New Insights into Inflammasome: Mechanisms of Activation, Cell Death, and Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 81
Special Issue Editor
Special Issue Information
Dear Colleagues,
Since the discovery of the first inflammasome in the early 2000s, our understanding of inflammasomes has profoundly advanced. These multiprotein complexes play a critical role in the innate immune response by detecting pathogenic microorganisms and endogenous stress signals. Upon activation, the inflammasomes initiate a cascade of events leading to the production of pro-inflammatory cytokines and a form of programmed cell death known as pyroptosis. This process is crucial for the elimination of infections and damaged cells and the restoration of homeostasis. However, dysregulated inflammasome activity has been strongly linked to numerous chronic inflammatory diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. Moreover, gain-of-function mutations in the inflammasome sensors are responsible for various autoinflammatory syndromes. A deeper understanding of the activation and cell death mechanisms they trigger opens new avenues for therapeutic interventions to modulate inflammasome components to treat these diseases.
Therefore, in this Special Issue, we invite you to submit your articles to contribute to the latest advancements in inflammasome research, offering valuable insights for scientists and clinicians. Manuscripts providing translational value will be particularly welcome.
Dr. Ana Tapia-Abellán
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inflammasomes
- inflammation
- pyroptosis
- chronic diseases
- autoinflammatory syndromes
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