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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Musculoskeletal and Neuropathic Pain in COVID-19: Diagnosis and Management Challenge

edited by

César Fernández-de-las-Peñas

and

Lidiane Lima Florencio

submission deadline 31 Aug 2025 | 4 articles | Viewed by 18053 | Submission Open

Keywords: COVID-19; long-COVID; pain; musculoskeletal; neuropathic; sensitization; mechanism

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Image Quality Assessment Methods in Radiography, Computed Tomography and Magnetic Resonance

edited by

Rafał Obuchowicz

Adam Piórkowski

and

Michał Strzelecki

submission deadline 31 Aug 2025 | 8 articles | Viewed by 14928 | Submission Open

Keywords: CR; MRI; CT; image quality; preprocessing and postprocessing; texture analysis; artificial intelligence; quality control

(This special issue belongs to the Section Medical Imaging and Theranostics)

Trends in In Vitro Diagnostics Paving the Way to Next-Generation Healthcare

edited by

Sandeep K. Vashist

submission deadline 31 Aug 2025 | 6 articles | Viewed by 12887 | Submission Open

Keywords: IVDs (in vitro diagnostics); POCT (point-of-care testing); LFA (lateral flow assay); CLIA (clinical laboratory improvement amendments); multiplex assays; PCR; NGS (next-generation sequencing); AI; at-home testing; biomarkers; smart technologies

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Advanced Brain Tumor Imaging

edited by

Giorgio Treglia

and Barbara Muoio

submission deadline 31 Aug 2025 | 6 articles | Viewed by 12641 | Submission Open

Keywords: brain tumors; gliomas; brain metastases; meningioma; neuroimaging; magnetic resonance; PET; MRI

(This special issue belongs to the Section Medical Imaging and Theranostics)

Grand Challenges in the Diagnosis and Management of Cardiovascular and Cerebrovascular Diseases

edited by

Sonu M. M. Bhaskar

submission deadline 31 Aug 2025 | 8 articles | Viewed by 9995 | Submission Open

Keywords: cardiovascular diseases; cerebrovascular diseases; diagnosis; management; imaging; biomarkers; artificial intelligence; therapeutic strategies; pharmacology; surgery; rehabilitation; multidisciplinary care

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Pulmonary and Critical Care Medicine: Diagnosis and Management

edited by

Te-Chun Shen

submission deadline 31 Aug 2025 | 5 articles | Viewed by 9178 | Submission Open

Keywords: COPD; asthma; interstitial lung disease; lung cancer; pneumonia (respiratory infection; pulmonary infection); obstructive sleep apnea; respiratory failure; acute respiratory distress syndrome

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

EEG Analysis in Diagnostics

edited by

Jae-Ho Han

submission deadline 31 Aug 2025 | 7 articles | Viewed by 7468 | Submission Open

Keywords: advanced EEG Techniques; the characterization of EEG signal patterns; the identification of EEG signal abnormalities; functional connectivity analysis in EEG; sleep studies based on EEG; EEG in epilepsy diagnosis and monitoring; neurofeedback and EEG in cognitive enhancement; event-related potentials in clinical EEG; understanding pathophysiology via EEG

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosing Respiratory Diseases and Impaired Gas Exchange Using Machine Learning

edited by

Robert LeMoyne

Jakub Rafl

and Martin Rozanek

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6413 | Submission Open

Keywords: machine learning; user trust with machine learning; deep learning; blood gas sensors; oximeters; wearables; computer automated diagnosis of health status; respiratory diseases; impaired gas exchange; advanced diagnostics

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Information-Driven Computer-Aided Diagnosis and Decision Support System

edited by Wen-Shan Jian and

Shuo-Chen Chien

submission deadline 31 Aug 2025 | 4 articles | Viewed by 5693 | Submission Open

Keywords: computer-aided diagnosis; decision support systems; machine learning in healthcare; artificial intelligence in medicine; medical data analytics; predictive modeling; clinical decision-making; healthcare informatics; diagnostic accuracy; patient outcomes

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Application of Artificial Intelligence in Gastrointestinal Disease

edited by Kai Zhao

submission deadline 31 Aug 2025 | 6 articles | Viewed by 5050 | Submission Open

Keywords: artificial intelligence; machine learning; gastrointestinal disease

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Acute Kidney Injury and Chronic Kidney Disease: From Pathogenesis to Diagnostics

edited by Dimitris Kounatidis and

Natalia G. Vallianou

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4785 | Submission Open

Keywords: acute kidney injury (AKI); chronic kidney disease (CKD); pathogenesis; biomarkers

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Sepsis at the Crossroads: Innovations in Critical Care Management, Diagnostic Tools, and Treatment Paradigms

edited by

Paolo Formenti

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4702 | Submission Open

Keywords: sepsis and clinical recognition; septic shock; SOFA and organ dysfunction; acute kidney injury; renal replacement therapy; new biomarkers; new therapeutic options

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

New Possibilities for Digital Diagnosis and Planning in Dentistry

edited by

Rodolfo Reda

submission deadline 31 Aug 2025 | 4 articles | Viewed by 4382 | Submission Open

Keywords: dental imaging; CBCT; MRI; scan; digital impression; digital plan; digital guide; CAD-CAM; manufacturing

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Management of Dental Medicine and Surgery

edited by

José María Martinez-Gonzalez

submission deadline 31 Aug 2025 | 5 articles | Viewed by 4325 | Submission Open

Keywords: oral surgery; oral medicine; implant dentistry; gerodontology; pharmacological treatments; bone regeneration; oral rehabilitation

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Developments and Future Trends in Thoracic Imaging

edited by Ioana Andreea Gheonea

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3952 | Submission Open

Keywords: X-ray; computed tomography; magnetic resonance imaging; ultra-low-dose CT; photon-counting CT; oncology; artificial intelligence; emergency radiology; thoracic trauma

(This special issue belongs to the Section Medical Imaging and Theranostics)

Applications of Artificial Intelligence in Gastrointestinal Diseases

edited by Dimitra D. Dionysiou and Ioannis Gallos

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3470 | Submission Open

Keywords: gastrointestinal disease; artificial intelligence; biomarkers; screening/diagnosis; personalized medicine; treatment outcome; pathogenesis; risk management

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Future Challenges for Lung and Liver Ultrasound

edited by Chiara De Molo

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3377 | Submission Open

Keywords: lung ultrasound; liver ultrasound; pulmonary ultrasound; diagnosis; sonography

(This special issue belongs to the Section Medical Imaging and Theranostics)

New Advances in Hyperspectral and Multispectral Imaging for Diseases Diagnosis

edited by

Arvind Mukundan

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2851 | Submission Open

Keywords: spectral imaging; hyperspectral imaging (HSI); multispectral imaging (MSI); medical diagnostics; disease detection; clinical applications; imaging technology; early diagnosis; personalized medicine; diagnostic pathways; healthcare innovations; biomedical imaging

(This special issue belongs to the Section Biomedical Optics)

Insights into Pediatric Genetics

edited by

Chunglin Lee

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2626 | Submission Open

Keywords: pediatric genetics; genetic sequencing; rare disorders; genetic diagnosis; precision medicine

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Expanding Horizons in Fascial Diagnostics and Interventions

edited by

Stanley K. H. Lam

and Bradley Dean Fullerton

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2607 | Submission Open

Keywords: ultrasound imaging; fascial pathologies; musculoskeletal function; fascial disorders; ultrasound-guided interventions; musculoskeletal care

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Prognosis of Endometriosis

edited by

Simone Ferrero

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2554 | Submission Open

Keywords: endometriosis; diagnosis; ultrasonography; recurrence; prognosis; symptoms; laparoscopy; biomarkers

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

New Perspectives in Ophthalmic Imaging

edited by

Ratheesh Kumar Meleppat

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2483 | Submission Open

Keywords: optical coherence tomography; retinal imaging; ophthalmic imaging; OCT; diagnosis of eye diseases

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Pathology and Diagnosis of Hematology

edited by

Elizabeth Soilleux

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2243 | Submission Open

Keywords: medical diagnosis; pathology; hematology; leukemia; lymphoma; myeloproliferative disorders; thrombotic microangiopathies

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Symptoms, Diagnosis, Prognosis and Management of Long COVID or Post-COVID Conditions, 2nd Edition

edited by

Tim Duong

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2240 | Submission Open

Keywords: long COVID; SARS-CoV-2; COVID-19 sequela; post-acute sequelae of COVID-19 (PASC); COVID-19 symptoms; multiorgan failure; diabetes; hypertension; shortness of breath; symptoms; diagnosis; prognosis; management

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Hearing Loss and Deafness: Identification, Management, Prevention, and Rehabilitation

edited by Peter J. Kullar and Jameel Muzaffar

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2110 | Submission Open

Keywords: hearing loss; presbycusis; cochlear implants; hearing implants; hearing aids; congenital hearing loss; sudden sensorineural hearing loss

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Immune-Mediated Diseases: Diagnosis and Management

edited by

Marcos López Hoyos

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2109 | Submission Open

Keywords: immune-mediated inflammatory disease; biomarker; companion diagnostics; cytokines; immunoregulation; complement; autoantibodies; innate immunity; adaptive immunity; multiplexing; immunophenotype; mass cytometry; ELISPOT; single-cell RNA

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Neurological Diseases: Biomarkers, Diagnosis and Prognosis

edited by

Theodosis Kalamatianos

submission deadline 31 Aug 2025 | 3 articles | Viewed by 1905 | Submission Open

Keywords: biomarkers; neurological diseases; multiple sclerosis; traumatic brain injury; peripheral neuropathies; COVID-19 neurological-associated damage; diagnosis; prognosis.

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Perspectives in Cardiac Imaging

edited by

George Koulaouzidis

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1819 | Submission Open

Keywords: cardiac imaging; echocardiography; cardiac magnetic resonance imaging; computed tomography

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Liquid Biopsy for the Diagnosis of Breast Cancer

edited by

Chihwan David Cha

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1611 | Submission Open

Keywords: breast cancer; diagnosis; metastasis; ctDNA; liquid biopsy

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Use of Histopathological Image Analysis in Diagnostics

edited by

Elizabeth Soilleux

and Florian Jaeckle

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1444 | Submission Open

Keywords: histopathological; diagnostics; artificial intelligence; algorithms; image analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advancements in the Diagnosis and Treatment of Inflammatory Bowel Diseases

edited by Thomas Klag

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1389 | Submission Open

Keywords: chronic inflammatory bowel diseases (IBD); Crohn's disease (CD); ulcerative colitis (UC); therapy monitoring; extraintestinal manifestations (EIMs); quality of life; artificial intelligence (AI); personalized medicine; personalized medicine; endoscopic advancements

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

New Advances in Cardiovascular Risk Prediction

edited by Ming-Shyan Lin

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1367 | Submission Open

Keywords: cardiovascular diseases; risk prediction; biomarker; machine learning

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Application of Machine Learning in Disease Screening, Diagnosis and Prognosis

edited by Dee Pei

submission deadline 31 Aug 2025 | 3 articles | Viewed by 1265 | Submission Open

Keywords: diagnosis; screening; marker; prognosis; machine learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Multiple Myeloma Imaging in 2025

edited by

Majid Chalian

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1233 | Submission Open

Keywords: PET/CT; MRI; multiple myeloma; diagnosis; multiparametric imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Imaging and Diagnosis in Neurosurgery

edited by Giulio Anichini

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1188 | Submission Open

Keywords: MRI sequences; magnetic electroencephalography; endovascular neurosurgery; fluorescence-guided surgery; spectroscopic technologies (e.g.; Raman; confocal; and hyperspectral); mü ller matrix polarization; intraoperative neuromonitoring; two/three-dimensional endoscopes; exoscopes; artificial intelligence; laboratory diagnostics

(This special issue belongs to the Section Medical Imaging and Theranostics)

Autopsy for Medical Diagnostics: 3rd Edition

edited by

Giulia Ottaviani

and

Simone G. Ramos

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1127 | Submission Open

Keywords: autopsy; post-mortem investigation; cardiovascular pathology; sudden cardiac death; sudden unexpected death; perinatal autopsy; molecular autopsy; virtual autopsy

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Deep Learning in Biomedical Signal Analysis

edited by

Takahiro Emoto

submission deadline 31 Aug 2025 | 2 articles | Viewed by 954 | Submission Open

Keywords: deep learning; biomedical signal processing; pattern recognition; disease diagnosis; feature extraction

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advancing Clinical Diagnosis with Artificial Intelligence: Applications, Challenges, and Future Directions

edited by

Haipeng Liu

Rajesh K. Tripathy

, Shonak Bansal and

Prince Jain

submission deadline 31 Aug 2025 | 1 articles | Viewed by 933 | Submission Open

Keywords: deep learning; artificial intelligence (AI); internet of medical things (IoMT); AI-assisted diagnostics; multimodal clinical data; data-driven healthcare

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Ophthalmology

edited by

Daniela Bacherini

submission deadline 31 Aug 2025 | 1 articles | Viewed by 828 | Submission Open

Keywords: OCT; OCTA; ophthalmology; diagnostics; clinical applications

(This special issue belongs to the Section Biomedical Optics)

Advancements in the Diagnostics and Management of Musculoskeletal Diseases

edited by

Alessandro de Sire

submission deadline 31 Aug 2025 | 2 articles | Viewed by 637 | Submission Open

Keywords: musculoskeletal system; joint; orthopedics; traumatology; rehabilitation; radiology; fracture; muscle; connective tissues; regenerative medicine; tissue engineering

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnosis and Management in Anesthesia and Pain Medicine

edited by Jamal Hasoon

submission deadline 31 Aug 2025 | 1 articles | Viewed by 563 | Submission Open

Keywords: anesthesia and pain medicine; interventional pain management; regional anesthesia; neuromodulation; treatment outcomes; clinical practice patterns; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Future Concepts in Dermatologic Diagnosis

edited by Jonathan Shapiro

submission deadline 31 Aug 2025 | 1 articles | Viewed by 561 | Submission Open

Keywords: skin diseases; skin pathology; molecular profiling; dermatologic diagnostics

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Role of Endoscopic Ultrasound in Clinical Medicine

edited by Germana De Nucci

submission deadline 31 Aug 2025 | 1 articles | Viewed by 559 | Submission Open

Keywords: endoscopic ultrasound (EUS); diagnostic imaging; fine needle aspiration (FNA); contrast-enhanced EUS; elastography techniques

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Diagnosis and Management of Endometrial Cancer

edited by

Fulvio Borella

submission deadline 31 Aug 2025 | Viewed by 487 | Submission Open

Keywords: cancer biology; gynecologic oncology; tumor biomarkers; cancer diagnostics; breast cancer; ovarian cancer; endometrial cancer; vulvar cancer

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Imaging Diagnosis of Dermatology

edited by Linda Tognetti

submission deadline 31 Aug 2025 | Viewed by 369 | Submission Open

Keywords: high-resolution imaging; non-invasive diagnosis; LC-OCT; RCM; OCT; US

(This special issue belongs to the Section Medical Imaging and Theranostics)

Thyroid Cancer: Types, Symptoms, Diagnosis and Management

edited by

Mara Carsote

, Mihai-Lucian Ciobica and

Claudiu Nistor

submission deadline 31 Aug 2025 | Viewed by 356 | Submission Open

Keywords: thyroid neoplasia; thyroiditis; imaging; functional imaging; thyroidectomy; tumor markers; histological exam; molecular findings; pediatric population; pregnancy and thyroid conditions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advancements in Diagnosis of Colorectal Cancer

edited by

Piero Boraschi

submission deadline 31 Aug 2025 | 1 articles | Viewed by 349 | Submission Open

Keywords: colorectal cancer; metastatic disease; colorectal liver metastases; chemotherapy; surgery; therapeutic response assessment; biomarkers; tumor regression grading; computed tomography; MRI; PET; intraoperative ultrasound; multidisciplinary management

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Progression of Ano-Genital Intraepithelial Neoplasia and Tumors in Relation to Biomarkers

edited by Attila Louis Major

submission deadline 31 Aug 2025 | Viewed by 348 | Submission Open

Keywords: intraepithelial neoplasia: cervical; vaginal; vulvar; anal; high-risk human papillomavirus (hr HPV); cancer biomarkers; oncoproteins; P16; Ki-67; immunoscore; epigenetic tests; methylation; prediction of cancer progression; HPV oncogenes E6 and E7; condyloma acuminata; condylomata acuminata gigantea (Buschke– Lö wenstein tumor); molecular; immunologic; and genetic risk factors for persistent and recurrent high-risk HPV infection; anamnestic risk factors for persistent and recurrent high-risk HPV infection; non-HPV-related precancer and cancer of ano-genital organs

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Subjective Experiences of Decline and Dementia Risk: Cognitive, Functional, and Emotional Predictors of Cognitive Decline

edited by Katya Numbers

submission deadline 31 Aug 2025 | 1 articles | Viewed by 339 | Submission Open

Keywords: subjective cognitive decline (SCD); dementia risk; cognitive complaints; functional decline; emotional well-being; early diagnosis and intervention

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Mental Health Diagnosis and Screening, 2nd Edition

edited by Elaine Chapman

submission deadline 31 Aug 2025 | 1 articles | Viewed by 325 | Submission Open

Keywords: mental health; diagnosis; screening; marker; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

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