Emerging Predictive Biomarkers in Breast Cancer
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 30
Special Issue Editors
Interests: breast cancer; HER2-positive; HER2-negative; ER+; HER2-low; liquid biopsy; immunotherapy; targeted therapy; molecular biology
Special Issue Information
Dear Colleagues,
The treatment landscape of breast cancer has profoundly changed over the last few years with the approval of several new therapeutic options for both early-stage and advanced/metastatic disease. Much progress has been made in discerning the molecular pathology of breast cancer, leading to the identification of different molecular subtypes with distinct clinical–pathological characteristics and therapeutic vulnerabilities. Recently, new novel classes of therapeutic agents have emerged in clinical practice, including immune checkpoint inhibitors and antibody drug conjugates, but there is a lack of reliable predictive biomarkers for these agents, and in some cases, they are still used with a one-size-fits-all approach. Furthermore, the use of circulating biomarkers, namely liquid biopsy, and novel PET tracers in indications is rapidly growing, offering the possibility of further innovating the patient selection process for novel breast cancer therapies.
The aim of this Special Issue is to expand the current knowledge on the molecular, genetic and therapeutic landscape of breast cancer, with a particular focus on novel prognostic and predictive biomarkers that could have an impact on clinical practice. Experimental studies in in vitro and in vivo models, review articles, and clinical studies will be considered.
Dr. Giuseppina Rosaria Rita Ricciardi
Guest Editor
Dr. Maria Vita Sanò
Guest Editor Assistant
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Keywords
- breast cancer
- HER2-positive
- TNBC
- ER+
- HER2-negative
- HER2-low
- PD-L1
- 18F-FES PET
- hormonotherapy
- immunotherapy
- immune checkpoint inhibitors
- liquid biopsy
- circulating tumor cells
- ctDNA
- antibody drug conjugates
- PARP inhibitors
- CDK4/6 inhibitors
- predictive biomarkers
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