The Dynamic Gut Wall: Innovations and Future Directions in Intestinal Epithelium
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 August 2025 | Viewed by 132
Special Issue Editors
Interests: intestinal stem cells; inflammatory bowel disease; intestinal cancer; signaling; chromatin
Special Issues, Collections and Topics in MDPI journals
Interests: epithelial renewal; gut barrier function; innate immune signaling; functional microbiome research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The intestinal epithelium is a highly dynamic tissue, crucial for nutrient absorption, immune defense, and maintaining gut microbiome balance. Its remarkable regenerative capacity, fueled by intestinal stem cells, enables rapid turnover and repair after injury. Recent advances have shed light on the molecular and cellular mechanisms governing epithelial renewal, barrier function, and interactions with the immune system and microbiota. These insights have unveiled novel opportunities to target intestinal diseases, such as inflammatory bowel disease, colorectal cancer, and enteropathies, through precision therapies and bioengineered solutions.
This Special Issue aims to explore the latest innovations and future directions in studying and harnessing the intestinal epithelium’s dynamic nature. Topics of interest include cutting-edge research on stem cell-based regenerative approaches, organoid modeling of intestinal physiology and pathology, advancements in gut-on-chip technologies, and emerging insights into epithelial–immune–microbiota crosstalk.
We also welcome contributions on therapeutic interventions leveraging molecular pathways that regulate epithelial proliferation and differentiation, innovations in epithelial barrier restoration, and applications of bioengineered materials to emulate or repair gut function. By bringing together these advancements, we aim to foster dialogue and collaboration to address unmet clinical needs and accelerate innovation in gut health research.
We look forward to your valuable contributions.
Dr. Natalia Soshnikova
Prof. Dr. Christoph Reinhardt
Guest Editors
Manuscript Submission Information
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Keywords
- intestinal epithelium
- regenerative medicine
- stem cells
- gut microbiota
- epithelial barrier
- bioengineering
- morphogenetic signaling
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