Discovery of Plant-Derived Compounds and Their Immunomodulatory Applications

Dear Colleagues,

The immune system plays a critical role in maintaining physiological homeostasis, and its dysregulation is implicated in diverse pathologies, including chronic inflammation, autoimmune diseases, and cancer. While synthetic immunomodulators exist, their utility is often limited by side effects or narrow targeting, driving the search for safer, multi-target alternatives derived from natural sources. Plant-derived compounds, such as flavonoids, alkaloids, terpenoids, and polysaccharides, exhibit broad immunomodulatory potential by influencing key immune cells (e.g., macrophages, dendritic cells, T cells) and signaling pathways including NF-κB and MAPK. This Special Issue, titled "Discovery of Plant-Derived Compounds and Their Immunomodulatory Applications," invites original research and reviews that explore the identification, mechanistic action, and therapeutic prospects of phytochemicals in modulating immune responses. Topics of interest include the role of plant metabolites in anticancer immunity, autoimmune regulation, vaccine adjuvants, and novel delivery systems to enhance bioavailability. By integrating traditional knowledge with modern molecular techniques, this Special Issue will advance the development of plant-based immunotherapeutics and foster interdisciplinary collaboration.

Dr. Jun Jiang
Guest Editor

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