Cell Death and Apoptosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 9
Special Issue Editors
Interests: apoptosis; endoplasmic reticulum stress; signal transduction; cancer biology; glioblastoma multiforme; temozolomide resistance mechanisms
Special Issue Information
Dear Colleagues,
Cell death is a fundamental biological process that ensures tissue homeostasis, guides embryonic development, and regulates immune responses. Traditionally, it was divided into non-regulated forms, such as necrosis, and genetically regulated mechanisms, including apoptosis. Over the past decades, this view has greatly expanded with the recognition of additional regulated pathways—such as necroptosis, pyroptosis, and ferroptosis—that reveal the remarkable complexity and diversity of how cells can die.
The regulation of cell death is tightly connected to human health and disease. While non-regulated cell death often results from injury or toxic insults, dysregulation of cell death mechanisms is implicated in many pathological conditions. Among them, cancer is particularly prominent, as resistance to apoptosis and other cell death pathways represents a key hallmark of tumor biology and influences therapeutic response. Beyond oncology, aberrant cell death regulation contributes to neurodegeneration, infection, and autoimmune disorders.
This Special Issue of Cells aims to gather original research and review articles that advance our understanding of apoptosis and alternative modes of cell death, from their molecular machinery and signaling pathways to their impact on health and disease. We hope to provide a broad and stimulating forum that reflects the dynamic evolution of this fascinating field.
Dr. Marianna Pap
Dr. Judit Varga
Guest Editors
Manuscript Submission Information
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Keywords
- apoptosis
- necroptosis
- pyroptosis
- ferroptosis
- regulated cell death
- signaling pathways
- tumor biology
- resistance mechanisms
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