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Cells
Special Issues
Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches
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Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2540

Special Issue Editors

Dr. Yuxiang Xie

E-Mail Website
Guest Editor
Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-209, 35 Convent Drive, Bethesda, MD 20892-3706, USA
Interests: neurodegenerative mechanisms; autophagy; mitochondria; axonal transport
Dr. Jingqi Yan

E-Mail Website
Co-Guest Editor
Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH, USA
Interests: cell-cell communications; autophagy; exosomes; autism spectrum disorders (ASDs); neural circuits

Special Issue Information

Dear Colleagues,

Axonal transport is a critical cellular process responsible for the movement of organelles, proteins, and other molecules along the axons of neurons. This process is essential for maintaining neuronal function and survival. Disruptions in axonal transport are implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and peripheral neuropathies. This Special Issue aims to bring together cutting-edge research on the molecular mechanisms of axonal transport, its role in neurodegenerative diseases, and potential therapeutic strategies to ameliorate transport-related dysfunctions.

This Special Issue will cover a broad range of topics related to axonal transport, including, but not limited to, the following:

  • Molecular mechanisms of anterograde and retrograde transport;
  • Role of motor proteins in axonal transport;
  • Regulation of axonal transport by signaling pathways;
  • Cargo selection, sorting, and delivery mechanisms;
  • Impact of axonal transport dysfunction on neurodegenerative diseases;
  • Axonal transport in development and aging;
  • Therapeutic approaches to targeting axonal transport defects;
  • New technological achievements in studying axonal transport;
  • Animal models and clinical studies of axonal transport disorders.

Dr. Yuxiang Xie
Dr. Jingqi Yan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • axonal transport
  • motor proteins
  • autophagy–lysosome pathway
  • neurodegenerative diseases
  • therapeutic strategies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

20 pages, 1662 KiB  
Review
Exploring the Role of Axons in ALS from Multiple Perspectives
by Xiaosu Chen, Shuchang Lv, Jinmeng Liu, Yingjun Guan, Chunjie Xu, Xiaonan Ma, Mu Li, Xue Bai, Kexin Liu, Haoyun Zhang, Qiupeng Yan, Fenghua Zhou and Yanchun Chen
Cells 2024, 13(24), 2076; https://doi.org/10.3390/cells13242076 - 17 Dec 2024
Viewed by 2220
Abstract
Amyotrophic lateral sclerosis (ALS), commonly known as motor neuron disease, is a neurodegenerative disorder characterized by the progressive degeneration of both upper and lower motor neurons. This pathological process results in muscle weakness and can culminate in paralysis. To date, the precise etiology [...] Read more.
Amyotrophic lateral sclerosis (ALS), commonly known as motor neuron disease, is a neurodegenerative disorder characterized by the progressive degeneration of both upper and lower motor neurons. This pathological process results in muscle weakness and can culminate in paralysis. To date, the precise etiology of ALS remains unclear. However, a burgeoning body of research indicates that axonal dysfunction is a pivotal element in the pathogenesis of ALS and significantly influences the progression of disease. Dysfunction of axons in ALS can result in impediments to nerve impulse transmission, leading to motor impairment, muscle atrophy, and other associated complications that severely compromise patients’ quality of life and survival prognosis. In this review, we concentrate on several key areas: the ultrastructure of axons, the mechanisms of axonal degeneration in ALS, the impact of impaired axonal transport on disease progression in ALS, and the potential for axonal regeneration within the central nervous system (CNS). Our objective is to achieve a more holistic and profound understanding of the multifaceted role that axons play in ALS, thereby offering a more intricate and refined perspective on targeted axonal therapeutic interventions. Full article
(This article belongs to the Special Issue Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches)
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