Molecular Research in Gynecological Cancers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 May 2026
Special Issue Editor
Interests: nanoparticles; carcinogenic potential; lactoferrin; caner therapy
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Special Issue Information
Dear Colleagues,
The Centers for Disease Control and Prevention recognizes five main types of gynecologic cancers: cervical cancer, ovarian cancer, uterine cancer, vaginal cancer, and vulvar cancer. The Global Cancer Observatory reports that in 2022 gynecological cancers were the leading cause of cancer-related death in women. A screening test that can detect gynecological cancers in their early stages exists only for cervical cancer. However, as noted by Lizarazo-Taborda et al. (Molecular Research in Gynecological Diseases—2nd Edition) a significant percentage of women do not consent to cervical sampling, which is one reason that cervical cancer is the leading cause of gynecological cancer mortality. Consequently, non-cervical screening tests for cervical cancer and screening tests for the other types of gynecological cancers are a high priority.
In addition, it is well known that benign gynecological diseases affect a huge number of women. The Global Burden of Disease Study, 2021, reported the occurrence of gynecological disease in 2,170,136,352 women 15-49 years old (see Table 1 in Gao et al., PMC12010537). In addition, many women suffer gynecological pain, but since the pain is not debilitating, they do not seek medical treatment. Consequently, the actual prevalence of gynecological disease is very likely to be much higher than reported values. Importantly, gynecological pain receives low treatment priority. In June 2022, The Guardian published "Dismissal of women’s health problems as ‘benign’ leading to soaring NHS lists", and in 2024, the BBC published "Gynaecology waiting lists double, leaving women in pain", and in 2025, the BBC published " 'Unfair' NHS wait lists revealed in official report". While benign gynecological diseases are generally not fatal, they can have a significantly adverse effect on the quality of life of hundreds of millions of women.
The International Journal of Molecular Sciences introduces this Special Issue to create a collection of papers regarding specific topics and to build a community of authors and readers, enabling the discussion of the latest research and the development of new ideas and research directions. This Special Issue is soliciting review articles, original research articles, and short communications regarding the molecular aspects of gynecological diseases. These include identifying markers that can be used in the screening and diagnosis of relevant gynecological diseases, investigating DNA mutations and cellular signaling pathways that lead to the development of the disease, investigating the involvement of the microbiota in various gynecological diseases, and identifying targets that can be used in the treatment of the disease, including potential targets for CRISPR-mediated therapies.
Dr. David B. Alexander
Guest Editor
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Keywords
- malignant gynecological diseases
- screening for gynecological cancers
- benign gynecological conditions
- screening for benign gynecological diseases
- endometriosis
- polycystic ovaries syndrome
- ovarian cysts
- uterine fibroids
- leiomyomas
- adenomyosis
- pelvic inflammatory disease
- vaginitis
- vaginal dysbiosis
- treatment targets for gynecological diseases
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