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5.9
3.3
Journals
Diagnostics
Special Issues
New Insights into the Diagnosis of Neurological Disorders
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New Insights into the Diagnosis of Neurological Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 255

Special Issue Editor

Dr. Yukai Cheng

E-Mail Website
Guest Editor
Department of Neurosurgery, China Medical University Hospital, Taichung 404, Taiwan
Interests: endoscopic neurosurgery; functional neurosurgery; pediatric neurosurgery

Special Issue Information

Dear Colleagues,

We are excited to invite contributions to our Special Issue on "New Insights into the Diagnosis of Neurological Disorders". This collection aims at highlighting the latest research and developments in the diagnosis of neurological disorders, focusing on innovations that enhance diagnostic accuracy and patient outcomes.

This Special Issue will cover a range of topics, including, but not limited to, the following:

  • Advanced neuroimaging techniques and their applications in early diagnosis.
  • Research on biomarkers for neurological disorders.
  • Novel diagnostic methods based on genomics and molecular analysis.
  • The role of artificial intelligence and machine learning in diagnosing neurological diseases.
  • Multidisciplinary approaches and challenges in neurological diagnosis.

Our goal is to publish high-quality scientific articles that offer new insights into modern diagnostic methods for neurological conditions. We welcome original research articles, case studies, case reports, and reviews covering various aspects of early detection and innovative diagnostic tools.

We look forward to your valuable contributions to this important field.

Best regards,

Dr. Yukai Cheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurological disorders
  • genomics
  • molecular biology
  • artificial intelligence
  • machine learning

Benefits of Publishing in a Special Issue

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

12 pages, 462 KB  
Article
A Specific Haplotype of the MMP2 Gene Promoter May Increase the Risk of Developing Cerebral Palsy
by Ana Djuranovic Uklein, Natasa Cerovac, Dijana Perovic, Nela Maksimovic, Biljana Jekic, Milka Grk, Marija Dusanovic Pjevic, Milica Rasic, Natasa Stojanovski, Milica Pesic, Ivana Novakovic and Tatjana Damnjanovic
Diagnostics 2025, 15(24), 3178; https://doi.org/10.3390/diagnostics15243178 - 12 Dec 2025
Abstract
Background/Objectives: Hypoxic–ischemic encephalopathy (HIE) is a common neurological outcome of perinatal asphyxia, with cerebral palsy (CP) being the most severe lasting effect. Perinatal brain injury activates the immune system and induces the release of inflammatory mediators. Matrix Metalloproteinases (MMPs) play a crucial role [...] Read more.
Background/Objectives: Hypoxic–ischemic encephalopathy (HIE) is a common neurological outcome of perinatal asphyxia, with cerebral palsy (CP) being the most severe lasting effect. Perinatal brain injury activates the immune system and induces the release of inflammatory mediators. Matrix Metalloproteinases (MMPs) play a crucial role in neuroinflammation and neurodegeneration. This study explored the potential link between MMP2 promoter polymorphisms and the development of CP in children with a history of perinatal asphyxia. Methods: We enrolled 212 patients (130 males and 82 females) with documented perinatal asphyxia, who underwent a comprehensive neurological assessment and neuroimaging, including ultrasound and magnetic resonance imaging (MRI). We genotyped the MMP2 promoter polymorphisms rs243866, rs243865, and rs243864 using real-time polymerase chain reaction. Haplotype frequencies were calculated using Haploview software. Results: As expected, patients with HIE are more likely to develop CP (p = 0.000). In a study of 104 patients who developed CP, the frequencies of the A (rs243866), T (rs243865), and G alleles (rs243864) were nearly twice as high compared to those without CP (p = 0.008, p = 0.019, and p = 0.008, respectively). Haplotype analysis supported these findings, showing that the ATG haplotype was significantly more common among patients who developed CP (p = 0.004). Additionally, in patients with MRI-confirmed brain damage, the ATG haplotype was more frequently observed (p = 0.019). Conclusions: The ATG haplotype of the MMP2 promoter may indicate a risk factor for developing cerebral palsy (CP) in patients who experience perinatal asphyxia and could serve as a potential diagnostic predictor of CP. Full article
(This article belongs to the Special Issue New Insights into the Diagnosis of Neurological Disorders)
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