: arthritis; genetic susceptibility; genome-wide association studies; population genetics; genetic loci; epigenetics; gene-environmental interaction; polygenic risk scores; transcriptomics; single-cell sequencing; genomics; rare variants; polymorphisms; candidate genes; autoimmunity genetics; genetics of cartilage; degeneration; regeneration; and inflammatory pathways; genetic biomarkers; pharmacogenomics; functional genomics; precision medicine/ personalized treatments

(This special issue belongs to the Section Molecular Genetics and Genomics)

Functions and Mechanisms of Hepatic Cancer-Associated Genes and miRNAs

edited by Eleni-Myrto Trifylli

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: microRNAs (miRNAs); hepatocellular carcinoma (HCC); hepatic cancer; extracellular vesicles; noncoding RNAs; circular RNAs (circRNAs); gene regulation; epigenetics; drug resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Discovery of Plant-Derived Compounds and Their Immunomodulatory Applications

edited by

Jun Jiang

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: plant-derived compounds; immunomodulators; phytochemicals; immune signaling; natural products; autoimmune diseases; intestinal flora; in vitro evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Small-Molecule Fluorescent Probes: From Design to Biological Applications

edited by Qinglong Qiao

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: fluorescent probes; fluorescence imaging; biosensors; molecular design; biological applications

(This special issue belongs to the Section Molecular Biophysics)

The Circadian Clock in Aging and Age-Related Diseases

edited by

Gianluigi Mazzoccoli

Tommaso Colangelo

and

Giovanni Damiani

submission deadline 31 May 2026 | Viewed by 29 | Submission Open

Keywords: circadian timing system; molecular clockwork; rhythmicity; biological clock; aging inflammation; metabolism; endoplasmic reticulum stress

(This special issue belongs to the Section Molecular Immunology)

Neurological Mechanisms of Action of Natural Products

edited by Damião Pergentino De Sousa

submission deadline 31 May 2026 | Viewed by 29 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; epilepsy; dementia; pain; essential oils; medicinal plants; alkaloids; flavonoids; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Latest Advances on Natural Bioactive Molecules and Polysaccharides

edited by Loredana Marcolongo

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: natural products; bioactive compounds; polysaccharides; extraction technologies; bioprocesses; value-added products; one-health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetic Variations in Human Diseases: 3rd Edition

edited by

Paweł Niemiec

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: genetic polymorphism; gene– gene interaction; gene– environment interaction; monogenic disorder; mutation phenotype; quantitative trait locus; family-based study; cohort study; association study

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Materials for Next-Generation Energy Storage: Molecular Design, Functional Properties, and Applications

edited by

Carlos Miguel Costa

and

Senentxu Lanceros-Mendez

submission deadline 31 May 2026 | Viewed by 26 | Submission Open

Keywords: energy storage devices; molecular materials; smart functionalities; structure-property relationships; molecular design and engineering; advanced applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Synthesis and Activity Studies of Anticancer Compounds

edited by Agata Pacuła-Miszewska

submission deadline 31 May 2026 | Viewed by 26 | Submission Open

Keywords: anticancer agents; structure-activity relationship; cytotoxicity mechanisms; medicinal chemistry; drug design

(This special issue belongs to the Section Molecular Pharmacology)

Determinants of Chronic Diseases: Cellular Mechanisms and the Role of Natural Compounds

edited by Andrei Lobiuc

submission deadline 31 May 2026 | Viewed by 24 | Submission Open

Keywords: chronic diseases; natural compounds; cellular mechanisms; bioactive molecules; signal transduction; oxidative stress; inflammation; apoptosis; mitochondrial dysfunction; therapeutic targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Curcumin Derivatives and Curcuminoids with Potential Biomedical Applications

edited by

Paola Bonaccorsi

and

Chiara Maria Antonietta Gangemi

submission deadline 31 May 2026 | Viewed by 23 | Submission Open

Keywords: curcumin; curcuminoids; synthesis; biomedicine; bioimaging; supramolecular; sensors; photodynamic therapy; antitumor properties; antiviral properties; antibacterial properties; antioxidant properties

(This special issue belongs to the Section Molecular Pharmacology)

Emerging Trends of Biotechnology in Bioremediation and Biodegradation

edited by

Marta Alejandra Polti

submission deadline 31 May 2026 | Viewed by 22 | Submission Open

Keywords: emerging technologies; biological treatment; environmental sustainability; innovative methodologies; ecosystem restoration

(This special issue belongs to the Section Molecular Biology)

Molecular Strategies for Vital Pulp Therapy and Endodontic Regeneration

edited by

Matthias Widbiller

submission deadline 31 May 2026 | Viewed by 21 | Submission Open

Keywords: endodontics; biomaterials; vital pulp therapy; tissue engineering; regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis of Pathogenic Fungi: The Era of AI and New Technologies

edited by

Paul Wai Kei Tsang

submission deadline 31 May 2026 | Viewed by 21 | Submission Open

Keywords: artificial intelligence; molecular diagnosis and detection; therapeutic targeting; resistance and prediction; host relationships; immunity

(This special issue belongs to the Section Molecular Microbiology)

Bioinformatics Study in Human Diseases: Integration of Omics Data for Personalized Medicine (Third Edition)

edited by

Hung-Yu Lin

submission deadline 31 May 2026 | Viewed by 17 | Submission Open

Keywords: cancers; ageing-related diseases; bioinformatics; multi-omics; pharmacogenetics; deep learning; evolutionary learning; diagnosis; prognosis; companion biomarker; drug screening; mechanism dissection

(This special issue belongs to the Section Molecular Informatics)

The Role of Mitochondria in Renal and Cardiac Diseases

edited by

Ana Karina Aranda-Rivera

submission deadline 31 May 2026 | Viewed by 15 | Submission Open

Keywords: kidney and cardiac diseases; mitochondria; mitochondrial impairment; cardiorenal syndrome; mitochondrial proteins; dynamics; bioenergetics

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Pathology and Treatment of Breast Cancer

edited by

Nabil Ismaili

submission deadline 31 May 2026 | Viewed by 13 | Submission Open

Keywords: breast cancer; molecular pathology; precision medicine; antibody-drug conjugates (ADCs); circulating tumor DNA (ctDNA); targeted therapy; immunotherapy; treatment resistance; oligometastatic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Metabolism in Health and Diseases

edited by

Yongting Luo

and Peng An

submission deadline 31 May 2026 | Viewed by 13 | Submission Open

Keywords: mitochondria metabolism; mitochondrial signaling; mitochondrial homeostasis; health and disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Research on Esophageal Cancer

edited by

Antônio Palumbo Júnior

and Nathalia de Oliveira Meireles Da Costa

submission deadline 31 May 2026 | Viewed by 11 | Submission Open

Keywords: esophageal carcinogenesis; esophageal cancer prevention and diagnosis; molecular profiling of esophageal cancer; microenvironment and metastasis of esophageal cancer; molecular therapy approaches in esophageal cancer

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Development and Inhibition of Oral Biofilms

edited by Arunima Mishra

submission deadline 31 May 2026 | Viewed by 11 | Submission Open

Keywords: oral biofilms; dental plaque; biofilm structure/architecture; oral biofilm management; quorum-sensing inhibitors; anti-microbial peptides; glucosyltransferases; coaggregation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Biology of Gynecologic Health and Disease

edited by Marcin Bobiński

submission deadline 31 May 2026 | Viewed by 7 | Submission Open

Keywords: molecular biomarkers; gynecologic endocrinology; gynecologic oncology; hypothalamic– pituitary– ovarian axis; ovarian reserve and reproductive aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Translational Advances in Melanoma Molecular Research

edited by

Marcela S. Villaverde

submission deadline 31 May 2026 | Viewed by 7 | Submission Open

Keywords: melanoma; molecular targets; resistance mechanism; future advances; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Epilepsy: Molecular Neuropharmacology, Calcium Signalling, Neuroinflammation, and Drug Discovery

edited by Maria F. Cano-Abad

submission deadline 31 May 2026 | Viewed by 6 | Submission Open

Keywords: epilepsy receptor pharmacology; neurotransmitter receptor modulation; calcium signaling and homeostasis; therapeutic targets in epilepsy; GABAergic and glutamatergic systems

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors: 2nd Edition

edited by

Emily Capone

submission deadline 31 May 2026 | Viewed by 5 | Submission Open

Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design

(This special issue belongs to the Section Molecular Oncology)

From ER Stress to Clinical Biomarkers: Integrating Mechanistic Understanding with Diagnostic Innovation

edited by

Maria Francesca Armentano

and

Rocchina Miglionico

submission deadline 31 May 2026 | Viewed by 4 | Submission Open

Keywords: unfolded protein response (UPR); circulating biomarkers; extracellular vesicles; translational laboratory medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Polymer Composites: Macromolecular Structure and Application

edited by

Donatella Duraccio

submission deadline 31 May 2026 | Viewed by 2 | Submission Open

Keywords: polymer composites; macromolecular structure; reinforcement strategies; structure– property relationships; sustainable materials

(This special issue belongs to the Section Macromolecules)

Drosophila: A Versatile Model in Biology and Medicine—3rd Edition

edited by

Roberto Piergentili

submission deadline 31 May 2026 | Viewed by 1 | Submission Open

Keywords: model organism; human disease; inherited disease; cancer; neurodegeneration; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Machine Learning–Based Perspectives in Plant Biology

edited by Silas Pessini Rodrigues

submission deadline 31 May 2026 | Submission Open

Keywords: machine learning; artificial intelligence; plant molecular biology; multi-omics integration; feature selection; gene prioritization; plant stress responses; high-throughput phenotyping; crop improvement; biotechnology

(This special issue belongs to the Section Molecular Informatics)

Long-COVID and Its Complications

edited by

Alexey Sarapultsev

submission deadline 20 Jun 2026 | 10 articles | Viewed by 38987 | Submission Open

Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications

edited by

Kota V. Ramana

submission deadline 20 Jun 2026 | 10 articles | Viewed by 23455 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Transporters in Health and Disease

edited by

Giuliano Ciarimboli

submission deadline 20 Jun 2026 | 7 articles | Viewed by 16043 | Submission Open

Keywords: transporters; disease; regulation; drugs; toxicity; signaling

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2951-3000 on page 60 of 68.

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