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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Aspects of CTC Research for Basic Medicine and Clinical Application

edited by Hayao Nakanishi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1060 | Submission Open

Keywords: CTC; metastasis; mobilization; cluster heterogeneity; routine blood test; genetic analysis; CTC organoid

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diabetes Mellitus: Clinical Diagnostics and Management

edited by

Syed M. Shahid

submission deadline 31 Jan 2026 | 1 articles | Viewed by 951 | Submission Open

Keywords: diabetes mellitus; clinical diagnostics; biomarkers; precision medicine; glycemic control; digital health

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Clinical and Interventional Gastroenterology

edited by

Antonio Facciorusso

and

Eyad Gadour

submission deadline 31 Jan 2026 | 1 articles | Viewed by 863 | Submission Open

Keywords: diagnostic endoscopy; AI in gastroenterology; biomarker discovery; capsule endoscopy; confocal laser endomicroscopy; early cancer detection; functional GI disorders; molecular diagnostics; non-invasive imaging; microbiome analysis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Beyond the Tipping Point: Advances in the Diagnosis and Management of Acute-on-Chronic Liver Failure and End-Stage Liver Disease

edited by Jonathan Soldera

submission deadline 31 Jan 2026 | 1 articles | Viewed by 720 | Submission Open

Keywords: liver cirrhosis; hepatorenal syndrome; acute-on-chronic liver failure; liver transplan-tation; biomarkers; diagnostic imaging; artificial intelligence; inflammation media-tors; prognosis; end-stage liver disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advanced Diagnosis and Treatment Plan for Orthodontic and Oro-Facial Rehabilitations—2nd Edition

edited by

Antonino Lo Giudice

submission deadline 31 Jan 2026 | 1 articles | Viewed by 602 | Submission Open

Keywords: CBCT; facial scan; oral imaging; orthodontics; digital dentistry

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnostic and Prognostic Non-Invasive Markers in Bladder Cancer

edited by

Qiang Lv

and Xiao Yang

submission deadline 31 Jan 2026 | 2 articles | Viewed by 556 | Submission Open

Keywords: bladder cancer; diagnostic and prognostic markers; non-invasive; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Endoscopy and Diagnostic Tools in Hepatobiliary and Pancreatic Diseases, Second Edition

edited by

Stefano Francesco Crinò

submission deadline 31 Jan 2026 | 1 articles | Viewed by 453 | Submission Open

Keywords: endoscopic ultrasound; eRCP; radiomics; tissue acquisition; artificial intelligence; magnetic resonance imaging; cholangioscopy; pancreatic cancer; pancreatic cysts; hepatocellular carcinoma; cholangiocarcinoma

(This special issue belongs to the Section Medical Imaging and Theranostics)

Predictive Biomarkers in Oncology

edited by

Jun Zhang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 427 | Submission Open

Keywords: predictive biomarkers; precision oncology; liquid biopsy; treatment response; biomarker validation

(This special issue belongs to the Section Clinical Laboratory Medicine)

Diagnostic, Predictive and Prognostic Biomarkers for Neurodegenerative Diseases

edited by

Ionica Pirici

submission deadline 31 Jan 2026 | 1 articles | Viewed by 424 | Submission Open

Keywords: neurodegenerative diseases; biomarkers; medical imaging; pathology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Breast Diagnostics

edited by Takouhie Catherine Maldjian, Jessica Leung, Mary M. Salvatore and Judy Yee

submission deadline 31 Jan 2026 | 1 articles | Viewed by 358 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; breast imaging; breast cancer; breast cancer prognosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Innovations in Cardiovascular Diagnosis and Risk Stratification

edited by

Sonu M. M. Bhaskar

submission deadline 31 Jan 2026 | Viewed by 312 | Submission Open

Keywords: cardiovascular diseases; cardiac MRI; CT angiography; and molecular imaging; biomarker discovery; artificial intelligence and machine learning; wearable devices and mobile health

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Cardiac Magnetic Resonance Imaging: Current and Future Clinical Applications

edited by

Per Lav Madsen

submission deadline 31 Jan 2026 | Viewed by 208 | Submission Open

Keywords: cardiomyopathy; cardiovascular physiology; ischemic heart disease; metabolic heart disease; stress MRI; heart failure with reduced ejection fraction; heart failure with preserved ejection fraction

(This special issue belongs to the Section Medical Imaging and Theranostics)

Multidisciplinarity in Myeloid Neoplasms: Bridging Diagnostics and Clinical Insights

edited by Alexander Haushofer and Bernhard Strasser

submission deadline 31 Jan 2026 | Viewed by 199 | Submission Open

Keywords: acute myeloid leukemia (AML); myelodysplastic syndromes (MDS); myeloproliferative neoplasms (MPN); MDS/MPN genetic profiling; multidisciplinary collaboration; diagnostic innovation

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostic and Interventional Nephrology

edited by Ammar Almehmi

submission deadline 31 Jan 2026 | Viewed by 190 | Submission Open

Keywords: dialysis access; fistula; graft; stent; peritoneal catheter; drug-coated balloon; EndoAVF; dialysis; vascular access dysfunction; interventional nephrology; diagnostic imaging

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Multimodal Biomarkers, AI, and Quantum Biology for Brain Diagnostics

edited by

Igor Goryanin

submission deadline 31 Jan 2026 | Viewed by 174 | Submission Open

Keywords: artificial intelligence; quantum biology; neurodiagnostics; biomarkers; neuroimaging; electrophysiology; diagnostics; brain networks

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Emerging Diagnostic Techniques and Therapeutic Strategies in Urological Oncology

edited by

Francesco Chierigo

submission deadline 31 Jan 2026 | Viewed by 172 | Submission Open

Keywords: prostate cancer; screening; biomarkers; genetic testing; imaging; PSMA; artificial intelligence; radical prostatectomy; radiotherapy; hormonal therapies

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advanced Imaging in the Diagnosis and Management of Skin Diseases

edited by Lehang Guo

submission deadline 31 Jan 2026 | Viewed by 159 | Submission Open

Keywords: skin diseases; ultrasound imaging; optical coherence tomography (OCT) imaging; photoacoustic imaging; reflectance confocal microscopy (RCM) imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Frontier Exploration of Multimodal Imaging in Cardiac Rheumatic and Immune Diseases

edited by

Sophie Mavrogeni

submission deadline 31 Jan 2026 | Viewed by 156 | Submission Open

Keywords: myopericarditis; valvular heart disease; coronary artery disease; vasculitis vascular stenosis; vascular aneurysm; reynard phenomenon

Advances in the Diagnosis and Management of Sports Injuries

edited by

Ki-Mo Jang

submission deadline 31 Jan 2026 | Viewed by 155 | Submission Open

Keywords: sports injury; sports medicine; diagnosis; treatment; surgery; rehabilitation

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis, Management, and Prognosis of Liver Disease and Its Syndromes, Second Edition

edited by

Chien Hao Huang

submission deadline 31 Jan 2026 | Viewed by 142 | Submission Open

Keywords: acute liver disease; chronic liver disease; viral hepatitis; liver cirrhosis; non-alcoholic steatohepatitis (NASH); diagnosis; treatment; prognosis score

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Management of Morbid Obesity

edited by Justyna Domienik-Karłowicz

submission deadline 31 Jan 2026 | Viewed by 141 | Submission Open

Keywords: morbid obesity; obesity diagnosis; body composition analysis; visceral adiposity; metabolic syndrome; biomarkers in obesity; genetic predisposition; comorbidity assessment; imaging techniques; risk stratification

(This special issue belongs to the Section Medical Imaging and Theranostics)

Lung Involvement in Connective Tissue Disease: Advances in Diagnosis and Management

edited by Laura Groșeanu

submission deadline 31 Jan 2026 | Viewed by 131 | Submission Open

Keywords: interstitial lung disease; connective tissue disease; complication; etiology; genetic risks; epigenetic changes; dysregulated immunity; CT patterns; mechanisms; screening; assessing; biomarkers

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Role of Magnetic Resonance Imaging in Obesity and Diabetes: 2nd Edition

edited by

Per Lav Madsen

submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open

Keywords: magnetic resonance imaging (MRI); obesity and diabetes; diabetic foot complications; brain atrophy; diabetic kidney disease (DKD); functional MRI; non-invasive imaging; early diagnosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

New Insights into the Diagnosis of Pediatric Cholestasis

edited by Paola Francalanci

submission deadline 31 Jan 2026 | Viewed by 123 | Submission Open

Keywords: extrahepatic cholestasis; intrahepatic cholestasis; biliary atresia; genetic liver disease; inborn errors of metabolism; jaundice; monogenic liver disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis of Peripheral Vascular Diseases

edited by Micaela Iantorno

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: peripheral vascular disease; limb; CT angiography; MR angiography; ankle– brachial index; blood flow

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

New Trends in Ultrasound Imaging

edited by

Ştefan Cristian Vesa

and

Ingrid Andrada Vasilache

submission deadline 15 Feb 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: ultrasound; imaging; diagnostics; artificial intelligence; elastography; contrast-enhanced ultrasound; radiomics; 3D ultrasound; point-of-care ultrasound; interventional imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Acute Kidney Injury and Chronic Kidney Disease: From Pathogenesis to Diagnostics

edited by

Dimitris Kounatidis

and

Natalia G. Vallianou

submission deadline 28 Feb 2026 | 3 articles | Viewed by 14410 | Submission Open

Keywords: acute kidney injury (AKI); chronic kidney disease (CKD); pathogenesis; biomarkers

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in the Diagnosis of Oral and Maxillofacial Disease: 2nd Edition

edited by

Luís Eduardo Almeida

submission deadline 28 Feb 2026 | 8 articles | Viewed by 11182 | Submission Open

Keywords: maxillofacial disease; oral disease; biomarkers; prognosis; periodontal disease; machine learning; MRI; CBCT

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Recent Advances in Diagnostic and Interventional Radiology

edited by

Serena Carriero

submission deadline 28 Feb 2026 | 7 articles | Viewed by 10025 | Submission Open

Keywords: diagnostic radiology; interventional radiology; medical imaging; image-guided therapy; AI; minimally invasive procedures

(This special issue belongs to the Section Medical Imaging and Theranostics)

Maternal–Fetal and Neonatal Diagnostics

edited by Elisa Bevilacqua

submission deadline 28 Feb 2026 | 3 articles | Viewed by 9672 | Submission Open

Keywords: high risk pregnancy; twin pregnancy; maternal– fetal medicine; prenatal diagnosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Contemporary Issues in Maternal-Fetal Medicine

edited by

Themistoklis Dagklis

and

Ioannis Tsakiridis

submission deadline 28 Feb 2026 | 5 articles | Viewed by 9583 | Submission Open

Keywords: obstetrics; high-risk pregnancy; maternal medicine; fetal medicine; prenatal diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management in Otolaryngology 2025

edited by

Rong-San Jiang

submission deadline 28 Feb 2026 | 4 articles | Viewed by 9379 | Submission Open

Keywords: ear; diagnosis; head and neck; management; nose; otolaryngology; throat

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in Echocardiography, 2nd Edition

edited by

Giulia Elena Mandoli

submission deadline 28 Feb 2026 | 6 articles | Viewed by 8489 | Submission Open

Keywords: standard echocardiography; speckle tracking echocardiography; strain; myocardial deformation; 3D echocardiography; valvular reconstruction; differential diagnosis; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Liquid Chromatography–Mass Spectrometry (LC-MS) in the Clinical Laboratory

edited by

Siddabasave Gowda B. Gowda

submission deadline 28 Feb 2026 | 5 articles | Viewed by 7947 | Submission Open

Keywords: LC-MS; clinical diagnostics; biomarker discovery; metabolomics; lipidomics; clinical samples; method validation; precision medicine; analytical techniques

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advances in Molecular Pathology and Imaging for Precision Diagnosis and Treatment of Tumors

edited by

Maurizio Martini

submission deadline 28 Feb 2026 | 6 articles | Viewed by 7793 | Submission Open

Keywords: molecular pathology; molecular imaging; precision oncology; biomarkers; digital pathology; artificial intelligence

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Colorectal Lesions

edited by Andrei Chitul

submission deadline 28 Feb 2026 | 4 articles | Viewed by 7698 | Submission Open

Keywords: colorectal lesions; diagnostic modalities; imaging techniques; machine learning; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Applications of Artificial Intelligence in Gastrointestinal Diseases

edited by Dimitra D. Dionysiou and Ioannis Gallos

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7291 | Submission Open

Keywords: gastrointestinal disease; artificial intelligence; biomarkers; screening/diagnosis; personalized medicine; treatment outcome; pathogenesis; risk management

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Explainable Machine Learning in Clinical Diagnostics

edited by

Kai-Chih Pai

submission deadline 28 Feb 2026 | 5 articles | Viewed by 6662 | Submission Open

Keywords: interpretable machine learning (IML); explainable machine learning; clinical medicine; knowledge integration; global/local explanations

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Computed Tomography Imaging in Medical Diagnosis, 2nd Edition

edited by

Fabio Sandomenico

submission deadline 28 Feb 2026 | 4 articles | Viewed by 6608 | Submission Open

Keywords: computed tomography; medical diagnosis; imaging; internal organs; bones; soft tissue; blood vessels

(This special issue belongs to the Section Medical Imaging and Theranostics)

AI in Dermatology

edited by Jonathan Shapiro

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5833 | Submission Open

Keywords: teledermatology; artificial intelligence; AI algorithms; natural language processing

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Next-Generation Diagnostic Strategies: Bridging Health Sciences and Laboratory Medicine

edited by

Syed M. Shahid

submission deadline 28 Feb 2026 | 1 articles | Viewed by 5359 | Submission Open

Keywords: diabetes mellitus; clinical diagnostics; biomarkers; prevision medicine; glycemic control; digital health

(This special issue belongs to the Section Clinical Laboratory Medicine)

Technological Advances in Oral and Maxillofacial Surgery for Diagnosis

edited by

Maria Giulia Cristofaro

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5317 | Submission Open

Keywords: oral and maxillofacial surgery; oral cancers; maxillofacial trauma; surgical and informatics technology; intraoperative navigation; robotic surgery; oral and maxillofacial surgery reconstruction; nanotechnologies; DNA sequencing

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advancements in the Diagnosis and Management of Liver Disease and Liver Transplantation

edited by Ioana Gabriela Lupescu

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4970 | Submission Open

Keywords: focal and diffuse liver pathology; liver transplantation; MPMRI; MDCT; advanced imaging techniques; specific liver contrast material; imaging biomarkers; interventional radiology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Gynecological Oncology: Advanced Diagnosis and Management in 2025

edited by

Zoard T. Krasznai

and

Rudolf Lampé

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4943 | Submission Open

Keywords: gynecology; oncology; endometrial cancer; ovarian cancer; cervical cancer; diagnosis; staging; surgical methods; standardization of surgery; treatment; innovation; precision medicine; artificial intelligence; machine learning

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Clinical Diagnosis and Management in Anesthesia and Pain Medicine

edited by Jamal Hasoon

submission deadline 28 Feb 2026 | 4 articles | Viewed by 4855 | Submission Open

Keywords: anesthesia and pain medicine; interventional pain management; regional anesthesia; neuromodulation; treatment outcomes; clinical practice patterns; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Current Perspectives and Gaps in the Diagnosis and Management of Rheumatic Diseases

edited by Vikas Majithia

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4802 | Submission Open

Keywords: rheumatology; rheumatic diseases; inflammatory connective tissue diseases; rheumatoid arthritis; systemic lupus erythematosus; vasculitis; spondyloarthritis; scleroderma; osteoarthritis; current perspective; diagnosis; treatment; management

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Imaging of the Future: From the Standardisation of Diagnostic Processes to Artificial Intelligence

edited by

Emanuele David

submission deadline 28 Feb 2026 | 1 articles | Viewed by 4761 | Submission Open

Keywords: artificial intellicence; technologies; ultrasound; MRI; CT; angiography; mammography

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances and Approaches in Managing Neurological Disorders: Multi-Omics and P4 Medicine

edited by

Shashanka Ashili

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4400 | Submission Open

Keywords: multi-omics; neurological disorders; P4 medicine; Appomics; neurodegenerative disorders; neurodevelopmental disorders; personalized medicine; bioinformatics; aging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Thyroid Cancer: Types, Symptoms, Diagnosis and Management

edited by

Mara Carsote

, Mihai-Lucian Ciobica and

Claudiu Nistor

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4364 | Submission Open

Keywords: thyroid neoplasia; thyroiditis; imaging; functional imaging; thyroidectomy; tumor markers; histological exam; molecular findings; pediatric population; pregnancy and thyroid conditions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Clinical Diagnosis and Management in Pediatric Surgery

edited by Ioannis A. Valioulis

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4208 | Submission Open

Keywords: pediatric surgery; neonatal surgery; pediatric urology; pediatric oncology; laparoscopy in children; robotic surgery for children; organ transplantation; diagnostic biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

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