Cellular and Molecular Mechanisms in Aging

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: 1 April 2026 | Viewed by 1148

Special Issue Editors


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Guest Editor
Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Interests: genetic medicine; biomedicine

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Guest Editor
Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo—USP, São Paulo, Brazil
Interests: genetic medicine; biomedicine

Special Issue Information

Dear Colleagues,

Aging is a multifaceted biological process influenced by a complex interplay of genetic, environmental, and lifestyle factors. Over the past decades, advancements in cellular and molecular biology have significantly deepened our understanding of aging mechanisms and age-related diseases. Cellular models, such as primary cells, immortalized cell lines, and induced pluripotent stem cells (iPSCs), have become indispensable tools for elucidating the molecular pathways that drive the decline in cellular function, tissue integrity, and organ performance over time.

In this Special Issue of Cells, titled “Cellular and Molecular Mechanisms in Aging”, we aim to gather cutting-edge research that leverages cellular models to uncover novel insights into aging biology. We welcome original research articles, comprehensive reviews, and short perspectives that address the challenges and innovations in the field.

Topics of interest include, but are not limited to, the following:

  • Cellular senescence and aging;
  • Genomic stability and DNA repair mechanisms;
  • Oxidative stress and mitochondrial dysfunction;
  • Cellular models of neurodegeneration and cardiovascular aging;
  • In vitro models for lifespan and healthspan studies.

Dr. Michel Satya Naslavsky
Dr. Mateus Vidigal
Guest Editors

Manuscript Submission Information

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Keywords

  • cellular senescence
  • aging models
  • DNA repair
  • neurodegeneration
  • elderly

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Published Papers (1 paper)

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Review

16 pages, 627 KB  
Review
Essential Pieces of the Puzzle: The Roles of VEGF and Dopamine in Aging
by Melanie B. Thompson, Sanjay P. Tirupattur, Nandini Vishwakarma and Laxmansa C. Katwa
Cells 2025, 14(15), 1178; https://doi.org/10.3390/cells14151178 - 31 Jul 2025
Cited by 1 | Viewed by 738
Abstract
Aging is a well-known, complex physiological process characterized by progressive functional decline and increased susceptibility to disease, particularly in the cardiovascular and nervous systems. While genetic and environmental factors can shape its advancement, molecular regulators such as vascular endothelial growth factor (VEGF) and [...] Read more.
Aging is a well-known, complex physiological process characterized by progressive functional decline and increased susceptibility to disease, particularly in the cardiovascular and nervous systems. While genetic and environmental factors can shape its advancement, molecular regulators such as vascular endothelial growth factor (VEGF) and dopamine signaling have emerged as critical factors in maintaining vascular and neural health. VEGF promotes angiogenesis and tissue repair, while dopamine, primarily recognized for its neuromodulatory roles, regulates vascular tone and appears to modulate VEGF activity. Despite substantial research on their roles in cardiovascular and neurodegenerative diseases, little is known about how VEGF and dopamine interact in the aging process, particularly in healthy versus unhealthy aging contexts. This review describes existing evidence on the independent and potentially complementary roles of VEGF and dopamine in aging, emphasizing their influence on maintaining or improving neurovascular health. It also explores how lifestyle interventions may be beneficial in modulating VEGF and dopamine signaling pathways in the aging population. By addressing the current knowledge gap surrounding VEGF–dopamine crosstalk, this review highlights the need for further investigation into their combined effects and targeting molecular interaction to unlock new research avenues for innovative strategies for healthy aging and the potential treatment of age-related diseases. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms in Aging)
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