Advanced Research on Esophageal Cancer

Dear Colleagues,

Esophageal cancer (EC) is primarily represented by the esophageal squamous carcinoma (ESCC) and esophageal adenocarcinoma (EAC) subtypes, which differ in many aspects, including geographic location, etiological factors, and the molecular alterations that govern the development of these two EC subtypes. Moreover, esophageal cancer is already known as a highly incident and lethal neoplasia, in which late detection and poor prognosis are intimately associated with the poor development of therapeutic approaches for this cancer type. In this way, EC still remains poorly impacted by new therapeutic options, a fact that could be associated with low biological knowledge of this tumor. Therefore, the discovery and identification of new molecular targets, as well as the understanding of their role in development and evolution of EC, may comprise crucial stages in increase understanding of this field. In this sense, despite the scientific revolution experienced during recent years, EC still presents a disappointing prognosis. Thus, due to the notorious molecular heterogeneity characterizing EC’s natural history, for this Special Issue, we invite you to contribute recent discoveries in the field that could be potentially associated not only with EC detection and prognosis but also with the mechanisms involved in the development and treatment of this disease.

Dr. Antônio Palumbo Júnior
Dr. Nathalia de Oliveira Meireles Da Costa
Guest Editors

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