Increasing Incidence of Retinal Disorders: Addressing Preclinical Studies with Appropriate Animal Models and Advanced Methodologies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 150
Special Issue Editors
Interests: animal models; ocular diseases; retinal function; neurodegeneration; neuroprotection; anti-angiogenic and anti-inflammatory compounds; dietary supplementation
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegeneration; neoangiogenesis; retinal ganglion cells; neurovascular unit; diabetic retinopathy; retinopathy of prematurity; age-related macular degeneration; retinitis pigmentosa; full-field electroretinogram
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The globally increasing incidence of blinding diseases including wet AMD, glaucoma and diabetic retinopathy should be more thoroughly studied, with particular attention to suitable animal models and advanced methodologies. An appropriate animal model can elucidate some fundamental aspects of a human disease to promote a greater understanding of its mechanism and enable the translational development of therapeutic or diagnostic modalities. Mice have been the dominant animal models in retinal diseases over the past 30 years. Their prevalent use has been driven by several key attributes including their small size, favorable genetic manipulation, relatively short generation time, and affordable cost compared to other mammals. However, there remain key limitations in the questions that can be addressed in these rodent models. At the methodological level, morpho-functional studies in the retina have been implemented via its molecular analysis, whereas the use of electroretinography should be expanded. Additionally, new advances in biomedical optics may offer many promising tools for retinal imaging. The present Special Issue seeks to synthesize current knowledge of retinal disorders in established model organisms with advances in methodologies to suggest new approaches to understand mechanisms underlying retinal diseases in humans.
Prof. Dr. Paola Bagnoli
Dr. Maurizio Cammalleri
Guest Editors
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Keywords
- hypoxia
- oxidative stress
- angiogenic markers
- HIF-1/VEGF axis
- retinal diseases
- β-adrenoceptors
- electroretinographic responses
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