Translational Advances in Melanoma Molecular Research

Dear Colleagues,

Melanoma remains one of the most aggressive forms of skin cancer, characterized by its high metastatic potential and resistance to conventional therapies. Over the past decade, remarkable progress in genomics, transcriptomics, and molecular pathology has substantially deepened our understanding of the biological mechanisms that drive melanoma initiation, progression, and therapeutic response. Mutations in key oncogenic pathways, epigenetic alterations, tumor–microenvironment interactions, and mechanisms of immune evasion have emerged as central components of melanoma behavior.

Despite these advances, a significant proportion of patients still develop resistance or derive only limited clinical benefit. This underscores the need for continued research into the molecular foundations of melanoma, with the goal of identifying new biomarkers, improving prognostic tools, and expanding therapeutic options.

We are pleased to invite you to contribute to the Special Issue “Translational Advances in Melanoma Molecular Research.”

This Issue aims to bring together cutting-edge studies on current advances of melanoma molecular reasearch, from basic mechanistic discoveries to translational approaches with potential clinical impact. By highlighting current advances and emerging trends, the collection aims to foster a deeper understanding of melanoma biology and inspire innovative strategies to improve patient outcomes.

Research areas may include (but are not limited to) epigenetics, immune-evasion mechanisms, and metabolic reprogramming. Studies focused on the mechanisms underlying therapeutic response or resistance are particularly relevant. Contributions exploring translational approaches and novel therapeutic targets are also highly valued. Together, these areas aim to provide an integrative overview of current molecular research in melanoma and to inspire future advances in the field.

I look forward to receiving your contributions.

Dr. Marcela S. Villaverde
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.