The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 68

Special Issue Editors


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Guest Editor
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, Italy
Interests: tumor microenvironment; melanoma progression; cancer stem cells; tumor acidosis; tumor metabolism
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Guest Editor
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, Italy
Interests: tumor microenvironment; cancer stem cells; hypoxia; cancer metabolism; stem cell niche

Special Issue Information

Dear Colleagues,

The tumor microenvironment (TME) is a complex and continuously evolving entity that is the product of developing crosstalk between different cell types. It comprises a heterogeneous collection of infiltrating and resident host cells, including stromal and immune cells, secreted factors, extracellular vesicles, blood vessels and extracellular matrix. The dynamic and reciprocal relationship between cancer cells and components of the TME supports several properties of tumor cells, including cell survival, local invasion, metastatic dissemination and drug resistance. Recent data have demonstrated that the intrinsic physical and chemical alterations characterizing the TME, such as hypoxia or acidosis, together with the different cell types residing within it, contribute to the metabolic reprogramming of tumor cells, which enables cellular adaptation to nutritional fluctuation and supports tumor cell survival under nutrient-scarce conditions, limited oxygen supply, immune attack, and clinical treatments.

In this Special Issue, we encourage the submission of relevant articles and reviews on the interplay between tumor microenvironment, including all its properties and components, tumor metabolism, and cell survival regulation, considering new therapeutic strategies to overcome the resistance to therapies.

Dr. Silvia Peppicelli
Dr. Giulio Menegazzi
Guest Editors

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Keywords

  • tumor microenvironment
  • metabolic cross-talk
  • metabolic reprogramming
  • extracellular vesicles
  • cell survival
  • therapy resistance

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Published Papers

This special issue is now open for submission.
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