The Circadian Clock in Aging and Age-Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 11
Special Issue Editors
2. Adjunct Professor of Chronobiology, University of Foggia, Foggia, Italy
Interests: chronobiology; chronogenetics; chronomedicine; metabolism; autophagy; oxidative stress; inflammation; aging
Special Issues, Collections and Topics in MDPI journals
2. Cancer Cell Signaling Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Interests: molecular oncology; cancer biomarkers; microRNA; extracellular vesicles; chronobiology
Special Issues, Collections and Topics in MDPI journals
Interests: systemic inflammation; dermatoepidemiology; multi-omics integration; machine learning; artificial intelligence; chronobiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is a complex physiological phenomenon that happens inevitably and slowly. Across all life forms, this process is associated with the deterioration of homeostasis caused by the gradual decline in the ability of tissues and organs to repair and regenerate, with diminished physiological reserves in reaction to external and internal challenges. Aging is intricately linked to oxidative stress and encompasses immunosenescence and tissue damage or metabolic disruptions that initiate inflammation and inflammasome activation. One major change associated with aging is the disruption of the immune response, which leads to persistent mild, widespread inflammation, referred to as "inflammaging". Genetic and epigenetic alterations, along with environmental influences, enhance and/or regulate the processes of aging at the molecular, cellular, tissue, and system levels. The majority of these mechanisms are defined through temporal patterns of change influenced by the circadian clock.
In this Special Issue of International Journal of Molecular Sciences, we will bring together timely articles focused on the numerous and various aspects of scientific research on the participation of age-related processes alongside chronic low-level systemic inflammation intermingled with the operation of the molecular clockwork, and the circadian pathways governing this complex interplay.
This Special Issue welcomes the submission of original research articles and reviews.
Prof. Dr. Gianluigi Mazzoccoli
Dr. Tommaso Colangelo
Dr. Giovanni Damiani
Guest Editors
Manuscript Submission Information
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Keywords
- circadian timing system
- molecular clockwork
- rhythmicity
- biological clock
- aging inflammation
- metabolism
- endoplasmic reticulum stress
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