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Cells
Special Issues
Cellular and Molecular Players in Bone Homeostasis
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Cellular and Molecular Players in Bone Homeostasis

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (1 August 2025) | Viewed by 134

Special Issue Editor

Dr. Darja Andreev

E-Mail Website
Guest Editor
1. Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany
2. Deutsches Zentrum für Immuntherapie (DZI), 91054 Erlangen, Germany
Interests: osteoimmunology; autoimmune diseases; bone

Special Issue Information

Dear Colleagues,

The Special Issue “Cellular and Molecular Players in Bone Homeostasis” aims to provide a comprehensive exploration of the intricate cellular and molecular mechanisms governing bone health and stability. This Issue invites original research and review articles that focus on the diverse cell populations found in bone, including skeletal stem cells, osteoblasts, osteocytes, osteoclasts, and adipocytes, and the molecular factors regulating their function. Special attention will be given to the roles of microenvironmental factors such as immune cells, stromal cells, blood supply (hypoxia), and energy metabolism in shaping bone homeostasis. We also welcome studies addressing how disruptions in these tightly regulated systems contribute to bone-related diseases such as fractures, osteoporosis, arthritis, and bone cancers. Manuscripts investigating the cross-talk between bone cells and their microenvironment, the impact of systemic conditions, and novel therapeutic targets are particularly encouraged. This Special Issue seeks to highlight cutting-edge research and foster a deeper understanding of the dynamic balance required to maintain bone integrity, as well as the pathological processes that lead to its breakdown. By bridging molecular, cellular, and translational insights, this Issue aims to advance the field of bone biology and inspire future innovations in disease management and therapy.

Dr. Darja Andreev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone homeostasis
  • cellular and molecular mechanisms
  • bone-related diseases
  • microenvironmental factors
  • therapeutic targets

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Published Papers (1 paper)

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Research

16 pages, 2208 KiB  
Article
Cell Culture in a Hyperbaric Chamber: A Research Model to Study the Effects of Hyperbarism (Hyperbaric Pressure) on Bone Cell Culture
by Alessia Mariano, Valerio Consalvi, Enrico Marchetti, Angelo Rodio, Anna Scotto d’Abusco and Luigi Fattorini
Cells 2025, 14(16), 1287; https://doi.org/10.3390/cells14161287 - 19 Aug 2025
Abstract
The hyperbaric environment, to which many categories of workers are exposed, can provoke injuries that can lead to various types of disorders. A major part of the studies aiming to explore the causes/effects leading to these injuries are conducted in vivo. In the [...] Read more.
The hyperbaric environment, to which many categories of workers are exposed, can provoke injuries that can lead to various types of disorders. A major part of the studies aiming to explore the causes/effects leading to these injuries are conducted in vivo. In the present manuscript, we describe the effects on osteoblast cell cultures stressed in a hyperbaric purpose-built chamber, using an in vitro model to analyze the affected pathways. A hyperbaric chamber for cell cultures was constructed by adapting a pressurized test chamber originally designed for technical use. The MG-63 cell line and human primary osteoblasts were placed into this chamber at different atm and exposure times, at 37 °C. After treatment, the chamber was depressurized by performing controlled decompression stops. Then, the pro-inflammatory cytokines and bone tissue biomarker expression were analyzed. The stress conditions induced the overexpression of pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, along with reactive oxygen species release. Moreover, the alteration of bone tissue marker production was observed. In particular, the increase in Receptor Activator of NF-κB Ligand (RANKL) and the decrease in Osteoprotegerin (OPG) were detected. Further modulation was observed regarding other biomarkers, Alkaline phosphatase, Osteocalcin, Bone Morphogenetic Protein-2, and mainly Collagen type I, all of which were downregulated by treatment. Taken together, these findings account for certain illnesses, such as dysbaric osteonecrosis, diagnosed in workers exposed to a hyperbaric environment. Inflammation induced by this kind of stress affects several factors involved in bone tissue homeostasis, leading to bone injuries, which are among the typical disorders observed in divers. Full article
(This article belongs to the Special Issue Cellular and Molecular Players in Bone Homeostasis)
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