Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Insights into Cancer Immune Responsiveness submission deadline 30 Mar 2026 | Viewed by 157 | Submission Open
Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines
Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain submission deadline 30 Mar 2026 | Viewed by 133 | Submission Open
Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors
(This special issue belongs to the Section Cellular Pathology)
Impact of Chronic Substance Exposure on Hematopoiesis and Immunity
edited by and
submission deadline 30 Mar 2026 | Viewed by 119 | Submission Open
Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells
Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment
edited by
submission deadline 30 Mar 2026 | Viewed by 116 | Submission Open
Keywords: tumor microenvironment; drug delivery; nanoparticle
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 30 Mar 2026 | Viewed by 108 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Molecular Mechanisms and Biomarker Development in Prostate Cancer
edited by Vikas Mehta and Behtash Ghazi Nezami
submission deadline 30 Mar 2026 | Viewed by 83 | Submission Open
Keywords: androgen receptor; prostate molecular alterations; biomarkers
Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders submission deadline 31 Mar 2026 | 5 articles | Viewed by 24744 | Submission Open
Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections
(This special issue belongs to the Section Cellular Immunology)
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2026 | 3 articles | Viewed by 13244 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 7946 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact submission deadline 31 Mar 2026 | 3 articles | Viewed by 6374 | Submission Open
Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems
(This special issue belongs to the Section Cellular Pathology)
Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches
edited by Yuxiang Xie and Jingqi Yan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 3963 | Submission Open
Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies
(This special issue belongs to the Section Cells of the Nervous System)
Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses
edited by Nianli Sang
submission deadline 31 Mar 2026 | 2 articles | Viewed by 3875 | Submission Open
Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis
(This special issue belongs to the Section Cell Signaling)
Advances in Reproductive Biology: Cellular and Molecular Mechanisms
edited by and Clara González-Marín
submission deadline 31 Mar 2026 | 3 articles | Viewed by 3294 | Submission Open
Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations
(This special issue belongs to the Section Reproductive Cells and Development)
Drosophila as a Model for Understanding Human Disease
edited by Zhe Han
submission deadline 31 Mar 2026 | 3 articles | Viewed by 2991 | Submission Open
Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research
(This special issue belongs to the Section Cellular Pathology)
Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease submission deadline 31 Mar 2026 | 1 articles | Viewed by 2357 | Submission Open
Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management
(This special issue belongs to the Section Tissues and Organs)
Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells submission deadline 31 Mar 2026 | 1 articles | Viewed by 2346 | Submission Open
Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine
(This special issue belongs to the Section Stem Cells)
Molecular Insights into Vascular Physiology and Pathology
edited by Suravi Majumder
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1995 | Submission Open
Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies submission deadline 31 Mar 2026 | 1 articles | Viewed by 1495 | Submission Open
Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1465 | Submission Open
Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors
(This special issue belongs to the Section Cells of the Nervous System)
From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
edited by Amy H. Attaway and Saurabh Mishra
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1259 | Submission Open
Keywords: mitochondrial oxidation; ROS; aging; disease
Cellular Mechanisms in Pregnancy and Foetal Development submission deadline 31 Mar 2026 | 1 articles | Viewed by 1242 | Submission Open
Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth
The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1180 | Submission Open
Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering
The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival
edited by and Giulio Menegazzi
submission deadline 31 Mar 2026 | 1 articles | Viewed by 738 | Submission Open
Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Insights into Allergies and Allergic Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 310 | Submission Open
Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms
(This special issue belongs to the Section Cellular Immunology)
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 299 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections
edited by
submission deadline 31 Mar 2026 | Viewed by 271 | Submission Open
Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication
Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration
edited by Mukund Srinivasan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 232 | Submission Open
Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress
Current Research on Immunotherapy for Glioblastoma
edited by Markella Zannikou
submission deadline 31 Mar 2026 | Viewed by 224 | Submission Open
Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy
(This special issue belongs to the Section Cellular Immunology)
Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease
edited by Praveen Koganti and
submission deadline 31 Mar 2026 | Viewed by 223 | Submission Open
Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway
Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics
edited by
submission deadline 31 Mar 2026 | Viewed by 211 | Submission Open
Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis
Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 190 | Submission Open
Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies
Multi-Omics Technologies in Immunity Within Tumors submission deadline 31 Mar 2026 | Viewed by 190 | Submission Open
Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity
Neurodegenerative Diseases and Related Proteins
edited by Tian Liu
submission deadline 31 Mar 2026 | Viewed by 190 | Submission Open
Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 31 Mar 2026 | Viewed by 186 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
(This special issue belongs to the Section Cell Microenvironment)
Therapeutic Targeting of MicroRNAs in Human Cancer
edited by
submission deadline 31 Mar 2026 | Viewed by 180 | Submission Open
Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies
(This special issue belongs to the Section Cell and Gene Therapy)
Advances in CAR Cell Therapies and Manufacturing
edited by William J. Kelly and Madhuresh C. Sumit
submission deadline 31 Mar 2026 | Viewed by 176 | Submission Open
Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines
Molecular and Cellular Drivers of Parkinson's Disease
edited by and
submission deadline 31 Mar 2026 | Viewed by 169 | Submission Open
Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death
(This special issue belongs to the Section Cells of the Nervous System)
Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine
edited by and Andrea Wittig
submission deadline 31 Mar 2026 | Viewed by 169 | Submission Open
Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition submission deadline 31 Mar 2026 | Viewed by 168 | Submission Open
Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics
GABAA Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms
edited by Tingwei Mu and Yajuan Wang
submission deadline 31 Mar 2026 | Viewed by 162 | Submission Open
Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms
Hepatoblastoma: Molecular Mechanisms and Therapeutic Strategies submission deadline 31 Mar 2026 | Viewed by 161 | Submission Open
Keywords: hepatoblastoma; APC; ARID1; β -catenin; hepatocellular carcinoma; hippo; YAP; pathogenesis; therapeutic strategies; molecular mechanisms
Cellular and Molecular Insights into Gynecologic Tumors
edited by and
submission deadline 31 Mar 2026 | Viewed by 160 | Submission Open
Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies
Stem Cells and Endometrium
edited by Shiying Jin
submission deadline 31 Mar 2026 | Viewed by 149 | Submission Open
Keywords: stem cell; homeostasis; regeneration; endometrium
(This special issue belongs to the Section Stem Cells)
Next-Generation CAR-T Cell Therapy: From Bench to Bedside
edited by and
submission deadline 31 Mar 2026 | Viewed by 126 | Submission Open
Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models
(This special issue belongs to the Section Cellular Immunology)
Cell Death and Apoptosis
edited by and
submission deadline 31 Mar 2026 | Viewed by 122 | Submission Open
Keywords: apoptosis; necroptosis; pyroptosis; ferroptosis; regulated cell death; signaling pathways; tumor biology; resistance mechanisms
(This special issue belongs to the Section Cellular Pathology)
From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria
edited by Sonam Gurung
submission deadline 31 Mar 2026 | Viewed by 117 | Submission Open
Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)
Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies
edited by and Daniela Yildiz
submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open
Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing
Regulation of Ca2+ Signals in Human Disease
edited by Yandong Zhou
submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open
Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets
(This special issue belongs to the Section Cell Signaling)
Cellular and Molecular Mechanisms in Aging
edited by Michel Satya Naslavsky and Mateus Vidigal
submission deadline 1 Apr 2026 | 1 articles | Viewed by 1574 | Submission Open
Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly
(This special issue belongs to the Section Cellular Aging)
Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications
edited by , Shibo Wei and
submission deadline 1 Apr 2026 | Viewed by 130 | Submission Open
Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism
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