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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Platelet Physiology and Dysfunction

edited by Serena Valsami and

Sotiris Fortis

submission deadline 10 Nov 2026 | Viewed by 216 | Submission Open

Keywords: platelets; platelet function; platelet physiology; platelet dysfunction; platelet disorders; platelet biology; pathophysiology; platelet transfusion; hereditary platelet disorders; acquired platelet disorders

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

edited by Qingdong Guan

submission deadline 15 Nov 2026 | 5 articles | Viewed by 18822 | Submission Open

Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells

(This special issue belongs to the Section Cellular Immunology)

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Nov 2026 | 7 articles | Viewed by 10747 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Nov 2026 | 4 articles | Viewed by 6326 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Nov 2026 | 1 articles | Viewed by 2655 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 15 Nov 2026 | 1 articles | Viewed by 1316 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Cancer and Vessels: Insights at the Cellular and Molecular Levels

edited by Francesco Pezzella and Tom Donnem

submission deadline 15 Nov 2026 | 1 articles | Viewed by 1058 | Submission Open

Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms and Molecular Signaling in Heart Failure

edited by Przemyslaw Leszek

submission deadline 15 Nov 2026 | 1 articles | Viewed by 906 | Submission Open

Keywords: heart failure; cellular mechanisms and molecular signaling; new directions in cellular mechanisms promising for novel heart failure therapies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Metabolic Regulation of Cell Behavior and Implications for Aging

edited by

Eloy Bejarano

and José Antonio Rodríguez Navarro

submission deadline 15 Nov 2026 | Viewed by 474 | Submission Open

Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Nov 2026 | Viewed by 423 | Submission Open

Keywords: traumatic brain injury; stroke; blood–brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)

edited by

Yong-Xiao Wang

submission deadline 15 Nov 2026 | Viewed by 257 | Submission Open

Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling

Post-Transcriptional Control of Stem Cell Fate and Neural Development

edited by

Kun Tan

submission deadline 16 Nov 2026 | 1 articles | Viewed by 2033 | Submission Open

Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology

(This special issue belongs to the Section Stem Cells)

Placenta in Tissue Engineering and Regeneration

edited by

Gayathri Rajaraman

submission deadline 16 Nov 2026 | Viewed by 590 | Submission Open

Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration

Kidney Development: Cellular and Molecular Insights

edited by

Renfang Song Taylor

submission deadline 18 Nov 2026 | 1 articles | Viewed by 1879 | Submission Open

Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2015 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene–environment interactions; developing therapies

Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression

edited by

Katerina Gioti

and

Apostolos Beloukas

submission deadline 20 Nov 2026 | 1 articles | Viewed by 862 | Submission Open

Keywords: cancer progression; cell death; senescence; cancer therapy

Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders

edited by

Shaohua Qi

and

George Augustine

submission deadline 20 Nov 2026 | Viewed by 561 | Submission Open

Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms of Microglia/Macrophages in the Nervous System

edited by Emanuela Paldino

submission deadline 20 Nov 2026 | Viewed by 433 | Submission Open

Keywords: microglia; macrophages; neurological disorders

Cellular and Molecular Basis of Sjögren’s Syndrome

edited by Muhammad Shahnawaz Soyfoo

submission deadline 20 Nov 2026 | Viewed by 408 | Submission Open

Keywords: Sjögren disease; epithelial dysfunction; immune tolerance; autoimmunity

Spotlight on Cell Biology Science: Selected Contributions from Editorial Board Members and Invited Experts

edited by

Alexander E. Kalyuzhny

submission deadline 20 Nov 2026 | Viewed by 202 | Submission Open

Keywords: cell structure; cell physiology; cellular metabolism; cellular immunology; intra- and extracellular signaling; cell movement and motility; autophagy; apoptosis; cell aging; cell senescence; cell techniques; cell growth and differentiation; stem cells; genetic disorders and therapy; omics; plant, algae and fungi cell biology; neurodegeneration; neuroinflammation

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Nov 2026 | 9 articles | Viewed by 26200 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants

edited by Aziz Khan and

Xin Zhang

submission deadline 25 Nov 2026 | 3 articles | Viewed by 16034 | Submission Open

Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 25 Nov 2026 | 2 articles | Viewed by 11860 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Nov 2026 | 1 articles | Viewed by 4009 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by

Isabel Martinez-Pena y Valenzuela

submission deadline 25 Nov 2026 | Viewed by 540 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Genetic Mechanisms and Pathological Links in Neurodevelopmental Disorders

edited by Luigi Balasco and

Cinzia Severini

submission deadline 25 Nov 2026 | Viewed by 272 | Submission Open

Keywords: neurodevelopmental disorders; genetics; pathogenic mechanisms; genetic animal models; gene–environment interactions; rare variants; common variants; developmental neurobiology; molecular mechanisms; genotype–phenotype relationships

(This special issue belongs to the Section Cellular Neuroscience)

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 30 Nov 2026 | 5 articles | Viewed by 15810 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease

edited by

Ki Ho Park

submission deadline 30 Nov 2026 | 8 articles | Viewed by 12765 | Submission Open

Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2026 | 4 articles | Viewed by 8115 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor–stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Nov 2026 | 6 articles | Viewed by 4964 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4188 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein–protein interactions; post-translational modifications; pharmacological interventions

Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations

edited by

Moncef M. Zouali

submission deadline 30 Nov 2026 | 4 articles | Viewed by 3598 | Submission Open

Keywords: autoimmune diseases; immune cells; lymphocytes; antigen-presenting cells; natural killer cells; innate lymphoid cells; epigenetic modifications; autoimmunity

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3594 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury

edited by

Daniel J. Hellenbrand

and Angela R. Filous

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3196 | Submission Open

Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia

Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms

edited by

Girish Chandra Melkani

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2988 | Submission Open

Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2940 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics

edited by

Roshanak Rahimian

and

Mitra Esfandiarei

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2745 | Submission Open

Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets

B Cells in Action: Interaction Dynamics and Functional Decisions

edited by Michael L. Atchison and

Sulagna Sanyal

submission deadline 30 Nov 2026 | 3 articles | Viewed by 2652 | Submission Open

Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response

(This special issue belongs to the Section Cellular Immunology)

Extracellular Vesicles in Disease Pathogenesis, Therapeutics and Biomarker Discovery

edited by

Susmita Sil

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2640 | Submission Open

Keywords: extracellular vesicles; exosomes; exomeres; apoptotic bodies; macrovesicles; EV-cargoes; EVs as biomarkers; EVs in therapy

(This special issue belongs to the Section Intracellular and Plasma Membranes)

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2156 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2123 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis

edited by Xu Jing

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2119 | Submission Open

Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers

(This special issue belongs to the Section Cellular Metabolism)

Molecular and Cellular Mechanisms of Insulin Secretion

edited by

Haiqiang Dou

submission deadline 30 Nov 2026 | Viewed by 2018 | Submission Open

Keywords: insulin secretion; beta-cells; pancreatic islets; diabetes; exocytosis; Ca2+

(This special issue belongs to the Section Cellular Metabolism)

Glycosylation and Glycoproteins in Human Disease

edited by

Mana Mukherjee

and

Bingmei Fu

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2004 | Submission Open

Keywords: glycobiology; glycosylation; glycoproteins; glycolipids; glycan biomarkers; congenital disorders of glycosylation (cdg); immune modulation; glycan profiling; glycoengineering; host–pathogen interactions; therapeutic glycoproteins; bioorthogonal chemistry

Pulmonary Hypertension: From the Molecular Mechanisms to Novel Therapies

edited by Mohamed Ahmed

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1946 | Submission Open

Keywords: molecular pathways; multi-omics in PH; new therapeutic targets; innovative therapy

(This special issue belongs to the Section Cellular Pathology)

How Does Gene Regulation Affect Cancer Development?

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1716 | Submission Open

Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs

(This special issue belongs to the Section Cell Microenvironment)

Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine

edited by Emanuela Mari

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1684 | Submission Open

Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome

(This special issue belongs to the Section Stem Cells)

Genome Editing in Biomedicine

edited by

Fu-Lei Tang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1530 | Submission Open

Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)

(This special issue belongs to the Section Cell and Gene Therapy)

Cell Cycle Dysregulation in Cancer: From Basic Mechanisms to Therapeutic Targeting

edited by Toshiyuki Sakamaki

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1512 | Submission Open

Keywords: cell cycle; cancer; cyclin-dependent kinases; checkpoint control; targeted therapy; therapeutic resistance; precision oncology; biomarker

(This special issue belongs to the Section Cell Proliferation and Division)

Interaction Between DNA Damage Response and Anti-Cancer Immunity

edited by

Takahiko Murayama

and Jun Nakayama

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1306 | Submission Open

Keywords: DNA damage response; tumor microenvironment; DDR inhibitors; immune checkpoint blockade

(This special issue belongs to the Section Cell and Gene Therapy)

Displaying special issue 301-350 on page 7 of 12.

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