Chronic Fatigue Syndrome: Clinical Diagnostics, Management, and Prognosis
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 164
Special Issue Editors
Interests: cardiovascular; neurocardiology; authonomic
Interests: post-viral syndromes; ME/CFS; allergy; barrier function; immunomodulation; microbiota; immunonutrition; gastrointestinal immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a severe, debilitating disorder that has garnered increasing attention from both the scientific community and the general public, particularly in the aftermath of the COVID-19 pandemic. Although this condition has been recognized since the mid-20th century, the majority of research in this field has emerged over the last decade.
Despite numerous studies, pathophysiological mechanisms and effective treatment strategies in ME/CFS remain incompletely understood. The complexity of this condition often necessitates a multidisciplinary approach involving neurology, immunology, cardiology, rheumatology, and other specialties, both in diagnosis and management. This is particularly relevant given that approximately three quarters of patients develop symptoms following a "flu-like" illness, and a substantial proportion of affected individuals remain undiagnosed. Additionally, diagnostic challenges arise due to the overlap with various other post-infectious syndromes, such as Lyme disease.
Consequently, ME/CFS constitutes a broad and dynamic area of research that intersects multiple scientific disciplines, including infectious diseases, immunology, dysautonomia, gut microbiome studies, and mitochondrial disorders.
The objective of this Special Issue is to investigate various aspects of the diagnosis, management, and prognosis of ME/CFS, and we encourage contributions from researchers and studies across diverse fields in contemporary medicine.
Prof. Dr. Branislav Milovanovic
Dr. Eva Untersmayr
Guest Editors
Manuscript Submission Information
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Keywords
- chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
- post-COVID-19 illness
- post-infection syndromes
- autonomic nervous system
- Lyme disease
- immunology
- gut microbiota
- chronic infection
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