DNA Damage and Repair for Targeted Cancer Therapy

Dear Colleagues,

DNA damage and repair mechanisms, including BER, NER, MMR, HR, and NHEJ, are crucial for genomic integrity. In cancer, these mechanisms are often dysregulated, making the cells vulnerable to targeted therapies. Inhibitors, e.g., PARP-I, kill cancer cells by accumulating DNA damage in HR-deficient cells, while ATR and ATM inhibitors target key regulators of the DNA damage response, sensitizing cells to these agents. Challenges such as resistance, toxicity, and the need for reliable biomarkers remain, but ongoing research seeks to overcome these obstacles.

In this Special Issue, we welcome research and review articles on DNA damage and repair, focusing on key repair pathways and their vulnerabilities in cancer cells. We also invite studies addressing resistance, toxicity, and biomarker identification. This issue aims to highlight how targeted therapies can enhance treatment efficacy and advance personalized cancer care.

Dr. Mohd Saleem Dar
Dr. Mohsin Maqbool
Dr. Sajad Ahmad Bhat
Guest Editor

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