Mitochondrial Dysfunction in Neurodegeneration: A Translational Perspective
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 25 August 2025 | Viewed by 2291
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria after traumatic brain injury (TBI) have emerged as a focal point in translational research, with their pivotal role in the pathophysiology of TBI being demonstrated. These cellular powerhouses play a multifaceted role in energy production, calcium homeostasis, and cell survival, making them susceptible to dysfunction following TBI.
Studies have revealed that TBI triggers a cascade of events leading to mitochondrial dysfunction. The disruption of mitochondrial membrane potential, impaired oxidative phosphorylation, and excessive reactive oxygen species (ROS) production contribute to energy depletion and oxidative stress, exacerbating neuronal damage. Mitochondrial DNA damage and altered mitochondrial dynamics further exacerbate the dysfunction, leading to a vicious cycle of neuronal death and inflammation.
Furthermore, understanding the intricate interplay between mitochondrial dysfunction and other secondary injury mechanisms, such as neuroinflammation and excitotoxicity, is crucial for developing comprehensive therapeutic strategies. Mitochondria serve as a convergence point for various pathways involved in TBI pathology, making them an attractive target for translational research.
This Special Issue aims to address the current trend in translational research, focusing on mitochondrial dysfunction after TBI by unraveling the underlying mechanisms and exploring potential therapeutic interventions as well as addressing technological advancements in the field, with the hope of ultimately improving outcomes and advancing clinical management in TBI patients.
Dr. Hemendra Vekaria
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrial dysfunction
- traumatic brain injury
- secondary damage
- bioenergetics
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
