Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 1964
Special Issue Editors
Interests: human mesenchymal stem cells; cell senescence; cell biology; cell differentiation
Special Issues, Collections and Topics in MDPI journals
Interests: human mesenchymal stem cells; cell senescence; cell biology; cell differentiation; use of chemical (natural or synthetic molecules) od physical stimuli to modulate the stemness, the proliferation, differentiation and senescence of human stem cells from adult and perinatal tissues; the relationship between cytoskeleton alteration and morpho-functional properties of human stem cells from adult and perinatal tissues; strategies to induce cardiomyocytes to re-enter the cell cycle; gender differences in transcriptome and cell senescence in human stem cells; theoretic biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mesenchymal stem/stromal cells (MSCs) are adult stem cells used in regenerative medicine to treat various pathologies due to their self-renewal ability and multilineage differentiation. However, MSCs undergo cellular senescence during their in vitro expansion, and they may become senescent in vivo due to the influence of multiple molecular, cellular, and environmental interactions. Many studies have been carried out to investigate the biological properties of MSCs and the possibility of modulating their behaviour pre- and post-transplantation. Only a few have successfully managed to reach clinical availability, implying that we probably do not yet have a full understanding of the biology of MSCs.
For this Special Issue, we invite authors/experts to submit high-quality original research articles that further expand our knowledge of and provide us with insights into MSCs. We are particularly interested in studies deepening our understanding of senescence and differentiation in tissue-specific MSCs, as well as those exploring the modulation of these processes through natural and synthetic molecules with the aim of improving MSC potential in tissue engineering and regenerative medicine.
Dr. Federica Facchin
Dr. Silvia Canaider
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tissue-specific mesenchymal stem cells
- cell senescence
- cell differentiation
- natural and synthetic molecules
- tissue engineering
- regenerative medicine
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