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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition

edited by

Silvia Martu

Liliana-Georgeta Foia

and

Maria Alexandra Mârțu

submission deadline 30 Sep 2025 | Viewed by 180 | Submission Open

Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Lung Imaging: Highlights of Recent Research and Clinical Applications

edited by

Stefano Palmucci

submission deadline 30 Sep 2025 | Viewed by 169 | Submission Open

Keywords: diagnosis; prognosis; lung imaging; markers; clinical practice and patient care

(This special issue belongs to the Section Medical Imaging and Theranostics)

Applications of Electrodiagnosis in Neuromuscular Diseases

edited by

Donggyu Lee

submission deadline 30 Sep 2025 | Viewed by 157 | Submission Open

Keywords: electrodiagnosis; neuromuscular diseases; EMG (electromyography); nerve conduction studies; electrical stimulation

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Translational Research Advances in the Diagnosis of Hematological Diseases

edited by

Robert S. Ohgami

submission deadline 30 Sep 2025 | Viewed by 156 | Submission Open

Keywords: hematologic diseases; genomic diagnostics; digital pathology; biomarker; laboratory diagnostics

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence in Radiation Oncology

edited by Xianjin Dai

submission deadline 30 Sep 2025 | Viewed by 148 | Submission Open

Keywords: artificial intelligence in radiation therapy; deep learning-based auto-segmentation; AI-driven radiotherapy; treatment planning; adaptive radiation therapy with AI radiomics and machine learning for outcome prediction; multi-modal image analysis in radiotherapy; reinforcement learning for dose optimization uncertainty; quantification in AI for radiation oncology; trustworthy and explainable AI in cancer treatment; AI-integrated radiotherapy; workflow automation

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Recent Advances in Microbiome-Based Diagnostics for Oncological Diseases: Innovations and Clinical Applications

edited by

Dana Lucia Stănculeanu

and

Adelina Silvana Gheorghe

submission deadline 30 Sep 2025 | Viewed by 143 | Submission Open

Keywords: microbiome-based diagnostics; disease biomarkers; gut microbiota; cancer microbiome; metagenomics; multi-omics in diagnostics; machine learning in microbiome analysis; dysbiosis and disease; precision medicine; microbiome– host interactions

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Advances in Diagnosis of Hypertension

edited by Vasileios Kotsis

submission deadline 30 Sep 2025 | Viewed by 124 | Submission Open

Keywords: hypertension; diagnosis; biomarkers; digital health; early detection

(This special issue belongs to the Section Clinical Laboratory Medicine)

Recent Advances in Diagnosis and Management of Breast Cancer

edited by Wing Lok Wendy Chan

submission deadline 30 Sep 2025 | Viewed by 123 | Submission Open

Keywords: breast cancer; diagnosis; treatment; personalized medicine; imaging techniques; immunotherapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Enhancements in Screening Pathways for Early Detection of Lung Cancer

edited by

Paolo Albino Ferrari

and

Antonio Maccio

submission deadline 30 Sep 2025 | Viewed by 122 | Submission Open

Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Cardiometabolic Disease: Diagnosis and Management

edited by Muhammad Shariq Usman

submission deadline 30 Sep 2025 | Viewed by 121 | Submission Open

Keywords: cardiometabolic disease; diagnosis; management; diabetes; obesity; personalized medicine

(This special issue belongs to the Section Clinical Laboratory Medicine)

The Role of Diagnostic Imaging in Musculoskeletal Pain

edited by Ian Young

submission deadline 30 Sep 2025 | Viewed by 104 | Submission Open

Keywords: diagnostic imaging; musculoskeletal pain; imaging techniques (or imaging modalities); diagnostic accuracy; clinical applications; pain management

(This special issue belongs to the Section Medical Imaging and Theranostics)

Pathology and Molecular Diagnosis of Vascular Diseases

edited by

Francisco S. Lozano Sánchez

and María Begoña García-Cenador

submission deadline 30 Sep 2025 | Viewed by 103 | Submission Open

Keywords: vascular pathology; molecular diagnostics; precision medicine; biomarkers; atherosclerosis; thrombosis; vascular imaging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Nuclear Medicine and Molecular Imaging in Cancer Diagnosis, Therapy, and Treatment Assessment

edited by

Sara Harsini

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1795 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET/CT; theranostics; cancer diagnosis; treatment monitoring

(This special issue belongs to the Section Medical Imaging and Theranostics)

Deep Learning and Multimodal Feature Fusion for Advanced Medical Imaging Diagnosis

edited by

Sarmad Maqsood

and

Rytis Maskeliūnas

submission deadline 30 Oct 2025 | 1 articles | Viewed by 798 | Submission Open

Keywords: deep learning; feature fusion; medical imaging; artificial intelligence in healthcare; diagnostic imaging; multimodal data integration; explainable AI; clinical decision support

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Deep Learning in Medical Imaging: Challenges and Opportunities

edited by Morten Bo Søndergaard Svendsen

submission deadline 30 Oct 2025 | Viewed by 230 | Submission Open

Keywords: deep learning; artificial intelligence; medical imaging; endoscopy; image segmentation; medical image processing

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Cardiothoracic Imaging: Recent Techniques and Applications in Diagnostics, Second Edition

edited by

Giacomo Sica

submission deadline 31 Oct 2025 | 11 articles | Viewed by 32853 | Submission Open

Keywords: emergency; cardiac imaging; thoracic imaging; aorta; MRI; CT; radiomics; artificial intelligence; ILD

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Machine Learning for Computer-Aided Diagnosis in Biomedical Imaging—2nd Edition

edited by

Farhan Akram

submission deadline 31 Oct 2025 | 14 articles | Viewed by 25174 | Submission Open

Keywords: cancer diagnosis; medical images; electronic health records; machine learning; deep learning; artificial intelligence; explainable AI models; multi-modal analysis; federated learning; CAD systems

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Deep Learning in Medical Image Segmentation and Diagnosis

edited by Rahib Abiyev

submission deadline 31 Oct 2025 | 11 articles | Viewed by 23465 | Submission Open

Keywords: deep learning in medical diagnosis; medical imaging and deep learning; data mining and deep learning; emerging deep learning techniques and diagnosis; deep learning for the classification of lesions and disease; deep learning for segmentation; denoising; and super resolution; deep learning for signal analysis; learning mechanisms in deep neural networks; ensemble learning; stacked networks; medical informatics; computer-assisted diagnosis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in the Diagnosis and Management of Cardiovascular Diseases

edited by Fabrizio Guarracini and Cristina Giannattasio

submission deadline 31 Oct 2025 | 20 articles | Viewed by 21819 | Submission Open

Keywords: cardiovascular disease; risk stratification; preventive cardiology; hypertension; dyslipidaemias; heart failure management; interventional cardiology; coronary artery disease; arrythmias

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Assessment and Diagnosis of Cognitive Disorders

edited by

Elena Cecilia Rosca

submission deadline 31 Oct 2025 | 7 articles | Viewed by 19383 | Submission Open

Keywords: cognitive disorders; neurology; neuroimaging; biomarkers; diagnosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Ultrasound

edited by

Rute Santos

submission deadline 31 Oct 2025 | 11 articles | Viewed by 16595 | Submission Open

Keywords: quantitative ultrasound techniques; ultrasound tissue characterization; ultrasound-guided therapy or intervention; clinical applications of diagnostic ultrasound; ultrasound imaging processing; diagnostic ultrasound devices

(This special issue belongs to the Section Medical Imaging and Theranostics)

A New Era in Diagnosis: From Biomarkers to Artificial Intelligence

edited by

Tudor Drugan

and

Daniel Leucuta

submission deadline 31 Oct 2025 | 10 articles | Viewed by 15152 | Submission Open

Keywords: diagnosis; precision medicine; predictive diagnostics; therapeutic strategies; biomarkers; artificial intelligence; machine learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Prognosis of Heart Disease, 2nd Edition

edited by

Yuli Huang

submission deadline 31 Oct 2025 | 8 articles | Viewed by 13603 | Submission Open

Keywords: heart disease; coronary artery disease; arrhythmia; heart failure; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Sports Medicine

edited by

Luis Manuel Martínez Aranda

and

Jacobo Á. Rubio Arias

submission deadline 31 Oct 2025 | 6 articles | Viewed by 12861 | Submission Open

Keywords: diagnosis; sports injuries; injury frequency; ligaments; strain; tendon injuries; sport-related concussion; injury treatment; return to play; musculoskeletal rehabilitation

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Management of Vasculitis

edited by

Alicia Rodríguez-Pla

submission deadline 31 Oct 2025 | 8 articles | Viewed by 12418 | Submission Open

Keywords: vasculitis; advances; updates; management; treatment; therapy

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis, Prognosis and Management of Hematologic Malignancies

edited by

Rossella Cacciola

Emma C. Cacciola

, Alessandra Romano and Alessandro Allegra

submission deadline 31 Oct 2025 | 6 articles | Viewed by 11542 | Submission Open

Keywords: leukemia; myeloproliferative neoplasms; myeloma; lymphoma

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Fetal Cardiology

edited by Maciej Słodki

submission deadline 31 Oct 2025 | 4 articles | Viewed by 10806 | Submission Open

Keywords: fetal cardiology; echocardiography; medical imaging; diagnosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Endoscopy in Diagnosis of Gastrointestinal Disorders—2nd Edition

edited by

Miguel Mascarenhas

submission deadline 31 Oct 2025 | 8 articles | Viewed by 10377 | Submission Open

Keywords: endoscopy; gastroenterology; coloproctology; digestive healthcare; artificial intelligence; digestive oncology; colonoscopy; capsule endoscopy; upper endoscopy

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advancements in Artificial Intelligence for Dentomaxillofacial Radiology—2nd Edition

edited by

Andre Luiz Ferreira Costa

Kaan Orhan

and

Sérgio Lúcio Pereira de Castro Lopes

submission deadline 31 Oct 2025 | 7 articles | Viewed by 9895 | Submission Open

Keywords: artificial intelligence; deep learning; dentomaxillofacial radiology; dentistry; diagnosis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in the Diagnosis and Management of Head and Neck Disease

edited by

Cristiana Lo Nigro

submission deadline 31 Oct 2025 | 8 articles | Viewed by 9776 | Submission Open

Keywords: head and neck disease; oral and maxillofacial disease; throat cancer; thyroid disease; otolaryngology tumor

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis of Skin Disease

edited by

Gerardo Cazzato

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9162 | Submission Open

Keywords: dermatology; dermatopathology; skin diseases; neoplastic diseases; inflammatory dermatopathology; CTCL; melanoma; squamous cell carcinoma; basal cell carcinoma; infectious diseases

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Thyroid Disorders

edited by Vladan Zivaljevic

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9097 | Submission Open

Keywords: thyroid disease management; diagnosis of thyroid disease; novel procedures; thyroid disorders; thyroid cancer

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Management of Gynecological Oncology

edited by

Elena Bernad

and

Marius L. Craina

submission deadline 31 Oct 2025 | 6 articles | Viewed by 8662 | Submission Open

Keywords: female genital neoplasms; breast neoplasms; screening; diagnosis; treatment; surgery; medical oncology; psycho-oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Treatment of Pediatric Emergencies—2nd Edition

edited by

Katerina Kambouri

submission deadline 31 Oct 2025 | 4 articles | Viewed by 7713 | Submission Open

Keywords: pediatric emergency; diagnosis; pathology; management

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Clinical Applications and Potential of Magnetic Resonance Spectroscopy

edited by Jimin Ren

submission deadline 31 Oct 2025 | 4 articles | Viewed by 7663 | Submission Open

Keywords: magnetic resonance spectroscopy; metabolite; lipids and phospholipids; brain; skeletal muscle

(This special issue belongs to the Section Medical Imaging and Theranostics)

Optical Coherence Tomography in Diagnosis of Ophthalmology Disease

edited by Ninel Z Gregori and Lisa C. Olmos de Koo

submission deadline 31 Oct 2025 | 7 articles | Viewed by 7645 | Submission Open

Keywords: adaptive optics; multimodal imaging; optical coherence tomography; retinal diseases; spectral-domain optical coherence tomography; swept-source optical copherence tomography

(This special issue belongs to the Section Biomedical Optics)

Advances in the Diagnosis and Management of Thyroid Cancer

edited by

Kwangsoon Kim

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6848 | Submission Open

Keywords: thyroid cancer; diagnosis; surgery; recurrence; theranostics; prognosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

New Radiological, Electrocardiographic and Biochemical Cardiovascular Risk Factors in 2025

edited by

Paweł Gać

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6275 | Submission Open

Keywords: cardiovascular medicine; risk factors; heart and vascular biology; imaging diagnostics; electrocardiogram; biochemistry; toxicology; experimental medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Technologies in Orthopedic Surgery: Diagnosis and Management

edited by Giuseppe Salvatore

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6272 | Submission Open

Keywords: orthopedic surgery; orthopedic diagnosis; orthopedics; computer navigation and augmented reality; robotics; digital templating; 3D Printing; artificial intelligence; machine learning; deep learning

(This special issue belongs to the Section Medical Imaging and Theranostics)

Pediatric Gastrointestinal Pathology

edited by Juan Putra

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6264 | Submission Open

Keywords: inflammatory bowel disease; crohn disease; celiac disease; ulcerative colitis; vascular anomalies; eosinophilic esophagitis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Diagnosis and Prognosis of Breast Cancer

edited by Domen Ribnikar

submission deadline 31 Oct 2025 | 5 articles | Viewed by 5620 | Submission Open

Keywords: breast cancer; gene expression profiling in breast cancer; cancer biomarkers; tumor biology; prediction; prognosis; systemic treatment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Risk Factors for Frailty in Older Adults

edited by

Agustín Aibar Almazán

submission deadline 31 Oct 2025 | 5 articles | Viewed by 5548 | Submission Open

Keywords: frailty; older adults; risk factors; chronic diseases; nutritional deficiencies; physical inactivity; social determinants; genetic predispositions; preventive measures; interventions; quality of life; health outcomes

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence in Clinical Decision Support—2nd Edition

edited by

Qingqing Mao

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5013 | Submission Open

Keywords: artificial intelligence; machine learning; clinical decision support; predictive modeling; patient monitoring; diagnostic support; treatment recommendation; safety and privacy

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Dermatology and Venereology: Diagnosis and Management

edited by

Giulia Ciccarese

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4840 | Submission Open

Keywords: skin infections; sexually transmitted infections; human papillomavirus; syphilis; pityriasis rosea; exanthem

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in Musculoskeletal Imaging: From Diagnosis to Treatment

edited by

Chiara Martini

and Massimo De Filippo

submission deadline 31 Oct 2025 | 5 articles | Viewed by 4784 | Submission Open

Keywords: musculoskeletal imaging; artificial intelligence; bone imaging; musculoskeletal ultrasound; diagnosis; machine learning algorithms

(This special issue belongs to the Section Medical Imaging and Theranostics)

Generative AI and Deep Learning in Medical Diagnostics

edited by

Steven L. Fernandes

submission deadline 31 Oct 2025 | 1 articles | Viewed by 4278 | Submission Open

Keywords: generative AI; medical diagnostics; medical imaging processing and analysis; deep learning; machine learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Machine Learning for Medical Image Processing and Analysis

edited by Wei Shao

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3805 | Submission Open

Keywords: machine learning; medical image processing; diagnostic accuracy; healthcare; algorithms

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

PET/CT Diagnostics and Theranostics

edited by

Salvatore Annunziata

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3520 | Submission Open

Keywords: PET/CT; diagnostics; theranostics; medical imaging; development

(This special issue belongs to the Section Medical Imaging and Theranostics)

Optimizing Personalized Radiation Dose in Computed Tomography: Justification and Diagnostic Reference Levels

edited by

Mohamed Abuzaid

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3451 | Submission Open

Keywords: computed tomography; personalized radiation dose; computed tomography optimization; diagnostic reference levels; radiation dose justification; CT dose management; AI applications in dose management

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Management of Musculoskeletal Diseases

edited by Kavithalakshmi Sataranatarajan

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3326 | Submission Open

Keywords: musculoskeletal diseases; pathological diagnosis; high-resolution imaging; muscle biopsy; biomarkers; genetic testing

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

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