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Diagnostics, Volume 15, Issue 16

August-2 2025 - 135 articles

Cover Story: From Microscopes to Monitors: Unique Opportunities and Challenges in Digital Pathology Implementation in Remote Canadian Regions explores the transformative potential of digital pathology in geographically isolated settings. The authors present a case study from Timmins, a city in Northern Ontario, detailing how telepathology, infrastructure assessment, and tailored workflows can enhance diagnostic access, efficiency, and quality. They report notable benefits; reduced travel and courier expenses, faster turnaround, and improved patient care, but also acknowledge challenges such as limited connectivity, technical readiness, workforce adaptation, and costs. This work offers valuable insights into deploying digital pathology to bridge equity gaps in rural healthcare. View this paper
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Articles (135)

  • Article
  • Open Access
863 Views
16 Pages

AI in Fracture Detection: A Cross-Disciplinary Analysis of Physician Acceptance Using the UTAUT Model

  • Martin Breitwieser,
  • Stephan Zirknitzer,
  • Karolina Poslusny,
  • Thomas Freude,
  • Julia Scholsching,
  • Karl Bodenschatz,
  • Anton Wagner,
  • Klaus Hergan,
  • Matthias Schaffert and
  • Roman Metzger
  • + 1 author

21 August 2025

Background/Objectives: Artificial intelligence (AI) tools for fracture detection in radiographs are increasingly approved for clinical use but remain underutilized. Understanding physician attitudes before implementation is essential for successful i...

  • Communication
  • Open Access
552 Views
7 Pages

Exploring Laser-Induced Plasma Spectroscopy for Skin Cancer Patients: A Preliminary Study

  • Dimitrios Sgouros,
  • Emmanouil Karampinis,
  • Melpomeni Theofili,
  • Georgia Pappa,
  • Panagiotis Theofilis,
  • Sofia Theotokoglou,
  • Anna Syrmali and
  • Alexander Katoulis

21 August 2025

Skin cancer is the most frequently diagnosed form of cancer worldwide. Diagnostic uncertainty can arise when macroscopic or dermoscopic evaluations do not clearly differentiate between benign and malignant lesions. Laser-induced plasma spectroscopy (...

  • Article
  • Open Access
989 Views
13 Pages

Genotype Frequency of HLA-B*58:01 and Its Association with Paraclinical Characteristics and PSORS1C1 rs9263726 in Gout Patients

  • Hien Thu Nguyen,
  • Ha Thi Bui,
  • Yen Thi Thu Hoang,
  • My Ha Hoang,
  • Manh Duc Ngo,
  • Mai Hoang Nguyen,
  • Thuy Thi Thanh Nguyen,
  • Nhuan Tien Ngo and
  • Quang Viet Nguyen

21 August 2025

Background/Objectives: The HLA-B*58:01 allele is strongly linked to severe cutaneous adverse reactions (SCARs) during allopurinol treatment, and it has been associated with the A allele of PSORS1C1 rs9263726 (G>A). Paraclinical characteristics of...

  • Article
  • Open Access
1 Citations
779 Views
15 Pages

The Utility of Intravoxel Incoherent Motion Metrics in Assessing Disability in Relapsing–Remitting Multiple Sclerosis

  • Othman I. Alomair,
  • Sami A. Alghamdi,
  • Abdullah H. Abujamea,
  • Salman Aljarallah,
  • Nuha M. Alkhawajah,
  • Mohammed S. Alshuhri,
  • Yazeed I. Alashban and
  • Nyoman D. Kurniawan

21 August 2025

Background/Objectives: Quantitative intravoxel incoherent motion (IVIM) imaging, incorporating both diffusion- and perfusion-derived metrics, offers a promising non-invasive approach for assessing tissue microstructure and clinical disability in mult...

  • Article
  • Open Access
992 Views
13 Pages

Quantifying “Medical Renal Disease”: A Pediatric Pilot Study Using Ultrasound Radiomics for Differentiating Acute Kidney Injury and Chronic Kidney Disease

  • Laura De Leon-Benedetti,
  • Laith R. Sultan,
  • Hansel J. Otero,
  • Tatiana Morales-Tisnés,
  • Joya Sims,
  • Kate Fitzpatrick,
  • Julie C. Fitzgerald,
  • Susan Furth,
  • Benjamin L. Laskin and
  • Bernarda Viteri

21 August 2025

Background: Differentiating acute kidney injury (AKI) from chronic kidney disease (CKD) in children remains a critical unmet need due to the limitations of current clinical and biochemical markers. Conventional ultrasound lacks the sensitivity to dis...

  • Article
  • Open Access
1,400 Views
16 Pages

Association of TCF7L2 rs7903146 (C/T) Polymorphism with Type 2 Diabetes Mellitus in a Chinese Population: Clinical Characteristics and Ethnic Context

  • Yung-Chuan Lu,
  • Teng-Hung Yu,
  • Chin-Feng Hsuan,
  • Chia-Chang Hsu,
  • Wei-Chin Hung,
  • Chao-Ping Wang,
  • Wei-Hua Tang,
  • Min-Chih Cheng,
  • Fu-Mei Chung and
  • Yau-Jiunn Lee
  • + 1 author

21 August 2025

Background/Objectives: The transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism has been strongly associated with type 2 diabetes mellitus (T2DM) in various populations; however, its impact on different ethnic groups is not fully understood....

  • Systematic Review
  • Open Access
1,382 Views
23 Pages

21 August 2025

Background: Obstructive sleep apnea (OSA) is one of the most prevalent yet underdiagnosed sleep disorders. We evaluated the diagnostic accuracy of radar-based systems and ranked frequency bands for the non-contact detection of OSA. Methods: A systema...

  • Article
  • Open Access
590 Views
13 Pages

21 August 2025

Background/Objectives: The diagnosis of osteomyelitis is typically based on clinical suspI icion supported by imaging and lab findings. Various nuclear medicine imaging, including bone SPECT/CT, is emerging as an effective tool to guide the diagnosis...

  • Article
  • Open Access
1,050 Views
13 Pages

Thyroid Nodule Characterization: Which Thyroid Imaging Reporting and Data System (TIRADS) Is More Accurate? A Comparison Between Radiologists with Different Experiences and Artificial Intelligence Software

  • Emanuele David,
  • Lorenzo Aliotta,
  • Fabrizio Frezza,
  • Marianna Riccio,
  • Alessandro Cannavale,
  • Patrizia Pacini,
  • Chiara Di Bella,
  • Vincenzo Dolcetti,
  • Elena Seri and
  • Luca Giuliani
  • + 8 authors

21 August 2025

Purpose: This study aimed to compare: the performance of K-TIRADS, EU-TIRADS and ACR TIRADS when used by observers with different levels of experience compared with the gold standard of cytology, and to evaluate the diagnostic performance of CAD (com...

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Diagnostics - ISSN 2075-4418Creative Common CC BY license