Drosophila as a Model for Understanding Human Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 926

Special Issue Editor


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Guest Editor
Department of Medicine, Center for Precision Disease Modeling, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD 21201, USA
Interests: Drosophila; kidney diseases; cardiomyopathy; integrin; collagen; model organism; genetics

Special Issue Information

Dear Colleagues,

I am delighted to invite you to contribute to a Special Issue of Cells titled “Drosophila as a Model for Understanding Human Disease”. This Special Issue aims to highlight the versatile and powerful contributions of Drosophila melanogaster as a model organism in understanding the molecular and genetic basis of human diseases.

For over a century, Drosophila has served as an indispensable tool for studying fundamental biological processes and disease mechanisms due to its conserved genetics, rapid generation time, and ease of genetic manipulation. The availability of sophisticated genetic tools, along with their low cost and high throughput, has positioned Drosophila as a pivotal model for exploring diverse human conditions, including neurodegenerative diseases, cancer, cardiovascular disorders, metabolic syndromes, and rare genetic diseases. This Special Issue seeks to provide a comprehensive collection of cutting-edge studies that leverage the strengths of Drosophila to gain insights into human health and disease.

We welcome original research articles, reviews, and methodological papers on a wide range of topics related to the use of Drosophila in disease modeling. Submissions are open to studies that investigate fundamental mechanisms, develop new tools or methodologies, or explore translational applications in Drosophila.

We look forward to your valuable contributions to this exciting Special Issue. If you have any questions or wish to discuss your submission idea, please do not hesitate to contact me.

Dr. Zhe Han
Guest Editor

Manuscript Submission Information

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Keywords

  • Drosophila melanogaster
  • human disease models
  • genetic and molecular mechanisms
  • neurodegenerative diseases
  • cardiovascular diseases
  • cancer biology
  • metabolic disorders
  • high-throughput screening
  • precision medicine
  • translational research

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Published Papers (1 paper)

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Research

24 pages, 4533 KiB  
Article
Anti-Tumor Effects of Cecropin A and Drosocin Incorporated into Macrophage-like Cells Against Hematopoietic Tumors in Drosophila mxc Mutants
by Marina Hirata, Tadashi Nomura and Yoshihiro H. Inoue
Cells 2025, 14(6), 389; https://doi.org/10.3390/cells14060389 - 7 Mar 2025
Viewed by 717
Abstract
Five major antimicrobial peptides (AMPs) in Drosophila are induced in multiple sex combs (mxc) mutant larvae harboring lymph gland (LG) tumors, and they exhibit anti-tumor effects. The effects of other well-known AMPs, Cecropin A and Drosocin, remain unexplored. We investigated the [...] Read more.
Five major antimicrobial peptides (AMPs) in Drosophila are induced in multiple sex combs (mxc) mutant larvae harboring lymph gland (LG) tumors, and they exhibit anti-tumor effects. The effects of other well-known AMPs, Cecropin A and Drosocin, remain unexplored. We investigated the tumor-elimination mechanism of these AMPs. A half-dose reduction in either the Toll or Imd gene reduced the induction of these AMPs and enhanced tumor growth in mxcmbn1 mutant larvae, indicating that their anti-tumor effects depend on the innate immune pathway. Overexpression of these AMPs in the fat body suppressed tumor growth without affecting cell proliferation. Apoptosis was promoted in the mutant but not in normal LGs. Conversely, knockdown of them inhibited apoptosis and enhanced tumor growth; therefore, they inhibit LG tumor growth by inducing apoptosis. The AMPs from the fat body were incorporated into the hemocytes of mutant but not normal larvae. Another AMP, Drosomycin, was taken up via phagocytosis factors. Enhanced phosphatidylserine signals were observed on the tumor surface. Inhibition of the signals exposed on the cell surface enhanced tumor growth. AMPs may target phosphatidylserine in tumors to induce apoptosis and execute their tumor-specific effects. AMPs could be beneficial anti-cancer drugs with minimal side effects for clinical development. Full article
(This article belongs to the Special Issue Drosophila as a Model for Understanding Human Disease)
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