Cell Cycle Dysregulation in Cancer: From Basic Mechanisms to Therapeutic Targeting
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 1432
Editor
Special Issue Information
Dear Colleagues,
The dysregulation of cell cycles is a fundamental hallmark of cancer, driving uncontrolled cell proliferation and tumorigenesis. The precise coordination of cyclins, cyclin-dependent kinases (CDKs), and cell cycle checkpoints is frequently disrupted in malignant cells, contributing to genomic instability, disease progression, and therapeutic resistance. Therefore, a deeper understanding of the molecular mechanisms underlying cell cycle dysregulation is essential in advancing cancer biology and improving treatment strategies. This includes the use of appropriate experimental and translational models that recapitulate the complexity of cell cycle control in vivo.
This Special Issue will cover recent advances in the molecular pathogenesis of cell cycle dysregulation in cancer, oncogenic signaling pathways affecting cell cycle control, DNA damage response and genomic instability, therapeutic targeting of cyclins, CDKs, and checkpoint regulators, mechanisms of resistance to cell cycle-targeted therapies, and the integration of these approaches into precision oncology.
Prof. Dr. Toshiyuki Sakamaki
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell cycle
- cancer
- cyclin-dependent kinases
- checkpoint control
- targeted therapy
- therapeutic resistance
- precision oncology
- biomarker
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
