Lung Development: Challenges and Opportunities

Dear Colleagues,

Lung development is a complex, highly regulated process that begins at embryogenesis and continues into postnatal life, culminating in the formation of a fully functional respiratory system. The intricate interplay between alveolar stem and progenitor cells, endothelial networks, mesenchymal components, and the extracellular matrix shapes the three-dimensional architecture of alveoli, ensuring efficient gas exchange. However, disruptions to these processes due to genetic, environmental, or pathological factors can lead to impaired lung development, chronic lung diseases, and limited regenerative capacity following injury.

This Special Issue will explore the latest advances in our understanding of alveolarization, alveolar damage repair, and lung regeneration. We invite contributions that investigate the cellular and molecular mechanisms underlying lung development, with a particular focus on the role of alveolar stem and progenitor cells, endothelial cells, and mesenchymal interactions. Studies addressing the biophysical properties of alveoli, their microenvironment, and the impact of mechanical forces on lung morphogenesis are highly encouraged. Additionally, we welcome research on translational approaches to regenerative medicine, including stem-cell-based therapies and bioengineering strategies for lung tissue repair.

By bringing together cutting-edge research and expert reviews, this Special Issue will provide new insights into both the challenges and opportunities in lung development and regeneration.

Dr. David Warburton
Guest Editor

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