The Epigenetic Landscape of Aging: Mechanisms and Impacts During Cellular and Organismal Longevity
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 386
Special Issue Editors
Interests: bone biology; osteoporosis; osteoarthritis; hematopoiesis; neutrophil; bioengineering; tissue engineering; crosstalk; cell death; liver biology; sports medicine; orthopedics
Special Issue Information
Dear Colleagues,
The aging process is influenced by a complex network of epigenetic modifications that regulate gene expression without altering the underlying DNA sequence. These epigenetic changes, including DNA methylation, histone modifications, and non-coding RNA activity, are essential in determining cellular function during aging. As the organism ages, epigenetic dysregulation contributes to the decline in cellular homeostasis and tissue function, ultimately leading to age-related diseases like malignancies, cardiovascular diseases, and degenerative diseases in organs like the brain and bone. Understanding the mechanisms driving these epigenetic alterations is crucial for developing interventions that may promote healthy aging.
This Special Issue will explore topics such as age-related changes in epigenetic patterns, the role of epigenetics in cellular senescence, the impact of environmental factors on epigenetic aging, and potential therapeutic strategies targeting the epigenome. Contributions addressing both in vitro models and in vivo studies, along with bioinformatics approaches to aging epigenetics, are encouraged to provide a comprehensive understanding of the epigenetic landscape of aging.
Dr. Siyu Shen
Dr. Dazhuan Xin
Guest Editors
Manuscript Submission Information
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Keywords
- epigenetic regulation
- cellular senescence
- aging
- DNA methylation
- histone modification
- non-coding RNA
- cancer epigenetics
- neurodegenerative diseases
- musculoskeletal degenerative disorders
- cardiovascular diseases
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