Mitochondrial Metabolism in Health and Diseases

Dear Colleagues, 

Mitochondrial metabolism serves as a fundamental pillar of cellular life, underpinning a range of critical processes such as bioenergetics, cellular metabolism, fatty acid β-oxidation, apoptosis, reactive oxygen species (ROS) signaling, and redox homeostasis. Its balance is intimately linked to mitochondrial dynamics—including fusion and fission—as well as biogenesis, oxidative phosphorylation, mitophagy, and DNA integrity. Disruptions to mitochondrial metabolism, whether triggered by aberrant signaling or nutrient imbalances, often contribute to mitochondrial-related disorders through diverse cellular and molecular mechanisms. Such dysfunction is associated with various pathological states and a spectrum of diseases. Overall, mitochondrial metabolism plays a pivotal role in human health and disease, influencing the pathogenesis of cancer, metabolic disorders, cardiovascular conditions, aging, and neurodegenerative diseases.

This Special Issue will advance our understanding of mitochondrial metabolism, offering theoretical and molecular insights that may inform novel strategies for promoting human health and treating related diseases. We welcome the submission of well-designed research articles, reviews, and meta-analyses on these topics.

Prof. Dr. Yongting Luo
Dr. Peng An
Guest Editors

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