Recent Advances in the Diagnosis and Management of Gynecological Cancers

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 577

Special Issue Editor


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Guest Editor
1. Department of Gynecology with Center for Oncological Surgery, Charite Universitatsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
2. Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, Berlin, Germany
Interests: gynecologic oncology; minimally invasive surgical techniques; reproductive endocrinology; early disease detection and screening methodologies
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Special Issue Information

Dear Colleagues,

Gynecological cancers, including ovarian, cervical, endometrial, vulvar, and vaginal cancers, represent a significant global health challenge. Early and accurate diagnosis, alongside advanced treatment strategies, is essential for improving patient outcomes. This Special Issue aims to explore recent advancements in the diagnosis and management of gynecological malignancies, emphasizing innovative imaging techniques, biomarker research, and molecular profiling for precise disease characterization. Additionally, it focuses on state-of-the-art treatment approaches, including minimally invasive surgery, targeted therapies, immunotherapy, and personalized treatment protocols. Special attention will be paid to emerging challenges such as resistance to therapy, quality of life considerations, and disparities in cancer care. By bringing together expert perspectives and the latest clinical and translational research, this Special Issue aims to enhance current diagnostic and therapeutic strategies, ultimately improving survival rates and patient care in gynecological oncology.

Prof. Dr. Zelal M. Muallem
Guest Editor

Manuscript Submission Information

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Keywords

  • gynecological cancers
  • diagnosis and staging
  • molecular biomarkers
  • targeted therapies
  • immunotherapy
  • minimally invasive surgery
  • personalized medicine
  • cancer resistance
  • quality of life in oncology
  • disparities in cancer care

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Published Papers (1 paper)

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Review

12 pages, 762 KiB  
Review
Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols
by Mustafa Zelal Muallem and Ahmad Sayasneh
Diagnostics 2025, 15(9), 1174; https://doi.org/10.3390/diagnostics15091174 - 6 May 2025
Viewed by 476
Abstract
Cervical cancer remains a significant health challenge globally, with locally advanced cervical cancer (LACC) representing a particularly complex subset due to its diverse definitions and varied treatment approaches. The absence of randomized controlled trials comparing the upfront radical surgery followed by concurrent chemoradiotherapy [...] Read more.
Cervical cancer remains a significant health challenge globally, with locally advanced cervical cancer (LACC) representing a particularly complex subset due to its diverse definitions and varied treatment approaches. The absence of randomized controlled trials comparing the upfront radical surgery followed by concurrent chemoradiotherapy (CCRT) or chemotherapy alone for clearly defined risk factors for LACC hinders the development of standardized treatment protocols, leading to disparities in patient outcomes across different healthcare settings. This paper seeks to underline the necessity of a consensus on the definition of LACC and aims to comprehensively and critically review the existing literature trying to harmonize treatment strategies and improve prognostic outcomes. Our analysis suggests a multimodal approach for treating FIGO IB3, IIA2, and selected IIB cases at facilities capable of delivering highly curative nerve-sparing surgical interventions, with the goal of bridging the gap in current treatment methodologies. Preliminary findings suggest that adopting a standardized definition could facilitate more consistent treatment outcomes and enhance comparative research. Full article
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