Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience

Dear Colleagues,

Preface: Most of the papers in this Special Issue are closely related to the International Symposium held on December 16th, 2024, at Florida Atlantic University, Boca Raton, Florida, USA. This symposium was entitled “International Symposium on Brain Function/Dysfunction and Intervention” and was held in honor of the outstanding contributions to neuroscience of Dr. Jang-Yen Wu over his long and distinguished career.

Major neurological disorders, including stroke, neurodegenerative diseases, and neuropsychiatric disorders, are characterized by processes involving the over-excitation of neurons as well as the dysregulation of ion channels, vascular and immune systems, and oxidative stress. This Special Issue provides analyses of the pathological processes associated with several of these diseases, such as Alzheimer's disease, stroke, and key developmental disorders, with a focus on (1) cell stress and cell death processes including mitochondrial stress, apoptosis, autophagy, and ER stress, (2) pro-survival mechanisms such as neuroprotective pathways and stem cell mobilization and multicellular communication, and (3) potential therapeutic interventions based on the mechanism associated with these diseases such as gene therapy, enhanced growth factor action, neurotrophic regulation, immunomodulatory approaches and therapeutics to inhibit neuronal excitotoxicity and cell death programs. In addition, new delivery methods that could circumvent the blood–brain barrier are also included as part of the solution for therapeutic intervention of brain diseases. The topic of multicellular communication (neurons, astrocytes, microglia, and vascular cells) to be addressed in this issue is also critical in providing insights into therapeutic processes as well as advancing knowledge in neuronal protection and neurogenesis in general.

For this Special Issue, we welcome the submission of original articles and reviews in the neuroscience field, highlighting cell survival, neurotrophic action, cell–cell communication, neuro-regeneration processes, and immunomodulatory targeting.

Prof. Dr. Howard Prentice
Prof. Dr. Jang-Yen Wu
Guest Editors

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