Regulation of Cell Division

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1179

Special Issue Editor


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Guest Editor
Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO 65409, USA
Interests: actomyosin ring; cytokinesis; septation; mitotic exit network

Special Issue Information

Dear Colleagues,

Cell division requires the coordination of chromosome segregation and cytokinesis. Since the discovery of cyclin-dependent kinase (CDK) in yeasts, research on many types of cells has led to insights on how mitosis, cytokinesis, and abscission are regulated. How cells trigger the assembly of the mitotic spindle, prevent anaphase and achieve the correct attachment of chromosomes to microtubules, prevent premature actomyosin ring contraction, and resolve intracellular bridges are essential questions in cell biology that have implications for human health.

This Special Issue will focus on the regulation of cell division. Topics will include regulatory pathways, mitotic checkpoints, and the regulation of actomyosin ring assembly, contraction, and abscission.

Dr. Katie Shannon
Guest Editor

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Keywords

  • mitosis
  • kinetochore
  • chromosome segregation
  • actomyosin ring
  • cytokinesis
  • septation
  • mitotic exit network
  • spindle assembly checkpoint

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Published Papers (1 paper)

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Research

24 pages, 4202 KiB  
Article
Expression Dynamics and Genetic Compensation of Cell Cycle Paralogues in Saccharomyces cerevisiae
by Gabriele Schreiber, Facundo Rueda, Florian Renner, Asya Fatima Polat, Philipp Lorenz and Edda Klipp
Cells 2025, 14(6), 412; https://doi.org/10.3390/cells14060412 - 11 Mar 2025
Viewed by 823
Abstract
Cell cycle progression of the yeast Saccharomyces cerevisiae is largely driven by the expression of cyclins, which in turn bind the cyclin-dependent kinase CDK1 providing specificity. Due to the duplication of the yeast genome during evolution, most of the cyclins are present as [...] Read more.
Cell cycle progression of the yeast Saccharomyces cerevisiae is largely driven by the expression of cyclins, which in turn bind the cyclin-dependent kinase CDK1 providing specificity. Due to the duplication of the yeast genome during evolution, most of the cyclins are present as a pair of paralogues, which are considered to have similar functions and periods of expression. Here, we use single molecule inexpensive fluorescence in situ hybridization (smiFISH) to measure the expression of five pairs of paralogous genes relevant for cell cycle progression (CLN1/CLN2, CLB5/CLB6, CLB3/CLB4, CLB1/CLB2 and ACE2/SWI5) in a large number of unsynchronized single cells representing all cell cycle phases. We systematically compare their expression patterns and strengths. In addition, we also analyze the effect of the knockout of one part of each pair on the expression of the other gene. In order to classify cells into specific cell cycle phases, we developed a convolutional neural network (CNN). We find that the expression levels of some cell-cycle related paralogues differ in their correlation, with CLN1 and CLN2 showing strong correlation and CLB3 and CLB4 showing weakest correlation. The temporal profiles of some pairs also differ. Upon deletion of their paralogue, CLB1 and CLB2 seem to compensate for the expression of the other gene, while this was not observed for ACE2/SWI5. Interestingly, CLB1 and CLB2 also seem to share work between mother and bud in the G2 phase, where CLB2 is primarily expressed in the bud and CLB1 in the mother. Taken together, our results suggest that paralogues related to yeast cell cycle progression should not be considered as the same but differ both in their expression strength and timing as well in their precise role in cell cycle regulation. Full article
(This article belongs to the Special Issue Regulation of Cell Division)
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