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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Pathology and Imaging for Precision Diagnosis and Treatment of Tumors

edited by

Maurizio Martini

submission deadline 28 Feb 2026 | 6 articles | Viewed by 6283 | Submission Open

Keywords: molecular pathology; molecular imaging; precision oncology; biomarkers; digital pathology; artificial intelligence

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Computed Tomography Imaging in Medical Diagnosis, 2nd Edition

edited by

Fabio Sandomenico

submission deadline 28 Feb 2026 | 4 articles | Viewed by 6054 | Submission Open

Keywords: computed tomography; medical diagnosis; imaging; internal organs; bones; soft tissue; blood vessels

(This special issue belongs to the Section Medical Imaging and Theranostics)

Explainable Machine Learning in Clinical Diagnostics

edited by

Kai-Chih Pai

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5546 | Submission Open

Keywords: interpretable machine learning (IML); explainable machine learning; clinical medicine; knowledge integration; global/local explanations

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

AI in Dermatology

edited by Jonathan Shapiro

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5226 | Submission Open

Keywords: teledermatology; artificial intelligence; AI algorithms; natural language processing

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Technological Advances in Oral and Maxillofacial Surgery for Diagnosis

edited by

Maria Giulia Cristofaro

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5085 | Submission Open

Keywords: oral and maxillofacial surgery; oral cancers; maxillofacial trauma; surgical and informatics technology; intraoperative navigation; robotic surgery; oral and maxillofacial surgery reconstruction; nanotechnologies; DNA sequencing

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Gynecological Oncology: Advanced Diagnosis and Management in 2025

edited by

Zoard T. Krasznai

and

Rudolf Lampé

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4534 | Submission Open

Keywords: gynecology; oncology; endometrial cancer; ovarian cancer; cervical cancer; diagnosis; staging; surgical methods; standardization of surgery; treatment; innovation; precision medicine; artificial intelligence; machine learning

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Clinical Diagnosis and Management in Anesthesia and Pain Medicine

edited by Jamal Hasoon

submission deadline 28 Feb 2026 | 4 articles | Viewed by 4405 | Submission Open

Keywords: anesthesia and pain medicine; interventional pain management; regional anesthesia; neuromodulation; treatment outcomes; clinical practice patterns; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advancements in the Diagnosis and Management of Liver Disease and Liver Transplantation

edited by Ioana Gabriela Lupescu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4389 | Submission Open

Keywords: focal and diffuse liver pathology; liver transplantation; MPMRI; MDCT; advanced imaging techniques; specific liver contrast material; imaging biomarkers; interventional radiology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Current Perspectives and Gaps in the Diagnosis and Management of Rheumatic Diseases

edited by Vikas Majithia

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4310 | Submission Open

Keywords: rheumatology; rheumatic diseases; inflammatory connective tissue diseases; rheumatoid arthritis; systemic lupus erythematosus; vasculitis; spondyloarthritis; scleroderma; osteoarthritis; current perspective; diagnosis; treatment; management

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances and Approaches in Managing Neurological Disorders: Multi-Omics and P4 Medicine

edited by

Shashanka Ashili

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4075 | Submission Open

Keywords: multi-omics; neurological disorders; P4 medicine; Appomics; neurodegenerative disorders; neurodevelopmental disorders; personalized medicine; bioinformatics; aging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Next-Generation Diagnostic Strategies: Bridging Health Sciences and Laboratory Medicine

edited by

Syed M. Shahid

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3957 | Submission Open

Keywords: diabetes mellitus; clinical diagnostics; biomarkers; prevision medicine; glycemic control; digital health

(This special issue belongs to the Section Clinical Laboratory Medicine)

Clinical Diagnosis and Management in Pediatric Surgery

edited by Ioannis A. Valioulis

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3937 | Submission Open

Keywords: pediatric surgery; neonatal surgery; pediatric urology; pediatric oncology; laparoscopy in children; robotic surgery for children; organ transplantation; diagnostic biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Imaging of the Future: From the Standardisation of Diagnostic Processes to Artificial Intelligence

edited by

Emanuele David

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3839 | Submission Open

Keywords: artificial intellicence; technologies; ultrasound; MRI; CT; angiography; mammography

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Thyroid Cancer: Types, Symptoms, Diagnosis and Management

edited by

Mara Carsote

, Mihai-Lucian Ciobica and

Claudiu Nistor

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3738 | Submission Open

Keywords: thyroid neoplasia; thyroiditis; imaging; functional imaging; thyroidectomy; tumor markers; histological exam; molecular findings; pediatric population; pregnancy and thyroid conditions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Pathophysiologic Mechanisms, Diagnosis and Management of Venous Thromboembolism

edited by Emanuele Valeriani

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3676 | Submission Open

Keywords: anticoagulants; deep vein thrombosis; diagnosis; pathophysiology; pulmonary embolism; venous thrombosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnostic Insights for Skin Melanoma

edited by

Luca Roncati

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3140 | Submission Open

Keywords: skin melanoma; tissue biopsy; histopathological examination; immunohistochemistry; dermatoscopy; reflectance confocal microscopy; modern artificial intelligence; imaging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Alzheimer's Disease Diagnosis Based on Deep Learning

edited by Anees Abrol

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3101 | Submission Open

Keywords: Alzheimer's disease (AD); deep learning; MRI; demographic information; disease probability map; convolutional neural network (CNN)

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Innovative Diagnostic Approaches in Retinal Diseases

edited by

Benedetto Falsini

and Andrea Cusumano

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2770 | Submission Open

Keywords: retinal diseases; electrophysiology; imaging; optical coherence tomography

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Imaging in Bone and Soft-Tissue Sarcomas: Practice, Education, and Innovation—2nd Edition

edited by

Paolo Spinnato

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2594 | Submission Open

Keywords: soft-tissue sarcomas; bone sarcomas; imaging; MRI; CT

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis, Treatment, and Management of Hair Disorders

edited by Neil Jairath and

Vignesh Ramachandran

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2466 | Submission Open

Keywords: hair loss; alopecia; management; cicatricial; diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Recent Advances in Endocrinology Pathology

edited by

Mara Carsote

Ana Valea

and

Claudiu Nistor

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2081 | Submission Open

Keywords: histological classification and reporting; cytological analysis; fine-needle aspiration; molecular markers; immunohistochemistry; hormone; dynamic hormonal testing; endocrine tumors

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

New Trends in Cardiovascular Imaging: 2nd Edition

edited by

Hans-Christoph Becker

submission deadline 28 Feb 2026 | 3 articles | Viewed by 1975 | Submission Open

Keywords: cardiac CT; cardiac MRI; hybrid and multimodality imaging; artificial intelligence and machine learning; coronary artery disease; myocardial tissue characterization; congenital heart disease

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Management in Cardiac Intensive Care Medicine

edited by

Elad Asher

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1866 | Submission Open

Keywords: cardiac intensive care; cardiogenic shock; acute heart failure; hemodynamic monitoring; mechanical circulatory support; post-cardiac arrest care; critical care cardiology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Medical Microwave Radiometry for R&D and Practical Applications in 2025

edited by

Igor Goryanin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1805 | Submission Open

Keywords: microwave radiometry; core body temperature; breast cancer detection; artificial intelligence; COVID-19 pneumonia; vulnerable plaque; carotid; hypothermia; hyperthermia; ischemic stroke; traumatic brain injury; rheumatoid arthritis; diabetic foot; brown adipose tissue activity; vesicoureteral reflux

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Advances in Diagnosis and Management of Skin Diseases

edited by

Montserrat Fernández-Guarino

submission deadline 28 Feb 2026 | 4 articles | Viewed by 1797 | Submission Open

Keywords: dermatology; skin disease; molecular diagnostics; laboratory test; assessment of therapies

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Application of Neural Networks in Medical Diagnosis

edited by

Hamid Reza Marateb

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1785 | Submission Open

Keywords: neural networks in diagnostics; medical imaging analysis; deep learning in healthcare; predictive modeling for disease detection; clinical decision support systems; interpretability and explainability in AI; biomedical data processing; personalized medicine applications

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Recent Advances in Biomarkers for Cardiovascular Disease

edited by

Manuela Ciocoiu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1665 | Submission Open

Keywords: cardiovascular risk factors; hypertension; dyslipidemia; overweight; obesity; diabetes mellitus; metabolic syndrome; atherosclerosis; physical inactivity; biomarkers; cardiovascular disease

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Ultrasound Elastography in Musculoskeletal Disorders: From Bench to Bedside

edited by Yoshiki Yamakoshi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1579 | Submission Open

Keywords: ultrasound elastography; shear wave elastography; musculoskeletal ultrasound; tissue elasticity; tendon and ligament imaging; myofascial pain syndrome; sports medicine; rehabilitation; diagnostic imaging; muscle stiffness

(This special issue belongs to the Section Medical Imaging and Theranostics)

Subjective Experiences of Decline and Dementia Risk: Cognitive, Functional, and Emotional Predictors of Cognitive Decline

edited by Katya Numbers

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1502 | Submission Open

Keywords: subjective cognitive decline (SCD); dementia risk; cognitive complaints; functional decline; emotional well-being; early diagnosis and intervention

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Application of Radiomics in Clinical Diagnosis

edited by

Alfonso Reginelli

and

Vittorio Patanè

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1434 | Submission Open

Keywords: radiomics; clinical diagnosis; medical imaging; quantitative imaging biomarkers; artificial intelligence; machine learning; image analysis; precision medicine; computer-aided diagnosis; multimodal imaging; feature extraction; predictive modeling; diagnostic imaging; integrative diagnostics; imaging biomarkers

(This special issue belongs to the Section Medical Imaging and Theranostics)

Clinical Anatomy and Diagnosis of Peripheral Nervous System—2nd Edition

edited by

Alexandra Diana Vrapciu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1425 | Submission Open

Keywords: anatomy; peripheral nervous system; imaging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Advances in Maternal–Fetal Medicine

edited by Roxana Elena Bohiltea

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1309 | Submission Open

Keywords: maternal– fetal medicine; pregnancy; prenatal care

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Prenatal Diagnosis: From Morphological Evaluation to Genetic Testing

edited by

Antonio Pizzuti

and

Gioia Mastromoro

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1037 | Submission Open

Keywords: prenatal diagnosis; fetal ultrasound (US); fetal magnetic resonance imaging (MRI); chromosomal microarray analysis; next-generation sequencing; exome sequencing; genome sequencing; non-invasive prenatal screening; non-invasive prenatal diagnosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Clinical Impacts and Value of Anatomy, 2nd Edition

edited by

Maria Piagkou

submission deadline 28 Feb 2026 | 1 articles | Viewed by 843 | Submission Open

Keywords: musculoskeletal anatomy; clinical anatomy; surgical anatomy; vascular; nervous system; anatomical variations

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances and Challenges in the Diagnosis and Treatment of Rheumatic Diseases

edited by

Anastas Batalov

Mariela Geneva-Popova

and Zgurov Batalov

submission deadline 28 Feb 2026 | 1 articles | Viewed by 566 | Submission Open

Keywords: rheumatology ; rheumatic diseases ; musculoskeletal ultrasound ; clinical diagnostics ; biomarkers ; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Computer-Aided Diagnosis and Prognosis of Diseases 2025

edited by

Kenji Suzuki

submission deadline 28 Feb 2026 | Viewed by 489 | Submission Open

Keywords: computer-aided detection and diagnosis; early detection; diagnosis; characterization and intervention; advanced imaging; quantitative imaging; image-guided therapy; personalized medicine; precision medicine; biomarkers; machine/deep learning; radiogenomics; radiomics; computational/artificial intelligence; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Application of Cone Beam Computed Tomography for Maxillofacial Diseases, Third Edition

edited by

Yiu Yan Leung

submission deadline 28 Feb 2026 | 1 articles | Viewed by 489 | Submission Open

Keywords: cone-beam computed tomography; imaging; radiology; oral and maxillofacial surgery; dentistry; diagnosis; risk management; 3D printing; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Musculoskeletal Radiology

edited by

Jernej Vidmar

submission deadline 28 Feb 2026 | Viewed by 365 | Submission Open

Keywords: musculoskeletal radiology; high-resolution MRI; ultrasound-guided interventions; artificial intelligence in imaging; CT imaging techniques

(This special issue belongs to the Section Medical Imaging and Theranostics)

Imaging in Cardiomyopathy

edited by

Sophie Mavrogeni

submission deadline 28 Feb 2026 | Viewed by 320 | Submission Open

Keywords: cardiomyopathy; imaging technologies; cardiac MRI; echocardiography; CT; tissue characterization; myocardial fibrosis; disease progression; diagnosis; management

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnostics in Maxillofacial Oncology and Trauma

edited by

Ioanna Kalaitsidou

and

Benoît Schaller

submission deadline 28 Feb 2026 | 1 articles | Viewed by 308 | Submission Open

Keywords: maxillofacial diagnostics; craniofacial trauma; oral and maxillofacial oncology; artificial intelligence in imaging; photon-counting CT (PCCT); molecular biomarkers; histopathology; radiomics; multimodal imaging; preoperative planning

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Pathology for Forensic Diagnosis

edited by

Cristina Mondello

and Vincenzo Cianci

submission deadline 28 Feb 2026 | 1 articles | Viewed by 288 | Submission Open

Keywords: forensic pathology; forensic medicine; forensic radiology; forensic genetics; forensic toxicology; postmortem interval; forensic odontology; forensic entomology; forensic anthropology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Current Diagnosis and Management of Oral Cancer: Challenges, Advances, and Multidisciplinary Integration

edited by Eleni A. Georgakopoulou

submission deadline 28 Feb 2026 | Viewed by 281 | Submission Open

Keywords: oral cancer; early diagnosis; oral squamous cell carcinoma; artificial intelligence; oral potentially malignant disorders; multidisciplinary management; tumor board; oral pathology; misinformation; dental screening

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovative Advances in Diagnosis Through Artificial Intelligence

edited by Jorge Mateo Sotos

submission deadline 28 Feb 2026 | Viewed by 272 | Submission Open

Keywords: artificial intelligence; medical diagnostics; predictive analytics; machine learning; deep learning; digital pathology; early disease detection; personalized medicine; smart healthcare

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

The Role of Biomarkers in Alzheimer's Disease

edited by

Ram Sagar

submission deadline 28 Feb 2026 | Viewed by 257 | Submission Open

Keywords: Alzheimer's disease; biomarkers; cerebrospinal fluid proteins; MRI; amyloid imaging; early diagnosis

(This special issue belongs to the Section Clinical Laboratory Medicine)

Artificial Intelligence and Big Data in Digestive Healthcare

edited by Hélder Cardoso and

Miguel Mascarenhas

submission deadline 28 Feb 2026 | Viewed by 246 | Submission Open

Keywords: artificial intelligence; big data; digestive system diseases; digestive system neoplasms; electronic health records; endoscopy; precision medicine

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Current Trends and Future Directions in Radiotheragnostic Research: A Special Issue in Collaboration with ISRT 2025

edited by

Kalevi Kairemo

submission deadline 28 Feb 2026 | Viewed by 235 | Submission Open

Keywords: precision oncology; oncology; positron emission tomography; radionuclide therapy; targeted therapy; targeted alpha therapy; PSMA; prostate cancer; neuroendocrine neoplasms; somatostatin analogs; daughter radionuclides; dosimetry; small-scale/micro-dosimetry; radiobiology; target chemistry

(This special issue belongs to the Section Medical Imaging and Theranostics)

Applications of Radiomics and Imaging in Oncology and Cardiovascular Diseases

edited by

Dania Cioni

submission deadline 28 Feb 2026 | Viewed by 214 | Submission Open

Keywords: oncologic imaging; cardiovascular imaging; radiomics; artificial intelligence; machine learning; deep learning; magnetic resonance imaging; computed tomography; nuclear medicine; diagnosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnostic Imaging in Acute Respiratory Distress Syndrome

edited by

Denise Battaglini

submission deadline 28 Feb 2026 | Viewed by 196 | Submission Open

Keywords: acute respiratory distress syndrome (ARDS); computed tomography (CT); lung ultrasound (LUS); electrical impedance tomography (EIT); positron emission tomography (PET); imaging biomarkers; quantitative imaging analysis; multimodal imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Pathology and Molecular Diagnosis of Vascular Diseases

edited by

Francisco S. Lozano Sánchez

and María Begoña García-Cenador

submission deadline 28 Feb 2026 | Viewed by 193 | Submission Open

Keywords: vascular pathology; molecular diagnostics; precision medicine; biomarkers; atherosclerosis; thrombosis; vascular imaging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Application of Artificial Intelligence in Infectious Disease Diagnosis

edited by