Cachexia: Molecular Mechanisms and Treatment Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 15 August 2025 | Viewed by 117
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer cachexia (CC) affects over 80% of all cancer patients, is associated with a poor prognosis, and directly contributes to more than 30% of cancer-related deaths. It also leads to unresponsiveness to therapy and reduced life expectancy. Despite its prevalence, the clinical management of CC remains unsatisfactory. This inadequacy arises from the challenges of early diagnosis, the lack of adequate biomarkers (where diagnosis and prognosis often rely on non-specific body mass indexes), and therapeutic options. Currently, there is insufficient evidence supporting any pharmacologic agent specifically designed for CC. Most therapies depend on broad anti-inflammatory drugs, which have limited effectiveness, and on high-protein, high-calorie nutrient-dense foods administered without personalized treatment approaches.
Recent findings indicate that the pathophysiology of CC involves various organs and distinct inflammatory, hormonal, and metabolic pathways. However, our understanding of the communication between organs in this context is still largely incomplete.
In this Special Issue, we invite contributions that explore the complexities of cancer cachexia (CC), including its endotypes, prevention, development, treatment, nutritional aspects, and regulatory mechanisms. We particularly encourage original research articles that identify distinct subtypes of CC, as well as comprehensive reviews summarizing the current state of this complex field. We welcome translational, and preclinical studies, including both in vitro and in vivo models, that provide novel insights into the underlying mechanisms of CC.
Dr. Zoltán Lohinai
Guest Editor
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Keywords
- cachexia
- cancer metabolism
- dietary interventions
- inflammation
- malnutrition
- cachexia biomarkers
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